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A bat MERS-like coronavirus circulates in pangolins and utilizes human DPP4 and host proteases for cell entry.
Chen J, Yang X, Si H, Gong Q, Que T, Li J, Li Y, Wu C, Zhang W, Chen Y, Luo Y, Zhu Y, Li B, Luo D, Hu B, Lin H, Jiang R, Jiang T, Li Q, Liu M, Xie S, Su J, Zheng X, Li A, Yao Y, Yang Y, Chen P, Wu A, He M, Lin X, Tong Y, Hu Y, Shi ZL, Zhou P. Chen J, et al. Cell. 2023 Feb 16;186(4):850-863.e16. doi: 10.1016/j.cell.2023.01.019. Cell. 2023. PMID: 36803605 Free PMC article.
This virus utilizes human dipeptidyl peptidase-4 (hDPP4) as a receptor and host proteases for cell infection, which is enhanced by a furin cleavage site that is absent in all known bat HKU4r-CoVs. The MjHKU4r-CoV-1 spike shows higher binding affinity for hDPP4, and MjHKU4r …
This virus utilizes human dipeptidyl peptidase-4 (hDPP4) as a receptor and host proteases for cell infection, which is enhanced by a furi …
Furin promotes dendritic morphogenesis and learning and memory in transgenic mice.
Zhu B, Zhao L, Luo D, Xu D, Tan T, Dong Z, Tang Y, Min Z, Deng X, Sun F, Yan Z, Chen G. Zhu B, et al. Cell Mol Life Sci. 2018 Jul;75(13):2473-2488. doi: 10.1007/s00018-017-2742-3. Epub 2018 Jan 4. Cell Mol Life Sci. 2018. PMID: 29302702 Free PMC article.
However, the role of furin in neuronal plasticity and learning and memory remains to be elucidated. Here, we report that in brain-specific furin transgenic (Furin-Tg) mice, the dendritic spine density and proliferation of neural progenitor cells were signific …
However, the role of furin in neuronal plasticity and learning and memory remains to be elucidated. Here, we report that in brain-spe …
Proprotein Convertase Furin Regulates Melanogenesis via the Notch Signaling Pathway.
Luo L, Jia W, Zhang Y, Guo Y, Zhu J, Li C. Luo L, et al. Discov Med. 2023 Apr 1;35(175):144-156. doi: 10.24976/Discov.Med.202335175.15. Discov Med. 2023. PMID: 37105924
The present study aimed to investigate furin potential function and mechanisms in melanogenesis. METHODS: Short hairpin RNAs targeting furin gene (sh-furin RNAs) were used to inhibit furin gene expression in human melanoma cell line MNT-1 cells. ...Aft …
The present study aimed to investigate furin potential function and mechanisms in melanogenesis. METHODS: Short hairpin RNAs targetin …
Virus-, host-, immune-based targets for COVID-19 therapy.
Liu W, Zhu HL, Duan Y. Liu W, et al. Drug Discov Today. 2020 Dec;25(12):2071-2073. doi: 10.1016/j.drudis.2020.10.001. Epub 2020 Oct 6. Drug Discov Today. 2020. PMID: 33035666 Free PMC article. No abstract available.
Association Between Serum Furin and Fasting Glucose: A Cross-Sectional Study in Chinese Adults.
He Y, Zhu H, Zhang M, Li J, Ma S, Lu Y, Chen L, Zhang M, Peng H. He Y, et al. Front Endocrinol (Lausanne). 2022 Jan 3;12:781890. doi: 10.3389/fendo.2021.781890. eCollection 2021. Front Endocrinol (Lausanne). 2022. PMID: 35046896 Free PMC article.
To facilitate data interpretation, the association between serum furin and prevalent diabetes was also examined. RESULTS: Serum furin was negatively associated with fasting glucose (beta=-0.18, P<0.001 for log-furin). ...Our findings suggest that serum …
To facilitate data interpretation, the association between serum furin and prevalent diabetes was also examined. RESULTS: Serum fu …
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
International Consortium for Blood Pressure Genome-Wide Association Studies; Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, Pihur V, Vollenweider P, O'Reilly PF, Amin N, Bragg-Gresham JL, Teumer A, Glazer NL, Launer L, Zhao JH, Aulchenko Y, Heath S, Sõber S, Parsa A, Luan J, Arora P, Dehghan A, Zhang F, Lucas G, Hicks AA, Jackson AU, Peden JF, Tanaka T, Wild SH, Rudan I, Igl W, Milaneschi Y, Parker AN, Fava C, Chambers JC, Fox ER, Kumari M, Go MJ, van der Harst P, Kao WH, Sjögren M, Vinay DG, Alexander M, Tabara Y, Shaw-Hawkins S, Whincup PH, Liu Y, Shi G, Kuusisto J, Tayo B, Seielstad M, Sim X, Nguyen KD, Lehtimäki T, Matullo G, Wu Y, Gaunt TR, Onland-Moret NC, Cooper MN, Platou CG, Org E, Hardy R, Dahgam S, Palmen J, Vitart V, Braund PS, Kuznetsova T, Uiterwaal CS, Adeyemo A, Palmas W, Campbell H, Ludwig B, Tomaszewski M, Tzoulaki I, Palmer ND; CARDIoGRAM consortium; CKDGen Consortium; KidneyGen Consortium; EchoGen consortium; CHARGE-HF consortium; Aspelund T, Garcia M, Chang YP, O'Connell JR, Steinle NI, Grobbee DE, Arking DE, Kardia SL, Morrison AC, Hernandez D, Najjar S, McArdle WL, Hadley D, Brown MJ, Connell JM, Hi… See abstract for full author list ➔ International Consortium for Blood Pressure Genome-Wide Association Studies, et al. Nature. 2011 Sep 11;478(7367):103-9. doi: 10.1038/nature10405. Nature. 2011. PMID: 21909115 Free PMC article.
This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A …
This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of Europ …
A novel bat coronavirus with a polybasic furin-like cleavage site.
Zhu W, Huang Y, Gong J, Dong L, Yu X, Chen H, Li D, Zhou L, Yang J, Lu S. Zhu W, et al. Virol Sin. 2023 Jun;38(3):344-350. doi: 10.1016/j.virs.2023.04.009. Epub 2023 May 2. Virol Sin. 2023. PMID: 37141989 Free PMC article.
The furin cleavage sites between CD35 and CD36 are identical. In addition, the receptor-binding domain of Bat CoV CD35 showed a highly similar structure to that of SARS-CoV-1 and SARS-CoV-2, especially in one binding loop. In conclusion, this study deepens our understandin …
The furin cleavage sites between CD35 and CD36 are identical. In addition, the receptor-binding domain of Bat CoV CD35 showed a highl …
The Effects of Asprosin on Exercise-Intervention in Metabolic Diseases.
Liu L, Liu Y, Huang M, Zhang M, Zhu C, Chen X, Bennett S, Xu J, Zou J. Liu L, et al. Front Physiol. 2022 Jul 11;13:907358. doi: 10.3389/fphys.2022.907358. eCollection 2022. Front Physiol. 2022. PMID: 35899030 Free PMC article. Review.
Asprosin is derived from the C-terminal region of the FBN1 gene, which encodes profibrillin that undergoes cleavage by furin protein. In response to fasting with low dietary glucose, asprosin is released as a secreted factor from white adipose tissue, and is transported to …
Asprosin is derived from the C-terminal region of the FBN1 gene, which encodes profibrillin that undergoes cleavage by furin protein. …
Limitations of inhibitory activities of polyphenols on furin-mediated substrate processing.
Zhu J, Declercq J, Creemers JW, Chen C, Cui Y, Van de Ven WJ, Vermorken AJ. Zhu J, et al. Curr Med Chem. 2012;19(21):3641-50. doi: 10.2174/092986712801323162. Curr Med Chem. 2012. PMID: 22716122 Review.
This prompted investigations to identify PC inhibiting polyphenols that could affect IGF-1R-mediated tumorigenesis since pro-IGF-1R is bioactivated by PCs like furin. Initial screening of polyphenols for their impact on in vitro cleavage of fluorogenic peptide substrate Py …
This prompted investigations to identify PC inhibiting polyphenols that could affect IGF-1R-mediated tumorigenesis since pro-IGF-1R is bioac …
Generation and characterization of non-competitive furin-inhibiting nanobodies.
Zhu J, Declercq J, Roucourt B, Ghassabeh GH, Meulemans S, Kinne J, David G, Vermorken AJ, Van de Ven WJ, Lindberg I, Muyldermans S, Creemers JW. Zhu J, et al. Biochem J. 2012 Nov 15;448(1):73-82. doi: 10.1042/BJ20120537. Biochem J. 2012. PMID: 22920187 Free PMC article.
Therefore furin inhibition might be a good strategy for therapeutic intervention, and several furin inhibitors have been generated, although none are entirely furin-specific. To reduce potential side effects caused by cross-reactivity with other proteases, dr …
Therefore furin inhibition might be a good strategy for therapeutic intervention, and several furin inhibitors have been gener …
64 results