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Furin-instructed molecular self-assembly actuates endoplasmic reticulum stress-mediated apoptosis for cancer therapy.
Fu C, Zhan J, Huai J, Ma S, Li M, Chen G, Chen M, Cai Y, Ou C. Fu C, et al. Nanoscale. 2020 Jun 11;12(22):12126-12132. doi: 10.1039/d0nr00151a. Nanoscale. 2020. PMID: 32484200
In this study, we designed a small molecule of 1-Nap to execute furin-instructed molecular self-assembly for selectively inhibiting the growth of MDA-MB-468 cells in vitro and in vivo. ...The furin-instructed self-assembly of 1-Nap is associated with both the ER (1- …
In this study, we designed a small molecule of 1-Nap to execute furin-instructed molecular self-assembly for selectively inhibiting t …
Correction: Furin-instructed molecular self-assembly actuates endoplasmic reticulum stress-mediated apoptosis for cancer therapy.
Fu C , Zhan J , Huai J , Ma S , Li M , Chen G , Chen M , Cai Y , Ou C . Fu C , et al. Nanoscale. 2021 Aug 21;13(31):13558. doi: 10.1039/d1nr90152d. Epub 2021 Jul 29. Nanoscale. 2021. PMID: 34477760
Correction for 'Furin-instructed molecular self-assembly actuates endoplasmic reticulum stress-mediated apoptosis for cancer therapy' by Chenxing Fu et al., Nanoscale, 2020, 12, 12126-12132, DOI: ....
Correction for 'Furin-instructed molecular self-assembly actuates endoplasmic reticulum stress-mediated apoptosis for cancer therapy' …
Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes.
Zhang Q, Xing M, Bao Z, Xu L, Bai Y, Chen W, Pan W, Cai F, Wang Q, Guo S, Zhang J, Wang Z, Wu Y, Zhang Y, Li JD, Song W. Zhang Q, et al. Signal Transduct Target Ther. 2024 Mar 1;9(1):51. doi: 10.1038/s41392-024-01768-6. Signal Transduct Target Ther. 2024. PMID: 38424048 Free PMC article.
In this report we showed that CNTNAP2 undergoes sequential cleavages by furin, ADAM10/17-dependent alpha-secretase and presenilin-dependent gamma-secretase. ...
In this report we showed that CNTNAP2 undergoes sequential cleavages by furin, ADAM10/17-dependent alpha-secretase and presenilin-dep …
Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent Manner.
Chen M, Wang MH, Shen XG, Liu H, Zhang YY, Peng JM, Meng F, Wang TY, Bai YZ, Sun MX, Tian ZJ, Yin X, Cai XH, Tang YD. Chen M, et al. J Virol. 2022 Oct 26;96(20):e0131822. doi: 10.1128/jvi.01318-22. Epub 2022 Sep 29. J Virol. 2022. PMID: 36173190 Free PMC article.
We further demonstrate that gB promotes NRP1 degradation in a furin-cleavage-dependent manner. Interestingly, in this study, we generated gB furin cleavage site (FCS)-knockout PRV (deltafurin PRV) and evaluated its pathogenesis; in vivo, we found that deltafurin PRV …
We further demonstrate that gB promotes NRP1 degradation in a furin-cleavage-dependent manner. Interestingly, in this study, we gener …
Characterization of the furin cleavage motif for HIV-1 trimeric envelope glycoprotein by intact LC-MS analysis.
Schneck NA, Ivleva VB, Cai CX, Cooper JW, Lei QP. Schneck NA, et al. Analyst. 2020 Mar 2;145(5):1636-1640. doi: 10.1039/c9an02098e. Analyst. 2020. PMID: 31932825 Free PMC article.
The Env immunogen is a heavily glycosylated protein composed of 3 identical surface gp120 and gp41 subunits that form into a trimer of heterodimers (3 28 N-glycan sites). During Env immunogen production, endogenous furin works to cleave a hexa-arginine motif connecting the …
The Env immunogen is a heavily glycosylated protein composed of 3 identical surface gp120 and gp41 subunits that form into a trimer of heter …
Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro.
Mao B, Le-Trilling VTK, Wang K, Mennerich D, Hu J, Zhao Z, Zheng J, Deng Y, Katschinski B, Xu S, Zhang G, Cai X, Hu Y, Wang J, Lu M, Huang A, Tang N, Trilling M, Lin Y. Mao B, et al. Emerg Microbes Infect. 2022 Dec;11(1):483-497. doi: 10.1080/22221751.2022.2026739. Emerg Microbes Infect. 2022. PMID: 34989664 Free PMC article.
Additionally, obatoclax impaired the SARS-CoV-2 S-mediated membrane fusion by targeting the MCL-1 protein and reducing furin protease activity. In accordance with these overarching mechanisms, obatoclax blocked the virus entry mediated by different S proteins derived from …
Additionally, obatoclax impaired the SARS-CoV-2 S-mediated membrane fusion by targeting the MCL-1 protein and reducing furin protease …
Identification of eight-protein biosignature for diagnosis of tuberculosis.
Yang Q, Chen Q, Zhang M, Cai Y, Yang F, Zhang J, Deng G, Ye T, Deng Q, Li G, Zhang H, Yi Y, Huang RP, Chen X. Yang Q, et al. Thorax. 2020 Jul;75(7):576-583. doi: 10.1136/thoraxjnl-2018-213021. Epub 2020 Mar 22. Thorax. 2020. PMID: 32201389 Free PMC article.
RESULTS: A two-round screening strategy identified eight-protein biomarkers of TB: I-TAC, I-309, MIG, Granulysin, FAP, MEP1B, Furin and LYVE-1. The sensitivity and specificity of the eight-protein biosignature in diagnosing TB were determined for the training (n=276), test …
RESULTS: A two-round screening strategy identified eight-protein biomarkers of TB: I-TAC, I-309, MIG, Granulysin, FAP, MEP1B, Furin a …
Host and viral determinants for efficient SARS-CoV-2 infection of the human lung.
Chu H, Hu B, Huang X, Chai Y, Zhou D, Wang Y, Shuai H, Yang D, Hou Y, Zhang X, Yuen TT, Cai JP, Zhang AJ, Zhou J, Yuan S, To KK, Chan IH, Sit KY, Foo DC, Wong IY, Ng AT, Cheung TT, Law SY, Au WK, Brindley MA, Chen Z, Kok KH, Chan JF, Yuen KY. Chu H, et al. Nat Commun. 2021 Jan 8;12(1):134. doi: 10.1038/s41467-020-20457-w. Nat Commun. 2021. PMID: 33420022 Free PMC article.
While SARS-CoV infection is substantially limited by the sialic acid-mediated restriction in both human lung epithelial cells and ex vivo human lung tissues, infection by SARS-CoV-2 is limited to a lesser extent. We further demonstrate that the furin-like cleavage site in …
While SARS-CoV infection is substantially limited by the sialic acid-mediated restriction in both human lung epithelial cells and ex vivo hu …
Enhanced UV-induced skin carcinogenesis in transgenic mice overexpressing proprotein convertases.
Fu J, Bassi DE, Zhang J, Li T, Cai KQ, Testa CL, Nicolas E, Klein-Szanto AJ. Fu J, et al. Neoplasia. 2013 Feb;15(2):169-79. doi: 10.1593/neo.121846. Neoplasia. 2013. PMID: 23441131 Free PMC article.
Because of the human relevancy of UV radiation in the etiopathogenesis of human skin cancer, we investigated whether or not transgenic mice overexpressing either furin alone or both furin and PACE4 show increased susceptibility to UV carcinogenesis. ...Thus, we obse …
Because of the human relevancy of UV radiation in the etiopathogenesis of human skin cancer, we investigated whether or not transgenic mice …
Rational redesign of inhibitors of furin/kexin processing proteases by electrostatic mutations.
Cai XH, Zhang Q, Ding DF. Cai XH, et al. Acta Pharmacol Sin. 2004 Dec;25(12):1712-818. Acta Pharmacol Sin. 2004. PMID: 15569420 Free article.
AIM: To model the three-dimensional structure and investigate the interaction mechanism of the proprotein convertase furin/kexin and their inhibitors (eglin c mutants). METHODS: The three-dimensional complex structures of furin/kexin with its inhibitors, eglin c mut …
AIM: To model the three-dimensional structure and investigate the interaction mechanism of the proprotein convertase furin/kexin and …
20 results