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Page 1
Adrenal function and dysfunction in critically ill patients.
Téblick A, Peeters B, Langouche L, Van den Berghe G. Téblick A, et al. Nat Rev Endocrinol. 2019 Jul;15(7):417-427. doi: 10.1038/s41574-019-0185-7. Nat Rev Endocrinol. 2019. PMID: 30850749 Review.
Researchers suggested that CIRCI could be diagnosed by a suppressed incremental cortisol response to an injection of adrenocorticotropic hormone, irrespective of the baseline plasma cortisol. This concept triggered several randomized clinical trials on the impact of large …
Researchers suggested that CIRCI could be diagnosed by a suppressed incremental cortisol response to an injection of adrenocorticotro …
Critical illness-related corticosteroid insufficiency during difficult weaning from mechanical ventilation.
Bagate F, Bedet A, Tomberli F, Boissier F, Razazi K, de Prost N, Carteaux G, Mekontso Dessap A. Bagate F, et al. Ann Intensive Care. 2021 Apr 26;11(1):65. doi: 10.1186/s13613-021-00852-2. Ann Intensive Care. 2021. PMID: 33900478 Free PMC article.
CIRCI was defined as T(0) < 10 mug/dL (276 nmol/L) and/or delta(max) < 9 mug/dL (248 nmol/L) and inadequate adrenal reserve as delta(max) < 9 mug/dL. ...We did not find a significant association between CIRCI and WiPO....
CIRCI was defined as T(0) < 10 mug/dL (276 nmol/L) and/or delta(max) < 9 mug/dL (248 nmol/L) and inadequate adrenal rese …
SNARE-ing the Reason for Post-Cardiac Surgery Critical Illness-Related Corticosteroid Insufficiency.
Diehl N, Kibiryeva N, Marshall J, Tsai SL, Farias JS, Silva-Gburek J, Erickson LA. Diehl N, et al. Genes (Basel). 2024 Jan 20;15(1):128. doi: 10.3390/genes15010128. Genes (Basel). 2024. PMID: 38275610 Free PMC article.
We retrospectively reviewed neonates who underwent cardiac surgery between August 2018 and July 2020 at a freestanding children's hospital, had next-generation sequencing performed, and had their cortisol levels drawn as standard clinical care after cardiac surgery. The groups we …
We retrospectively reviewed neonates who underwent cardiac surgery between August 2018 and July 2020 at a freestanding children's hospital, …
Diagnosis of adrenal failure in critically ill patients.
Moraes RB, Czepielewski MA, Friedman G, Borba EL. Moraes RB, et al. Arq Bras Endocrinol Metabol. 2011 Jun;55(5):295-302. doi: 10.1590/s0004-27302011000500001. Arq Bras Endocrinol Metabol. 2011. PMID: 21881811 Review.
Patients with CIRCI have elevated hospital morbidity and mortality. Currently, there is a wide discussion about diagnostic criteria for this dysfunction. ...With this review, we aimed at summarizing the results of the most influent papers that intended to define dia …
Patients with CIRCI have elevated hospital morbidity and mortality. Currently, there is a wide discussion about diagnostic criteria f …
Critical illness-related corticosteroid insufficiency after multiple traumas: a multicenter, prospective cohort study.
Yang Y, Liu L, Jiang D, Wang J, Ye Z, Ye J, Chao J, Zhao M, Ao D, Qiu H. Yang Y, et al. J Trauma Acute Care Surg. 2014 Jun;76(6):1390-6. doi: 10.1097/TA.0000000000000221. J Trauma Acute Care Surg. 2014. PMID: 24854306 Clinical Trial.
Most (94.7%) diagnosis of CIRCI was made in the first 48 hours after traumatic injury. The CIRCI patients had significantly more severe illness on the day of admission. At each time point, the baseline cortisol level was comparable between the CIRCI and non- …
Most (94.7%) diagnosis of CIRCI was made in the first 48 hours after traumatic injury. The CIRCI patients had significantly mo …
A Cross-Sectional Survey Study on the Diagnosis and Management of Critical Illness-Induced Corticosteroid Insufficiency in Saudi Arabia.
Qutob RA, Alaryni A, Alghamdi A, Alsolamy EN, Al Harbi K, Alammari Y, Alanazi AM, Ababtain AA, Hakami OA, Aleid ZA Jr, Alhaqbani AS, Alshehri RA, Almoshiqeh BA, Alhejazi AQ. Qutob RA, et al. Cureus. 2023 Dec 5;15(12):e49982. doi: 10.7759/cureus.49982. eCollection 2023 Dec. Cureus. 2023. PMID: 38179369 Free PMC article.
The questionnaire tool for this study was constructed based on a previous literature review. Binary logistic regression analysis was used to define factors that affect participants' knowledge of CIRCI. Results A total of 76 physicians were involved in this study. .. …
The questionnaire tool for this study was constructed based on a previous literature review. Binary logistic regression analysis was used to …
PROGNOSTIC VALUE OF LOW-DOSE ADRENOCORTICOTROPIC HORMONE TEST IN CRITICALLY ILL PATIENTS.
Abdelrehim AB, Mohsen FM, Haredi MA, Abdel Hameed Z, Ibrahim WH. Abdelrehim AB, et al. Shock. 2023 Jun 1;59(6):871-876. doi: 10.1097/SHK.0000000000002124. Epub 2023 Apr 4. Shock. 2023. PMID: 37011042
The CIRCI group had lower median survival and survival probability rates (5 days and 48.4%, respectively) compared with the non-CIRCI group (7 days and 49.5%, respectively). In addition, the CIRCI group had a shorter time to develop AKI and a higher probabili …
The CIRCI group had lower median survival and survival probability rates (5 days and 48.4%, respectively) compared with the non-CI …
Critical illness-related corticosteroid insufficiency.
Marik PE. Marik PE. Chest. 2009 Jan;135(1):181-193. doi: 10.1378/chest.08-1149. Chest. 2009. PMID: 19136406 Review.
This complex syndrome is referred to as critical illness-related corticosteroid insufficiency (CIRCI) and is defined as inadequate corticosteroid activity for the severity of the illness of a patient. The paper reviews cortisol physiology, CIRCI, and the role …
This complex syndrome is referred to as critical illness-related corticosteroid insufficiency (CIRCI) and is defined as inadeq …
Stress-dose hydrocortisone reduces critical illness-related corticosteroid insufficiency associated with severe traumatic brain injury in rats.
Chen X, Zhao Z, Chai Y, Luo L, Jiang R, Dong J, Zhang J. Chen X, et al. Crit Care. 2013 Oct 16;17(5):R241. doi: 10.1186/cc13067. Crit Care. 2013. PMID: 24131855 Free PMC article.
INTRODUCTION: The spectrum of critical illness-related corticosteroid insufficiency (CIRCI) in severe traumatic brain injury (TBI) is not fully defined and no effective treatments for TBI-induced CIRCI are available to date. ...We made the following observati …
INTRODUCTION: The spectrum of critical illness-related corticosteroid insufficiency (CIRCI) in severe traumatic brain injury (TBI) is …
The incidence of critical-illness-related-corticosteroid-insufficiency is associated with severity of traumatic brain injury in adult rats.
Chen X, Zhao Z, Chai Y, Luo L, Jiang R, Zhang J. Chen X, et al. J Neurol Sci. 2014 Jul 15;342(1-2):93-100. doi: 10.1016/j.jns.2014.04.032. Epub 2014 Apr 30. J Neurol Sci. 2014. PMID: 24819916
Traumatic brain injury (TBI) causes deleterious critical-illness-related-corticosteroid-insufficiency (CIRCI), leading to high mortality and morbidity. However, the incidence of CIRCI following different TBI severities is not fully defined. ...First, 6.7% of …
Traumatic brain injury (TBI) causes deleterious critical-illness-related-corticosteroid-insufficiency (CIRCI), leading to high mortal …
24 results