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Year Number of Results
2019 2
2020 3
2021 4
2022 2
2023 3
2024 4

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18 results

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Page 1
COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis.
Chua RL, Lukassen S, Trump S, Hennig BP, Wendisch D, Pott F, Debnath O, Thürmann L, Kurth F, Völker MT, Kazmierski J, Timmermann B, Twardziok S, Schneider S, Machleidt F, Müller-Redetzky H, Maier M, Krannich A, Schmidt S, Balzer F, Liebig J, Loske J, Suttorp N, Eils J, Ishaque N, Liebert UG, von Kalle C, Hocke A, Witzenrath M, Goffinet C, Drosten C, Laudi S, Lehmann I, Conrad C, Sander LE, Eils R. Chua RL, et al. Nat Biotechnol. 2020 Aug;38(8):970-979. doi: 10.1038/s41587-020-0602-4. Epub 2020 Jun 26. Nat Biotechnol. 2020. PMID: 32591762
In patients with COVID-19, epithelial cells showed an average three-fold increase in expression of the SARS-CoV-2 entry receptor ACE2, which correlated with interferon signals by immune cells. Compared to moderate cases, critical cases exhibited stronger interaction …
In patients with COVID-19, epithelial cells showed an average three-fold increase in expression of the SARS-CoV-2 entry receptor ACE2, which …
Inferring causation from time series in Earth system sciences.
Runge J, Bathiany S, Bollt E, Camps-Valls G, Coumou D, Deyle E, Glymour C, Kretschmer M, Mahecha MD, Muñoz-Marí J, van Nes EH, Peters J, Quax R, Reichstein M, Scheffer M, Schölkopf B, Spirtes P, Sugihara G, Sun J, Zhang K, Zscheischler J. Runge J, et al. Nat Commun. 2019 Jun 14;10(1):2553. doi: 10.1038/s41467-019-10105-3. Nat Commun. 2019. PMID: 31201306 Free PMC article. Review.
Here, we give an overview of causal inference frameworks and identify promising generic application cases common in Earth system sciences and beyond. We discuss challenges and initiate the benchmark platform causeme.net to close the gap between method users and developers. …
Here, we give an overview of causal inference frameworks and identify promising generic application cases common in Earth system scie …
Brain connectivity in major depressive disorder: a precision component of treatment modalities?
Tura A, Goya-Maldonado R. Tura A, et al. Transl Psychiatry. 2023 Jun 9;13(1):196. doi: 10.1038/s41398-023-02499-y. Transl Psychiatry. 2023. PMID: 37296121 Free PMC article. Review.
Most likely, a combination of neural variability and heterogeneity in MDD still impedes a full understanding of the disorder, as well as influences treatment success in many cases. With the help of neuroimaging methods like functional magnetic resonance imaging (fMRI) and …
Most likely, a combination of neural variability and heterogeneity in MDD still impedes a full understanding of the disorder, as well as inf …
Availability of vitamin B12 and its lower ligand intermediate α-ribazole impact prokaryotic and protist communities in oceanic systems.
Wienhausen G, Dlugosch L, Jarling R, Wilkes H, Giebel HA, Simon M. Wienhausen G, et al. ISME J. 2022 Aug;16(8):2002-2014. doi: 10.1038/s41396-022-01250-7. Epub 2022 May 18. ISME J. 2022. PMID: 35585186 Free PMC article.
Genome analyses predict that the cofactor cobalamin (vitamin B(12), called B(12) herein) is produced by only one-third of all prokaryotes but almost all encode at least one B(12)-dependent enzyme, in most cases methionine synthase. This implies that the majority of prokary …
Genome analyses predict that the cofactor cobalamin (vitamin B(12), called B(12) herein) is produced by only one-third of all prokaryotes bu …
Psilocybin-induced default mode network hypoconnectivity is blunted in alcohol-dependent rats.
Reinwald JR, Schmitz CN, Skorodumov I, Kuchar M, Weber-Fahr W, Spanagel R, Meinhardt MW. Reinwald JR, et al. Transl Psychiatry. 2023 Dec 14;13(1):392. doi: 10.1038/s41398-023-02690-1. Transl Psychiatry. 2023. PMID: 38097569 Free PMC article. Clinical Trial.
Our data suggest that a clinical standard dose of psilocybin may not be sufficient to treat severe AUD cases; a finding that should be considered for future clinical trials....
Our data suggest that a clinical standard dose of psilocybin may not be sufficient to treat severe AUD cases; a finding that should b …
Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion.
Tang Q, Gao P, Arzberger T, Höllerhage M, Herms J, Höglinger G, Koeglsperger T. Tang Q, et al. Cell Death Dis. 2021 Sep 17;12(10):854. doi: 10.1038/s41419-021-04138-0. Cell Death Dis. 2021. PMID: 34535638 Free PMC article.
In accord with our results from cultured neurons, we found a stage-dependent reduction of SNAP29 in SNc DA neurons from human post-mortem brain tissue of Lewy body pathology (LBP) cases. In summary, our results thus demonstrate a previously unknown effect of alpha-Syn on i …
In accord with our results from cultured neurons, we found a stage-dependent reduction of SNAP29 in SNc DA neurons from human post-mortem br …
A large dataset of scientific text reuse in Open-Access publications.
Gienapp L, Kircheis W, Sievers B, Stein B, Potthast M. Gienapp L, et al. Sci Data. 2023 Jan 26;10(1):58. doi: 10.1038/s41597-022-01908-z. Sci Data. 2023. PMID: 36702840 Free PMC article.
We present the Webis-STEREO-21 dataset, a massive collection of Scientific Text Reuse in Open-access publications. It contains 91 million cases of reused text passages found in 4.2 million unique open-access publications. Cases range from overlap of as few as eight …
We present the Webis-STEREO-21 dataset, a massive collection of Scientific Text Reuse in Open-access publications. It contains 91 million …
Clinical and genetic differences between bipolar disorder type 1 and 2 in multiplex families.
Guzman-Parra J, Streit F, Forstner AJ, Strohmaier J, González MJ, Gil Flores S, Cabaleiro Fabeiro FJ, Del Río Noriega F, Perez Perez F, Haro González J, Orozco Diaz G, de Diego-Otero Y, Moreno-Kustner B, Auburger G, Degenhardt F, Heilmann-Heimbach S, Herms S, Hoffmann P, Frank J, Foo JC, Sirignano L, Witt SH, Cichon S, Rivas F, Mayoral F, Nöthen MM, Andlauer TFM, Rietschel M. Guzman-Parra J, et al. Transl Psychiatry. 2021 Jan 11;11(1):31. doi: 10.1038/s41398-020-01146-0. Transl Psychiatry. 2021. PMID: 33431802 Free PMC article.
A higher BD PRS was significantly associated with suicidal ideation. Moreover, BD-I cases exhibited lower depression PRS. In line with a severity continuum from BD-II to BD-I, our results link BD-I to a more pronounced clinical presentation in both mania and depression and …
A higher BD PRS was significantly associated with suicidal ideation. Moreover, BD-I cases exhibited lower depression PRS. In line wit …
Improving personalized tumor growth predictions using a Bayesian combination of mechanistic modeling and machine learning.
Mascheroni P, Savvopoulos S, Alfonso JCL, Meyer-Hermann M, Hatzikirou H. Mascheroni P, et al. Commun Med (Lond). 2021 Jul 29;1:19. doi: 10.1038/s43856-021-00020-4. eCollection 2021. Commun Med (Lond). 2021. PMID: 35602187 Free PMC article.
In addition, we test the methodology in two additional settings dealing with real patient cohorts. In both cases, namely cancer growth in chronic lymphocytic leukemia and ovarian cancer, predictions show excellent agreement with reported clinical outcomes (around 60% reduc …
In addition, we test the methodology in two additional settings dealing with real patient cohorts. In both cases, namely cancer growt …
Cancer-specific risk prediction with a serum microRNA signature.
Raut JR, Bhardwaj M, Schöttker B, Holleczek B, Schrotz-King P, Brenner H. Raut JR, et al. Cancer Sci. 2024 Mar 24. doi: 10.1111/cas.16135. Online ahead of print. Cancer Sci. 2024. PMID: 38523358 Free article.
MicroRNAs (miRNAs) were profiled by quantitative real-time PCR in serum samples collected at baseline from randomly selected incident cases of BC (n = 90), LC (n = 88), and PC (n = 93) and participants without diagnosis of CRC, LC, BC, or PC (controls, n = 181) until the e …
MicroRNAs (miRNAs) were profiled by quantitative real-time PCR in serum samples collected at baseline from randomly selected incident cas …
18 results