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Year Number of Results
1988 1
2000 2
2001 1
2009 2
2011 3
2013 2
2014 3
2015 2
2016 4
2017 12
2018 8
2019 11
2020 13
2021 15
2022 26
2023 18
2024 8

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116 results

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Page 1
Empagliflozin in Patients with Chronic Kidney Disease.
The EMPA-KIDNEY Collaborative Group; Herrington WG, Staplin N, Wanner C, Green JB, Hauske SJ, Emberson JR, Preiss D, Judge P, Mayne KJ, Ng SYA, Sammons E, Zhu D, Hill M, Stevens W, Wallendszus K, Brenner S, Cheung AK, Liu ZH, Li J, Hooi LS, Liu W, Kadowaki T, Nangaku M, Levin A, Cherney D, Maggioni AP, Pontremoli R, Deo R, Goto S, Rossello X, Tuttle KR, Steubl D, Petrini M, Massey D, Eilbracht J, Brueckmann M, Landray MJ, Baigent C, Haynes R. The EMPA-KIDNEY Collaborative Group, et al. N Engl J Med. 2023 Jan 12;388(2):117-127. doi: 10.1056/NEJMoa2204233. Epub 2022 Nov 4. N Engl J Med. 2023. PMID: 36331190 Free PMC article. Clinical Trial.
Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus.
Cheng L, Wang J, Dai H, Duan Y, An Y, Shi L, Lv Y, Li H, Wang C, Ma Q, Li Y, Li P, Du H, Zhao B. Cheng L, et al. Adipocyte. 2021 Dec;10(1):48-65. doi: 10.1080/21623945.2020.1870060. Adipocyte. 2021. PMID: 33403891 Free PMC article. Review.
White adipocytes display high plasticity and can transdifferentiate into beige adipocytes which have many similar morphological and functional properties with brown adipocytes under the stimulations of exercise, cold exposure and other factors. This phenomenon is also know …
White adipocytes display high plasticity and can transdifferentiate into beige adipocytes which have many similar morphological and f …
SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by facilitating PRDM16-PPARgamma complex.
Shen H, He T, Wang S, Hou L, Wei Y, Liu Y, Mo C, Zhao Z, You W, Guo H, Li B. Shen H, et al. Theranostics. 2022 Nov 7;12(18):7699-7716. doi: 10.7150/thno.77102. eCollection 2022. Theranostics. 2022. PMID: 36451857 Free PMC article.
Brown and beige fat protect against cold environments and obesity by catabolizing stored energy to generate heat. ...At the cell level, loss of SOX4 from preadipocytes inhibited the development of beige adipocytes, and loss of SOX4 from mature beige adipocyte …
Brown and beige fat protect against cold environments and obesity by catabolizing stored energy to generate heat. ...At the cell leve …
Local hyperthermia therapy induces browning of white fat and treats obesity.
Li Y, Wang D, Ping X, Zhang Y, Zhang T, Wang L, Jin L, Zhao W, Guo M, Shen F, Meng M, Chen X, Zheng Y, Wang J, Li D, Zhang Q, Hu C, Xu L, Ma X. Li Y, et al. Cell. 2022 Mar 17;185(6):949-966.e19. doi: 10.1016/j.cell.2022.02.004. Epub 2022 Mar 4. Cell. 2022. PMID: 35247329 Free article.
Beige fat plays key roles in the regulation of systemic energy homeostasis; however, detailed mechanisms and safe strategy for its activation remain elusive. In this study, we discovered that local hyperthermia therapy (LHT) targeting beige fat promoted its activati …
Beige fat plays key roles in the regulation of systemic energy homeostasis; however, detailed mechanisms and safe strategy for its ac …
The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice.
Jin L, Han S, Lv X, Li X, Zhang Z, Kuang H, Chen Z, Lv CA, Peng W, Yang Z, Yang M, Mi L, Liu T, Ma S, Qiu X, Wang Q, Pan X, Shan P, Feng Y, Li J, Wang F, Xie L, Zhao X, Fu JF, Lin JD, Meng ZX. Jin L, et al. Nat Commun. 2023 Jul 19;14(1):4257. doi: 10.1038/s41467-023-39710-z. Nat Commun. 2023. PMID: 37468484 Free PMC article.
Muscle-transgenic or AAV-mediated overexpression of Musclin attenuates beige fat thermogenesis, thereby exacerbating diet-induced obesity and metabolic disorders in male mice. Conversely, Musclin inactivation by muscle-specific ablation or neutralizing antibody treatment p …
Muscle-transgenic or AAV-mediated overexpression of Musclin attenuates beige fat thermogenesis, thereby exacerbating diet-induced obe …
Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis.
Huang X, Li X, Shen H, Zhao Y, Zhou Z, Wang Y, Yao J, Xue K, Wu D, Qiu Y. Huang X, et al. Nat Commun. 2023 Nov 4;14(1):7102. doi: 10.1038/s41467-023-43021-8. Nat Commun. 2023. PMID: 37925548 Free PMC article.
Here, we show that adipocyte YAP/TAZ inhibit sympathetic innervation of beige fat by transcriptional repression of neurotropic factor S100B. ...Together, our data reveal that YAP/TAZ act as a brake on the beige fat innervation by blocking PRDM16-C/EBPbeta-mediated S …
Here, we show that adipocyte YAP/TAZ inhibit sympathetic innervation of beige fat by transcriptional repression of neurotropic factor …
Insulin signaling establishes a developmental trajectory of adipose regulatory T cells.
Li Y, Lu Y, Lin SH, Li N, Han Y, Huang Q, Zhao Y, Xie F, Guo Y, Deng B, Tsun A, Du J, Li D, Sun J, Shi G, Zheng F, Su X, Duan S, Zheng SG, Wang G, Tong X, Li B. Li Y, et al. Nat Immunol. 2021 Sep;22(9):1175-1185. doi: 10.1038/s41590-021-01010-3. Epub 2021 Aug 24. Nat Immunol. 2021. PMID: 34429546
T(reg) cells deficient in insulin receptor, HIF-1alpha or Med23 have decreased PPAR-gamma expression that in turn promotes accumulation of CD73(hi)ST2(lo) adipose T(reg) cells and physiological adenosine production to activate beige fat biogenesis. We therefore unveiled a …
T(reg) cells deficient in insulin receptor, HIF-1alpha or Med23 have decreased PPAR-gamma expression that in turn promotes accumulation of C …
Obesity caused by an OVOL2 mutation reveals dual roles of OVOL2 in promoting thermogenesis and limiting white adipogenesis.
Zhang Z, Jiang Y, Su L, Ludwig S, Zhang X, Tang M, Li X, Anderton P, Zhan X, Choi M, Russell J, Bu CH, Lyon S, Xu D, Hildebrand S, Scott L, Quan J, Simpson R, Sun Q, Qin B, Collie T, Tadesse M, Moresco EMY, Beutler B. Zhang Z, et al. Cell Metab. 2022 Nov 1;34(11):1860-1874.e4. doi: 10.1016/j.cmet.2022.09.018. Epub 2022 Oct 12. Cell Metab. 2022. PMID: 36228616 Free PMC article.
OVOL2-deficient mice were extremely cold intolerant. OVOL2 is essential for brown/beige adipose tissue-mediated thermogenesis. In white adipose tissues, OVOL2 limited adipogenesis by blocking C/EBPalpha engagement of its transcriptional targets. ...
OVOL2-deficient mice were extremely cold intolerant. OVOL2 is essential for brown/beige adipose tissue-mediated thermogenesis. In whi …
Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway.
Wu T, Liu Q, Li Y, Li H, Chen L, Yang X, Tang Q, Pu S, Kuang J, Li R, Huang Y, Zhang J, Zhang Z, Zhou J, Huang C, Zhang G, Zhao Y, Zou M, Jiang W, Mo L, He J. Wu T, et al. J Exp Med. 2021 Jun 7;218(6):e20201203. doi: 10.1084/jem.20201203. J Exp Med. 2021. PMID: 33856409 Free PMC article.
Activating beige adipocytes in white adipose tissue (WAT) to increase energy expenditure is a promising strategy to combat obesity. ...
Activating beige adipocytes in white adipose tissue (WAT) to increase energy expenditure is a promising strategy to combat obesity. . …
MYPT1-PP1beta phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis.
Takahashi H, Yang G, Yoneshiro T, Abe Y, Ito R, Yang C, Nakazono J, Okamoto-Katsuyama M, Uchida A, Arai M, Jin H, Choi H, Tumenjargal M, Xie S, Zhang J, Sagae H, Zhao Y, Yamaguchi R, Nomura Y, Shimizu Y, Yamada K, Yasuda S, Kimura H, Tanaka T, Wada Y, Kodama T, Aburatani H, Zhu MS, Inagaki T, Osborne TF, Kawamura T, Ishihama Y, Matsumura Y, Sakai J. Takahashi H, et al. Nat Commun. 2022 Sep 29;13(1):5715. doi: 10.1038/s41467-022-33363-0. Nat Commun. 2022. PMID: 36175407 Free PMC article.
Protein kinase A promotes beige adipogenesis downstream from beta-adrenergic receptor signaling by phosphorylating proteins, including histone H3 lysine 9 (H3K9) demethylase JMJD1A. ...We show that myosin phosphatase target subunit 1- protein phosphatase 1beta (MYPT1-PP1be …
Protein kinase A promotes beige adipogenesis downstream from beta-adrenergic receptor signaling by phosphorylating proteins, includin …
116 results