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Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression.
Yan R, Ge X, Pang N, Ye H, Yuan L, Cheng B, Zhou K, Yang M, Sun Y, Zhang S, Ding Z, Luo J, Ruan C, Dai K. Yan R, et al. Cell Death Dis. 2021 Oct 16;12(11):955. doi: 10.1038/s41419-021-04246-x. Cell Death Dis. 2021. PMID: 34657146 Free PMC article.
Zyxin is upregulated during megakaryocytic differentiation; however, the role of zyxin in thrombopoiesis is unknown. ...Reconstitution of zyxin with VASP binding site in zyxin-deficient hematopoietic progenitor cell-derived MKs restored GPIb-IX surface …
Zyxin is upregulated during megakaryocytic differentiation; however, the role of zyxin in thrombopoiesis is unknown. ...Recons …
Zyxin Is Involved in Fibroblast Rigidity Sensing and Durotaxis.
Yip AK, Zhang S, Chong LH, Cheruba E, Woon JYX, Chua TX, Goh CJH, Yang H, Tay CY, Koh CG, Chiam KH. Yip AK, et al. Front Cell Dev Biol. 2021 Nov 18;9:735298. doi: 10.3389/fcell.2021.735298. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34869319 Free PMC article.
Cell migration speed of zyxin knockdown fibroblasts was also independent of the underlying substrate rigidity, unlike wild type fibroblasts which migrated fastest at an intermediate substrate rigidity of 14 kPa. Wild type fibroblasts exhibited durotaxis by migrating toward …
Cell migration speed of zyxin knockdown fibroblasts was also independent of the underlying substrate rigidity, unlike wild type fibro …
Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules.
Han X, Li P, Yang Z, Huang X, Wei G, Sun Y, Kang X, Hu X, Deng Q, Chen L, He A, Huo Y, Li D, Betzig E, Luo J. Han X, et al. Nat Commun. 2017 Mar 3;8:14639. doi: 10.1038/ncomms14639. Nat Commun. 2017. PMID: 28256511 Free PMC article.
Zyxin-deficient mice exhibit impaired epinephrine-stimulated VWF release, prolonged bleeding time and thrombosis, largely due to defective endothelial secretion of VWF. ...Our findings identify zyxin as a physiological regulator of endothelial exocytosis through reo …
Zyxin-deficient mice exhibit impaired epinephrine-stimulated VWF release, prolonged bleeding time and thrombosis, largely due to defe …
Variants of Focal Adhesion Scaffold Genes Cause Thoracic Aortic Aneurysm.
Li Y, Gao S, Han Y, Song L, Kong Y, Jiao Y, Huang S, Du J, Li Y. Li Y, et al. Circ Res. 2021 Jan 8;128(1):8-23. doi: 10.1161/CIRCRESAHA.120.317361. Epub 2020 Oct 23. Circ Res. 2021. PMID: 33092471 Free article.
Interestingly, suspected functional variants of other focal adhesion scaffold genes, including TLN1 (Talin-1) and ZYX (zyxin), were also significantly enriched in patients with iTAA; moreover, their knockdown resulted in decreased contractility of vascular smooth muscle ce …
Interestingly, suspected functional variants of other focal adhesion scaffold genes, including TLN1 (Talin-1) and ZYX (zyxin), were a …
[The Role of Zyxin in Regulating Platelet Cytoskeleton Distribution].
Cheng B, Yan R, Zhang SQ, Yang MN, Dai KS. Cheng B, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2021 Jun;29(3):876-880. doi: 10.19746/j.cnki.issn.1009-2137.2021.03.035. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2021. PMID: 34105487 Chinese.
OBJECTIVE: To investigate the regulatory effect of zyxin on the distribution of platelet cytoskeleton. METHODS: Platelets were isolated from zyxin-knockout (Zyx(-/-)) and wild type (WT) mice respectively and corresponding platelet cytoskeleton components were separa …
OBJECTIVE: To investigate the regulatory effect of zyxin on the distribution of platelet cytoskeleton. METHODS: Platelets were isolat …
Zyxin-involved actin regulation is essential in the maintenance of vinculin focal adhesion and chondrocyte differentiation status.
Li G, Song X, Li R, Sun L, Gong X, Chen C, Yang L. Li G, et al. Cell Prolif. 2019 Jan;52(1):e12532. doi: 10.1111/cpr.12532. Epub 2018 Oct 17. Cell Prolif. 2019. PMID: 30328655 Free PMC article.
CONCLUSIONS: These results demonstrate supporting evidence that in chondrocytes the level of zyxin is closely associated with the state of actin polymerization. In particular, the change of zyxin and F-actin parallels with the change of COL II and vinculin, respecti …
CONCLUSIONS: These results demonstrate supporting evidence that in chondrocytes the level of zyxin is closely associated with the sta …
Zyxin (ZYX) promotes invasion and acts as a biomarker for aggressive phenotypes of human glioblastoma multiforme.
Wen XM, Luo T, Jiang Y, Wang LH, Luo Y, Chen Q, Yang K, Yuan Y, Luo C, Zhang X, Yan ZX, Fu WJ, Tan YH, Niu Q, Xiao JF, Chen L, Wang J, Huang JF, Cui YH, Zhang X, Wang Y, Bian XW. Wen XM, et al. Lab Invest. 2020 Jun;100(6):812-823. doi: 10.1038/s41374-019-0368-9. Epub 2020 Jan 16. Lab Invest. 2020. PMID: 31949244 Free article.
Since cytoskeleton proteins are related to leading processes and cell motility, and through analysis of public GBM databases, we determined that an actin-interacting protein, zyxin (ZYX), may involved in GBM invasion. Our own glioma cohort as well as the cancer genome atla …
Since cytoskeleton proteins are related to leading processes and cell motility, and through analysis of public GBM databases, we determined …
Increased Expression of Zyxin and Its Potential Function in Androgenetic Alopecia.
Liu Q, Shi X, Zhang Y, Huang Y, Yang K, Tang Y, Ma Y, Zhang Y, Wang J, Zhang L, Zhang Q, Liu X, Lin J, Wang J, Wu W. Liu Q, et al. Front Cell Dev Biol. 2021 Jan 11;8:582282. doi: 10.3389/fcell.2020.582282. eCollection 2020. Front Cell Dev Biol. 2021. PMID: 33505959 Free PMC article.
Previous studies have revealed that adhesion signals are important factors in AGA development. Zyxin (ZYX) is an actin-interacting protein that is essential for cell adhesion and migration. ...
Previous studies have revealed that adhesion signals are important factors in AGA development. Zyxin (ZYX) is an actin-interacting pr …
Zyxin as a potential cancer prognostic marker promotes the proliferation and metastasis of colorectal cancer cells.
Zhong C, Yu J, Li D, Jiang K, Tang Y, Yang M, Shen H, Fang X, Ding K, Zheng S, Yuan Y. Zhong C, et al. J Cell Physiol. 2019 Sep;234(9):15775-15789. doi: 10.1002/jcp.28236. Epub 2019 Jan 29. J Cell Physiol. 2019. PMID: 30697742
This study was conducted to investigate the functions and mechanisms of Zyxin (ZYX) in CRC. Multiomics analysis associated ZYX with CRC metastasis. ...
This study was conducted to investigate the functions and mechanisms of Zyxin (ZYX) in CRC. Multiomics analysis associated ZYX with C …
Drug resistance‑related gene targets and molecular mechanisms in the A2780/Taxol‑resistant epithelial ovarian cancer cell line.
Yang R, Zhang H, Chen Z, Zhang T, Wei P, Liang H, He Y, Zheng C, Wang X, Zhang Y. Yang R, et al. Oncol Lett. 2024 Mar 26;27(5):232. doi: 10.3892/ol.2024.14365. eCollection 2024 May. Oncol Lett. 2024. PMID: 38586210 Free PMC article.
Further bioinformatics analysis revealed that matrix metalloproteinase 1 (MMP1), zyxin (ZYX) and Unc-5 netrin receptor C (UNC5C) may be gene targets related to paclitaxel resistance. ...
Further bioinformatics analysis revealed that matrix metalloproteinase 1 (MMP1), zyxin (ZYX) and Unc-5 netrin receptor C (UNC5C) may …
18 results