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Enhancement of Zyxin Promotes Skin Fibrosis by Regulating FAK/PI3K/AKT and TGF-beta Signaling Pathways via Integrins.
Huang Y, Zhao H, Zhang Y, Tang Y, Shi X, Jiang S, Pu W, Liu J, Ma Y, Lin J, Lin J, Wu W, Gong Y, Wang J, Liu Q. Huang Y, et al. Int J Biol Sci. 2023 Apr 29;19(8):2394-2408. doi: 10.7150/ijbs.77649. eCollection 2023. Int J Biol Sci. 2023. PMID: 37215989 Free PMC article.
Moreover, we found Zyxin inhibition could significantly alleviate skin fibrosis using Zyxin knock-down and knock-out mice, nude mouse model and skin explants of human keloid. Double immunofluorescence staining showed that Zyxin was highly expressed in fibrobl …
Moreover, we found Zyxin inhibition could significantly alleviate skin fibrosis using Zyxin knock-down and knock-out mice, nud …
Zyxin: a mechanotransductor to regulate gene expression.
Wang YX, Wang DY, Guo YC, Guo J. Wang YX, et al. Eur Rev Med Pharmacol Sci. 2019 Jan;23(1):413-425. doi: 10.26355/eurrev_201901_16790. Eur Rev Med Pharmacol Sci. 2019. PMID: 30657586 Free article. Review.
Growing evidence suggests that zyxin is a vital mechanotransductor to regulate the gene expression. In this review, we summarize the features of zyxin and the molecular mechanism of how zyxin participate in the cellular activity. ...
Growing evidence suggests that zyxin is a vital mechanotransductor to regulate the gene expression. In this review, we summarize the …
Upregulated Cytoskeletal Proteins Promote Pathological Angiogenesis in Moyamoya Disease.
He S, Zhang J, Liu Z, Wang Y, Hao X, Wang X, Zhou Z, Ye X, Zhao Y, Zhao Y, Wang R. He S, et al. Stroke. 2023 Dec;54(12):3153-3164. doi: 10.1161/STROKEAHA.123.044476. Epub 2023 Oct 27. Stroke. 2023. PMID: 37886851
RESULTS: Proteomic analysis showed that a total of 14 726 peptides and 1555 proteins were quantified by mass spectrometry data. FLNA (filamin A) and ZYX (zyxin) proteins were significantly higher in MMD serum compared with those in health controls (Log(2)FC >2.9 and &gt …
RESULTS: Proteomic analysis showed that a total of 14 726 peptides and 1555 proteins were quantified by mass spectrometry data. FLNA (filami …
Zyxin and paxillin proteins: focal adhesion plaque LIM domain proteins go nuclear.
Wang Y, Gilmore TD. Wang Y, et al. Biochim Biophys Acta. 2003 Feb 17;1593(2-3):115-20. doi: 10.1016/s0167-4889(02)00349-x. Biochim Biophys Acta. 2003. PMID: 12581855 Free article. Review.
However, recent work has shown that zyxin/paxillin family proteins also shuttle through the nucleus. ...In some cases, misregulation of nuclear functions of zyxin/paxillin proteins appear to be associated with pathogenic effects....
However, recent work has shown that zyxin/paxillin family proteins also shuttle through the nucleus. ...In some cases, misregulation …
Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation.
Zhou J, Zeng Y, Cui L, Chen X, Stauffer S, Wang Z, Yu F, Lele SM, Talmon GA, Black AR, Chen Y, Dong J. Zhou J, et al. Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6760-E6769. doi: 10.1073/pnas.1800621115. Epub 2018 Jul 2. Proc Natl Acad Sci U S A. 2018. PMID: 29967145 Free PMC article.
However, little is known about the mechanisms by which Zyxin itself is regulated and how Zyxin affects Hippo-YAP activity. ...Mitotic phosphorylation is required for Zyxin activity in promoting growth. Zyxin regulates YAP activity through the colon can …
However, little is known about the mechanisms by which Zyxin itself is regulated and how Zyxin affects Hippo-YAP activity. ... …
TRIP6 functions in brain ciliogenesis.
Shukla S, Haenold R, Urbánek P, Frappart L, Monajembashi S, Grigaravicius P, Nagel S, Min WK, Tapias A, Kassel O, Heuer H, Wang ZQ, Ploubidou A, Herrlich P. Shukla S, et al. Nat Commun. 2021 Oct 7;12(1):5887. doi: 10.1038/s41467-021-26057-6. Nat Commun. 2021. PMID: 34620853 Free PMC article.
TRIP6, a member of the ZYXIN-family of LIM domain proteins, is a focal adhesion component. ...
TRIP6, a member of the ZYXIN-family of LIM domain proteins, is a focal adhesion component. ...
Zyxin (ZYX) promotes invasion and acts as a biomarker for aggressive phenotypes of human glioblastoma multiforme.
Wen XM, Luo T, Jiang Y, Wang LH, Luo Y, Chen Q, Yang K, Yuan Y, Luo C, Zhang X, Yan ZX, Fu WJ, Tan YH, Niu Q, Xiao JF, Chen L, Wang J, Huang JF, Cui YH, Zhang X, Wang Y, Bian XW. Wen XM, et al. Lab Invest. 2020 Jun;100(6):812-823. doi: 10.1038/s41374-019-0368-9. Epub 2020 Jan 16. Lab Invest. 2020. PMID: 31949244 Free article.
Since cytoskeleton proteins are related to leading processes and cell motility, and through analysis of public GBM databases, we determined that an actin-interacting protein, zyxin (ZYX), may involved in GBM invasion. Our own glioma cohort as well as the cancer genome atla …
Since cytoskeleton proteins are related to leading processes and cell motility, and through analysis of public GBM databases, we determined …
Increased Expression of Zyxin and Its Potential Function in Androgenetic Alopecia.
Liu Q, Shi X, Zhang Y, Huang Y, Yang K, Tang Y, Ma Y, Zhang Y, Wang J, Zhang L, Zhang Q, Liu X, Lin J, Wang J, Wu W. Liu Q, et al. Front Cell Dev Biol. 2021 Jan 11;8:582282. doi: 10.3389/fcell.2020.582282. eCollection 2020. Front Cell Dev Biol. 2021. PMID: 33505959 Free PMC article.
Previous studies have revealed that adhesion signals are important factors in AGA development. Zyxin (ZYX) is an actin-interacting protein that is essential for cell adhesion and migration. ...
Previous studies have revealed that adhesion signals are important factors in AGA development. Zyxin (ZYX) is an actin-interacting pr …
TRIP6 a potential diagnostic marker for colorectal cancer with glycolysis and immune infiltration association.
Liu XS, Chen YX, Wan HB, Wang YL, Wang YY, Gao Y, Wu LB, Pei ZJ. Liu XS, et al. Sci Rep. 2024 Feb 19;14(1):4042. doi: 10.1038/s41598-024-54670-0. Sci Rep. 2024. PMID: 38369589 Free PMC article.
Thyroid hormone receptor interactor 6 (TRIP6) it is an adaptor protein belonging to the zyxin family of LIM proteins, participating in signaling events through interactions with various molecules. ...
Thyroid hormone receptor interactor 6 (TRIP6) it is an adaptor protein belonging to the zyxin family of LIM proteins, participating i …
Nanoscale architecture of cadherin-based cell adhesions.
Bertocchi C, Wang Y, Ravasio A, Hara Y, Wu Y, Sailov T, Baird MA, Davidson MW, Zaidel-Bar R, Toyama Y, Ladoux B, Mege RM, Kanchanawong P. Bertocchi C, et al. Nat Cell Biol. 2017 Jan;19(1):28-37. doi: 10.1038/ncb3456. Epub 2016 Dec 19. Nat Cell Biol. 2017. PMID: 27992406 Free PMC article.
Vinculin position is determined by alpha-catenin, and following activation, vinculin can extend 30 nm to bridge the cadherin-catenin and actin compartments, while modulating the nanoscale positions of the actin regulators zyxin and VASP. Vinculin conformational activation …
Vinculin position is determined by alpha-catenin, and following activation, vinculin can extend 30 nm to bridge the cadherin-catenin and act …
46 results