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A pandemic recap: lessons we have learned.
Coccolini F, Cicuttin E, Cremonini C, Tartaglia D, Viaggi B, Kuriyama A, Picetti E, Ball C, Abu-Zidan F, Ceresoli M, Turri B, Jain S, Palombo C, Guirao X, Rodrigues G, Gachabayov M, Machado F, Eftychios L, Kanj SS, Di Carlo I, Di Saverio S, Khokha V, Kirkpatrick A, Massalou D, Forfori F, Corradi F, Delibegovic S, Machain Vega GM, Fantoni M, Demetriades D, Kapoor G, Kluger Y, Ansari S, Maier R, Leppaniemi A, Hardcastle T, Vereczkei A, Karamagioli E, Pikoulis E, Pistello M, Sakakushev BE, Navsaria PH, Galeiras R, Yahya AI, Osipov AV, Dimitrov E, Doklestić K, Pisano M, Malacarne P, Carcoforo P, Sibilla MG, Kryvoruchko IA, Bonavina L, Kim JI, Shelat VG, Czepiel J, Maseda E, Marwah S, Chirica M, Biancofiore G, Podda M, Cobianchi L, Ansaloni L, Fugazzola P, Seretis C, Gomez CA, Tumietto F, Malbrain M, Reichert M, Augustin G, Amato B, Puzziello A, Hecker A, Gemignani A, Isik A, Cucchetti A, Nacoti M, Kopelman D, Mesina C, Ghannam W, Ben-Ishay O, Dhingra S, Coimbra R, Moore EE, Cui Y, Quiodettis MA, Bala M, Testini M, Diaz J, Girardis M, Biffl WL, Hecker M, Sall I, Boggi U, Materazzi G, Ghiadoni L, Matsumoto J, Zuidema WP, Ivatury R, Enani MA, Litvin A, Al-Hasan MN, Demetrashvili Z, Barak… See abstract for full author list ➔ Coccolini F, et al. World J Emerg Surg. 2021 Sep 10;16(1):46. doi: 10.1186/s13017-021-00393-w. World J Emerg Surg. 2021. PMID: 34507603 Free PMC article.
Molecular overlay-guided design of new CDK2 inhibitor thiazepinopurines: Synthesis, anticancer, and mechanistic investigations.
Husseiny EM, Abulkhair HS, Saleh A, Altwaijry N, Zidan RA, Abdulrahman FG. Husseiny EM, et al. Bioorg Chem. 2023 Nov;140:106789. doi: 10.1016/j.bioorg.2023.106789. Epub 2023 Aug 17. Bioorg Chem. 2023. PMID: 37611530
Additionally, both compounds displayed superior selectivity indices (SI = 3.00-7.15) toward tested cancer cells. The 4-chlorophenyl analog 3b has shown the best selectivity index, and hence it has been subjected to additional investigations to determine its proper mechanis …
Additionally, both compounds displayed superior selectivity indices (SI = 3.00-7.15) toward tested cancer cells. The 4-chlorophenyl a …
New pyrazolyl-thiazolidinone/thiazole derivatives as celecoxib/dasatinib analogues with selective COX-2, HER-2 and EGFR inhibitory effects: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis, molecular modelling and ADME studies.
Fadaly WAA, Zidan TH, Kahk NM, Mohamed FEA, Abdelhakeem MM, Khalil RG, Nemr MTM. Fadaly WAA, et al. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2281262. doi: 10.1080/14756366.2023.2281262. Epub 2023 Nov 27. J Enzyme Inhib Med Chem. 2023. PMID: 38010912 Free PMC article.
New 1,2,3-triazole/1,2,4-triazole hybrids linked to oxime moiety as nitric oxide donor selective COX-2, aromatase, B-RAFV600E and EGFR inhibitors celecoxib analogs: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis and molecular modeling study.
Fadaly WAA, Nemr MTM, Zidan TH, Mohamed FEA, Abdelhakeem MM, Abu Jayab NN, Omar HA, Abdellatif KRA. Fadaly WAA, et al. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2290461. doi: 10.1080/14756366.2023.2290461. Epub 2023 Dec 7. J Enzyme Inhib Med Chem. 2023. PMID: 38061801 Free PMC article.
Synthesis of novel halogenated triarylpyrazoles as selective COX-2 inhibitors: Anti-inflammatory activity, histopatholgical profile and in-silico studies.
Abdellatif KRA, Abdelall EKA, Labib MB, Fadaly WAA, Zidan TH. Abdellatif KRA, et al. Bioorg Chem. 2020 Dec;105:104418. doi: 10.1016/j.bioorg.2020.104418. Epub 2020 Oct 22. Bioorg Chem. 2020. PMID: 33166844
All target compounds showed good in vitro COX-2 inhibitory activity (IC(50) = 0.043-0.17 M) over COX-1 (IC(50) = 7.8 - 15.4 M) relative to celecoxib (COX-1/IC(50) = 9.87, COX-2/IC(50) = 0.055), with acceptable selectivity index values (SI = 50.6-253.1). Also, they displaye …
All target compounds showed good in vitro COX-2 inhibitory activity (IC(50) = 0.043-0.17 M) over COX-1 (IC(50) = 7.8 - 15.4 M) relative to c …
Synthesis and Biological Evaluation of New Diarylpyrazole and Triarylimidazoline Derivatives as Selective COX-2 Inhibitors.
Abdellatif KRA, Abdelgawad MA, Labib MB, Zidan TH. Abdellatif KRA, et al. Arch Pharm (Weinheim). 2017 Aug;350(8). doi: 10.1002/ardp.201600386. Epub 2017 Jun 12. Arch Pharm (Weinheim). 2017. PMID: 28605057
The synthesized compounds showed good selectivity for COX-2; compounds 8a, 8d, 8f, 11a, and 11c exhibited the highest COX-2 selectivity indexes (SI = 4.77-5.43) compared to the reference drug celecoxib (SI = 7.8). ...
The synthesized compounds showed good selectivity for COX-2; compounds 8a, 8d, 8f, 11a, and 11c exhibited the highest COX-2 selectivity inde …