Two pairs of epimeric indole alkaloids from Catharanthus roseus

Planta Med. 2011 Oct;77(15):1739-41. doi: 10.1055/s-0030-1271064. Epub 2011 May 3.

Abstract

Two pairs of epimeric indole alkaloids (1- 4) with a chlorine atom were isolated from the aerial part of Catharanthus roseus. Their structures were established on the basis of the spectroscopic data including UV, IR, HRESIMS, NMR, and X-ray diffraction analyses. The cytotoxic activities of 1-4 against the HepG2 cell line were evaluated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology
  • Catharanthus / chemistry*
  • Cell Survival
  • Hep G2 Cells
  • Humans
  • Indole Alkaloids / chemistry*
  • Indole Alkaloids / isolation & purification
  • Indole Alkaloids / pharmacology
  • Isomerism
  • Magnetic Resonance Spectroscopy
  • Medicine, Chinese Traditional
  • Molecular Structure
  • Plant Components, Aerial / chemistry
  • Plant Extracts / chemistry*
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • X-Ray Diffraction

Substances

  • Antineoplastic Agents
  • Indole Alkaloids
  • Plant Extracts