Abstract
The first synthesis of 4'-selenonucleosides was achieved using a Pummerer-type condensation as a key step. All stereoelectronic effects shown in 4'-oxonucleosides were overwhelmed by the size of selenium and steric interactions, driving the conformation to the C2'-endo/ C3'-exo twist (Southern) conformation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Crystallography, X-Ray
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Models, Molecular
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Molecular Structure
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Nucleic Acid Conformation
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Nucleosides / chemical synthesis*
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Nucleosides / chemistry
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Organoselenium Compounds / chemical synthesis*
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Organoselenium Compounds / chemistry
Substances
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Nucleosides
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Organoselenium Compounds