Synthesis and biological evaluation of C-12' substituted vinflunine derivatives

Xin Sheng Lei; Xiang Da Yu; Long Yin; Zhen Hong Liu; Peng Cho Tang

doi:10.1016/j.bmcl.2008.07.025

Synthesis and biological evaluation of C-12' substituted vinflunine derivatives

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4602-5. doi: 10.1016/j.bmcl.2008.07.025. Epub 2008 Jul 12.

Authors

Xin Sheng Lei¹, Xiang Da Yu, Long Yin, Zhen Hong Liu, Peng Cho Tang

Affiliation

¹ Shanghai Hengrui Pharmaceuticals Co., Ltd., 279 Wenjing Road, Shanghai 200245, China.

PMID: 18653334
DOI: 10.1016/j.bmcl.2008.07.025

Abstract

A series of novel C-12' substituted vinflunine derivatives have been synthesized. Several compounds in this series possess comparable in vitro cytotoxic potency against A549 cell lines.

MeSH terms

Antineoplastic Agents, Phytogenic / chemical synthesis*
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Line, Tumor
Chemistry, Pharmaceutical / methods*
Drug Design
Drug Screening Assays, Antitumor*
Humans
Inhibitory Concentration 50
Microtubules / chemistry
Models, Chemical
Molecular Conformation
Sodium Azide / pharmacology
Tubulin / chemistry
Vinblastine / analogs & derivatives*
Vinblastine / chemical synthesis
Vinblastine / chemistry
Vinblastine / pharmacology

Substances

Antineoplastic Agents, Phytogenic
Tubulin
vinflunine
Vinblastine
Sodium Azide