SIRT1 alleviates IL-1β induced nucleus pulposus cells pyroptosis via mitophagy in intervertebral disc degeneration.
Ma Z, Tang P, Dong W, Lu Y, Tan B, Zhou N, Hao J, Shen J, Hu Z.
Ma Z, et al.
Int Immunopharmacol. 2022 Jun;107:108671. doi: 10.1016/j.intimp.2022.108671. Epub 2022 Mar 16.
Int Immunopharmacol. 2022.
PMID: 35305383
SIRT1 overexpression could ameliorate IL-1beta induced mitochondrial dysfunction and ROS accumulation, inhibit NLRP3 inflammasome activation by promoting PINK1/Parkin mediated mitophagy, however, these protective phenomena reversed by autophagy inhibitor 3-MA pretreatment. …
SIRT1 overexpression could ameliorate IL-1beta induced mitochondrial dysfunction and ROS accumulation, inhibit NLRP3 inflammasome activation …