A novel methodology for analysis of enantiomers through determination of their critical micelle concentrations using spectrophotometric method

Ghodratollah Absalan; Yousef Alipour

doi:10.1016/j.jpba.2013.04.034

A novel methodology for analysis of enantiomers through determination of their critical micelle concentrations using spectrophotometric method

J Pharm Biomed Anal. 2013 Sep:83:96-100. doi: 10.1016/j.jpba.2013.04.034. Epub 2013 Apr 30.

Authors

Ghodratollah Absalan¹, Yousef Alipour

Affiliation

¹ Professor Massoumi Laboratory, Department of Chemistry, Faculty of Sciences, Shiraz University, Shiraz 71454, Iran. gubsulun@yahoo.com

PMID: 23708436
DOI: 10.1016/j.jpba.2013.04.034

Abstract

A novel methodology for analysis of enantiomer composition of chiral compounds based on measuring of their critical micelle concentration by using spectrophotometric technique is introduced. The proposed method does not require any chiral selector and the corresponding process is simple, fast, reproducible, and inexpensive. The procedure was successfully applied for analysis of naproxen. The critical micelle concentration data showed that (R)-naproxen could be determined with an RSD of 1.1% and a relative error of -5.6% when a real sample containing the racemic mixture of naproxen with a total concentration of 0.04 mM was tested.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Hydrogen-Ion Concentration
Micelles
Naproxen / chemistry*
Osmolar Concentration
Spectrophotometry / methods*
Temperature

Substances

Micelles
Naproxen