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Page 1
Measurement of neutral ceramidase activity in vitro and in vivo.
Simoes M, Saleh A, Choi YM, Airola MV, Haley JD, Coant N. Simoes M, et al. Among authors: choi ym. Anal Biochem. 2022 Apr 15;643:114577. doi: 10.1016/j.ab.2022.114577. Epub 2022 Feb 5. Anal Biochem. 2022. PMID: 35134389 Review.
Neutral ceramidase-active site inhibitor chemotypes and binding modes.
Coant N, Bickel JD, Rahaim R, Otsuka Y, Choi YM, Xu R, Simoes M, Cariello C, Mao C, Saied EM, Arenz C, Spicer TP, Bannister TD, Tonge PJ, Airola MV, Scampavia L, Hannun YA, Rizzo RC, Haley JD. Coant N, et al. Among authors: choi ym. Bioorg Chem. 2023 Oct;139:106747. doi: 10.1016/j.bioorg.2023.106747. Epub 2023 Jul 27. Bioorg Chem. 2023. PMID: 37531819 Free PMC article.
The middle lipin domain adopts a membrane-binding dimeric protein fold.
Gu W, Gao S, Wang H, Fleming KD, Hoffmann RM, Yang JW, Patel NM, Choi YM, Burke JE, Reue K, Airola MV. Gu W, et al. Among authors: choi ym. Nat Commun. 2021 Aug 5;12(1):4718. doi: 10.1038/s41467-021-24929-5. Nat Commun. 2021. PMID: 34354069 Free PMC article.
Enantiomeric characterization and structure elucidation of Otamixaban.
Shen J, Yang J, Heyse W, Schweitzer H, Nagel N, Andert D, Zhu C, Morrison V, Nemeth GA, Chen TM, Zhao Z, Ayers TA, Choi YM. Shen J, et al. Among authors: choi ym. J Pharm Anal. 2014 Jun;4(3):197-204. doi: 10.1016/j.jpha.2013.10.001. Epub 2013 Nov 26. J Pharm Anal. 2014. PMID: 29403883 Free PMC article.
Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening.
Otsuka Y, Airola MV, Choi YM, Coant N, Snider J, Cariello C, Saied EM, Arenz C, Bannister T, Rahaim R Jr, Hannun YA, Shumate J, Scampavia L, Haley JD, Spicer TP. Otsuka Y, et al. Among authors: choi ym. SLAS Discov. 2021 Jan;26(1):113-121. doi: 10.1177/2472555220945283. Epub 2020 Jul 31. SLAS Discov. 2021. PMID: 32734807 Free PMC article.
X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase.
McLean LR, Zhang Y, Zaidi N, Bi X, Wang R, Dharanipragada R, Jurcak JG, Gillespy TA, Zhao Z, Musick KY, Choi YM, Barrague M, Peppard J, Smicker M, Duguid M, Parkar A, Fordham J, Kominos D. McLean LR, et al. Among authors: choi ym. Bioorg Med Chem Lett. 2012 May 1;22(9):3296-300. doi: 10.1016/j.bmcl.2012.03.016. Epub 2012 Mar 11. Bioorg Med Chem Lett. 2012. PMID: 22464456
11 results