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1,466 results

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Page 1
Did you mean can guide li (31,236 results)?
Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington's disease.
Yan S, Zheng X, Lin Y, Li C, Liu Z, Li J, Tu Z, Zhao Y, Huang C, Chen Y, Li J, Song X, Han B, Wang W, Liang W, Lai L, Li XJ, Li S. Yan S, et al. Nat Biomed Eng. 2023 May;7(5):629-646. doi: 10.1038/s41551-023-01007-3. Epub 2023 Feb 16. Nat Biomed Eng. 2023. PMID: 36797418
A single intracranial or intravenous injection of adeno-associated virus encoding for Cas9, a single-guide RNA targeting the HTT gene, and donor DNA containing the normal CAG repeat led to the depletion of mutant HTT in the animals and to substantial reductions in the dysr …
A single intracranial or intravenous injection of adeno-associated virus encoding for Cas9, a single-guide RNA targeting the HTT gene …
Correction of a genetic disease in mouse via use of CRISPR-Cas9.
Wu Y, Liang D, Wang Y, Bai M, Tang W, Bao S, Yan Z, Li D, Li J. Wu Y, et al. Cell Stem Cell. 2013 Dec 5;13(6):659-62. doi: 10.1016/j.stem.2013.10.016. Cell Stem Cell. 2013. PMID: 24315440 Free article.
Here we show that mice with a dominant mutation in Crygc gene that causes cataracts could be rescued by coinjection into zygotes of Cas9 mRNA and a single-guide RNA (sgRNA) targeting the mutant allele. Correction occurred via homology-directed repair (HDR) based on an exog …
Here we show that mice with a dominant mutation in Crygc gene that causes cataracts could be rescued by coinjection into zygotes of Cas9 mRN …
Improving prime editing with an endogenous small RNA-binding protein.
Yan J, Oyler-Castrillo P, Ravisankar P, Ward CC, Levesque S, Jing Y, Simpson D, Zhao A, Li H, Yan W, Goudy L, Schmidt R, Solley SC, Gilbert LA, Chan MM, Bauer DE, Marson A, Parsons LR, Adamson B. Yan J, et al. Nature. 2024 Apr;628(8008):639-647. doi: 10.1038/s41586-024-07259-6. Epub 2024 Apr 3. Nature. 2024. PMID: 38570691 Free PMC article.
Prime editing enables the precise modification of genomes through reverse transcription of template sequences appended to the 3' ends of CRISPR-Cas guide RNAs(1). To identify cellular determinants of prime editing, we developed scalable prime editing reporters and performe …
Prime editing enables the precise modification of genomes through reverse transcription of template sequences appended to the 3' ends of CRI …
2023 Chinese guideline for lipid management.
Li JJ, Zhao SP, Zhao D, Lu GP, Peng DQ, Liu J, Chen ZY, Guo YL, Wu NQ, Yan SK, Wang ZW, Gao RL. Li JJ, et al. Front Pharmacol. 2023 Aug 29;14:1190934. doi: 10.3389/fphar.2023.1190934. eCollection 2023. Front Pharmacol. 2023. PMID: 37711173 Free PMC article. Review.
The aim of these guidelines is to comprehensively improve the management of lipids and promote the prevention and treatment of ASCVD by guiding clinical practice....
The aim of these guidelines is to comprehensively improve the management of lipids and promote the prevention and treatment of ASCVD by g …
The use of PET/MRI in radiotherapy.
Yan Q, Yan X, Yang X, Li S, Song J. Yan Q, et al. Insights Imaging. 2024 Feb 27;15(1):63. doi: 10.1186/s13244-024-01627-6. Insights Imaging. 2024. PMID: 38411742 Free PMC article. Review.
Recent studies have demonstrated that PET/MRI provides unique advantages in the field of radiotherapy and has become invaluable in guiding precision radiotherapy techniques. This review discusses the rationale and clinical evidence supporting the use of PET/MRI for radiati …
Recent studies have demonstrated that PET/MRI provides unique advantages in the field of radiotherapy and has become invaluable in guidin …
2023 China Guidelines for Lipid Management.
Li JJ, Zhao SP, Zhao D, Lu GP, Peng DQ, Liu J, Chen ZY, Guo YL, Wu NQ, Yan SK, Wang ZW, Gao RL. Li JJ, et al. J Geriatr Cardiol. 2023 Sep 28;20(9):621-663. doi: 10.26599/1671-5411.2023.09.008. J Geriatr Cardiol. 2023. PMID: 37840633 Free PMC article.
The aim of these guidelines is to comprehensively improve the management of lipids and promote the prevention and treatment of ASCVD by guiding clinical practice....
The aim of these guidelines is to comprehensively improve the management of lipids and promote the prevention and treatment of ASCVD by g …
Ethical considerations of cellular immunotherapy for cancer.
Ren SS, Deng JW, Hong M, Ren YL, Fu HJ, Liu YN, Chen Z. Ren SS, et al. J Zhejiang Univ Sci B. 2019 Jan.;20(1):23-31. doi: 10.1631/jzus.B1800421. J Zhejiang Univ Sci B. 2019. PMID: 30614227 Free PMC article. Review.
Thus, studies should focus on proper adherence to basic ethical principles that can effectively guide and solve related clinical problems in the course of treatment, improve treatment effects, and protect the rights and interests of patients. ...
Thus, studies should focus on proper adherence to basic ethical principles that can effectively guide and solve related clinical prob …
MicroRNA: Another Pharmacological Avenue for Colorectal Cancer?
Wu X, Yan F, Wang L, Sun G, Liu J, Qu M, Wang Y, Li T. Wu X, et al. Front Cell Dev Biol. 2020 Sep 2;8:812. doi: 10.3389/fcell.2020.00812. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32984321 Free PMC article. Review.
Eventually, we discuss the potential directions and perspectives of miR. This article serves as a guide for further studies and implicate miR as a potent theranostic target for colorectal cancer....
Eventually, we discuss the potential directions and perspectives of miR. This article serves as a guide for further studies and impli …
Machine learning facilitating the rational design of nanozymes.
Li Y, Zhang R, Yan X, Fan K. Li Y, et al. J Mater Chem B. 2023 Jul 19;11(28):6466-6477. doi: 10.1039/d3tb00842h. J Mater Chem B. 2023. PMID: 37325942 Review.
However, their application is seriously restricted by the difficulty of rapidly creating high-performance nanozymes. The use of machine learning techniques to guide the rational design of nanozymes holds great promise to overcome this difficulty. ...
However, their application is seriously restricted by the difficulty of rapidly creating high-performance nanozymes. The use of machine lear …
Passive microfluidic devices for cell separation.
Zhang T, Di Carlo D, Lim CT, Zhou T, Tian G, Tang T, Shen AQ, Li W, Li M, Yang Y, Goda K, Yan R, Lei C, Hosokawa Y, Yalikun Y. Zhang T, et al. Biotechnol Adv. 2024 Mar-Apr;71:108317. doi: 10.1016/j.biotechadv.2024.108317. Epub 2024 Jan 12. Biotechnol Adv. 2024. PMID: 38220118 Review.
This work hopes to aid in facilitating the dissemination of knowledge in cell separation, guiding future research, and informing practical applications across diverse scientific disciplines....
This work hopes to aid in facilitating the dissemination of knowledge in cell separation, guiding future research, and informing prac …
1,466 results