Nuclear Export Inhibition for Radiosensitization: A Proof-of-Concept Phase 1 Clinical Trial of Selinexor (KPT-330) Combined With Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer

Affiliations

• ¹ Sheba Medical Center affiliated with Tel Aviv University, Ramat Gan, Israel; Department Radiation Oncology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address: yaacov.lawrence@sheba.health.gov.il.
• ² Sheba Medical Center affiliated with Tel Aviv University, Ramat Gan, Israel.
• ³ Shamir Medical Center affiliated with Tel Aviv University, Be'er Yaakov, Israel.
• ⁴ Laniado Hospital, Netanya, Israel.
• ⁵ Sheba Medical Center affiliated with Tel Aviv University, Ramat Gan, Israel; Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
• ⁶ Karyopharm Therapeutics, Newton, Massachusetts.
• ⁷ Sheba Medical Center affiliated with Tel Aviv University, Ramat Gan, Israel; Merlin Health, Boston, Massachusetts.