Abstract
Two new neolignans, schilancifolignans D and E (1 and 2), together with eight known ones, were isolated from the leaves and stems of Schisandra lancifolia. The structures of 1 and 2 were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were tested for their anti-HIV-1 activities and cytotoxicity. Both showed significant potential cytotoxic ability and weak anti-HIV-1 activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / isolation & purification*
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Anti-HIV Agents / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Drug Screening Assays, Antitumor
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HIV-1 / drug effects
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HL-60 Cells
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Humans
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KB Cells
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Lignans / chemistry
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Lignans / isolation & purification*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Schisandra / chemistry*
Substances
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Anti-HIV Agents
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Antineoplastic Agents, Phytogenic
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Lignans
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schilancifolignan D
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schilancifolignan E