Dracotanosides A-D, spermidine glycosides from Dracocephalum tanguticum: structure and amide rotational barrier

J Nat Prod. 2009 Jun;72(6):1006-10. doi: 10.1021/np900140s.

Abstract

Four new spermidine glycosides, dracotanosides A-D (1-4), have been isolated from Dracocephalum tanguticum. These molecules represent the first spermidine glycosides from this plant genus. The structures, including absolute configurations, were determined by spectroscopic and chemical methods. The amide bond rotational barrier of aglycone 1a was calculated by density functional theory (DFT) computation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology
  • Humans
  • K562 Cells
  • Lamiaceae / chemistry*
  • Molecular Structure
  • Spermidine / analogs & derivatives*
  • Spermidine / chemistry
  • Spermidine / isolation & purification*
  • Spermidine / pharmacology

Substances

  • Drugs, Chinese Herbal
  • Glycosides
  • Spermidine