Intravascular cardiac lipoproteinosis: extrarenal manifestation of lipoprotein glomerulopathy

Cardiovasc Pathol. 2019 Sep-Oct:42:6-9. doi: 10.1016/j.carpath.2019.04.006. Epub 2019 May 7.

Abstract

Intracapillary lipoprotein thrombi are a distinct histopathologic finding described in the setting of lipoprotein glomerulopathy. The disease is associated with mutations in the apolipoprotein E gene and responds well to lipid-lowering treatments. Lipoprotein glomerulopathy is thought to primarily affect the kidneys, and lipoprotein thrombi have never been described in any other organ. Herein we present the first recognized case with extrarenal manifestations in the form of intravascular cardiac lipoprotein deposition.

Keywords: Emboli; Genetic; Lipid.

Publication types

  • Case Reports

MeSH terms

  • Apolipoprotein E3 / genetics
  • Apolipoproteins E / genetics
  • Coronary Vessels / ultrastructure*
  • Genetic Predisposition to Disease
  • Heart Diseases / genetics
  • Heart Diseases / pathology*
  • Humans
  • Kidney Diseases / genetics
  • Kidney Diseases / pathology*
  • Lipoid Proteinosis of Urbach and Wiethe / genetics
  • Lipoid Proteinosis of Urbach and Wiethe / pathology*
  • Male
  • Middle Aged
  • Mutation
  • Phenotype

Substances

  • ApoE protein, human
  • Apolipoprotein E3
  • Apolipoproteins E

Supplementary concepts

  • Lipoprotein Glomerulopathy