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Year Number of Results
1990 1
1991 1
1993 2
1994 1
1996 1
2001 2
2002 2
2003 1
2005 1
2006 2
2007 3
2008 1
2009 4
2010 6
2011 2
2012 8
2013 6
2014 4
2015 5
2016 3
2017 5
2018 8
2019 8
2020 21
2021 11
2022 13
2023 9
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119 results

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Page 1
Autoantibodies against type I IFNs in patients with life-threatening COVID-19.
Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K, Philippot Q, Rosain J, Béziat V, Manry J, Shaw E, Haljasmägi L, Peterson P, Lorenzo L, Bizien L, Trouillet-Assant S, Dobbs K, de Jesus AA, Belot A, Kallaste A, Catherinot E, Tandjaoui-Lambiotte Y, Le Pen J, Kerner G, Bigio B, Seeleuthner Y, Yang R, Bolze A, Spaan AN, Delmonte OM, Abers MS, Aiuti A, Casari G, Lampasona V, Piemonti L, Ciceri F, Bilguvar K, Lifton RP, Vasse M, Smadja DM, Migaud M, Hadjadj J, Terrier B, Duffy D, Quintana-Murci L, van de Beek D, Roussel L, Vinh DC, Tangye SG, Haerynck F, Dalmau D, Martinez-Picado J, Brodin P, Nussenzweig MC, Boisson-Dupuis S, Rodríguez-Gallego C, Vogt G, Mogensen TH, Oler AJ, Gu J, Burbelo PD, Cohen JI, Biondi A, Bettini LR, D'Angio M, Bonfanti P, Rossignol P, Mayaux J, Rieux-Laucat F, Husebye ES, Fusco F, Ursini MV, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Castagnoli R, Montagna D, Licari A, Marseglia GL, Duval X, Ghosn J; HGID Lab; NIAID-USUHS Immune Response to COVID Group; COVID Clinicians; COVID-STORM Clinicians; Imagine COVID Group; French COVID Cohort Study Group; Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19… See abstract for full author list ➔ Bastard P, et al. Science. 2020 Oct 23;370(6515):eabd4585. doi: 10.1126/science.abd4585. Epub 2020 Sep 24. Science. 2020. PMID: 32972996 Free PMC article.
The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. ...
The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not …
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.
Zatreanu D, Robinson HMR, Alkhatib O, Boursier M, Finch H, Geo L, Grande D, Grinkevich V, Heald RA, Langdon S, Majithiya J, McWhirter C, Martin NMB, Moore S, Neves J, Rajendra E, Ranzani M, Schaedler T, Stockley M, Wiggins K, Brough R, Sridhar S, Gulati A, Shao N, Badder LM, Novo D, Knight EG, Marlow R, Haider S, Callen E, Hewitt G, Schimmel J, Prevo R, Alli C, Ferdinand A, Bell C, Blencowe P, Bot C, Calder M, Charles M, Curry J, Ekwuru T, Ewings K, Krajewski W, MacDonald E, McCarron H, Pang L, Pedder C, Rigoreau L, Swarbrick M, Wheatley E, Willis S, Wong AC, Nussenzweig A, Tijsterman M, Tutt A, Boulton SJ, Higgins GS, Pettitt SJ, Smith GCM, Lord CJ. Zatreanu D, et al. Nat Commun. 2021 Jun 17;12(1):3636. doi: 10.1038/s41467-021-23463-8. Nat Commun. 2021. PMID: 34140467 Free PMC article.
Genetic perturbation screening revealed that defects in the 53BP1/Shieldin complex, which cause PARP inhibitor resistance, result in in vitro and in vivo sensitivity to small molecule Polteta polymerase inhibitors. ...
Genetic perturbation screening revealed that defects in the 53BP1/Shieldin complex, which cause PARP inhibitor resistance, result in in v …
Loss of lamin-B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus.
Matias I, Diniz LP, Damico IV, Araujo APB, Neves LDS, Vargas G, Leite REP, Suemoto CK, Nitrini R, Jacob-Filho W, Grinberg LT, Hol EM, Middeldorp J, Gomes FCA. Matias I, et al. Aging Cell. 2022 Jan;21(1):e13521. doi: 10.1111/acel.13521. Epub 2021 Dec 10. Aging Cell. 2022. PMID: 34894056 Free PMC article.
Senescent cells exhibit a specific phenotype, which includes an altered nuclear morphology and transcriptomic changes. Astrocytes undergo senescence in vitro and in age-associated neurodegenerative diseases, but little is known about whether this process also occurs in phy …
Senescent cells exhibit a specific phenotype, which includes an altered nuclear morphology and transcriptomic changes. Astrocytes undergo se …
Intestinal Organoids-Current and Future Applications.
Meneses AMC, Schneeberger K, Kruitwagen HS, Penning LC, van Steenbeek FG, Burgener IA, Spee B. Meneses AMC, et al. Vet Sci. 2016 Oct 21;3(4):31. doi: 10.3390/vetsci3040031. Vet Sci. 2016. PMID: 29056739 Free PMC article. Review.
Recent technical advances in the stem cell field have enabled the in vitro generation of complex structures resembling whole organs termed organoids. ...
Recent technical advances in the stem cell field have enabled the in vitro generation of complex structures resembling whole organs t …
A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity.
Nuber S, Chung CY, Tardiff DF, Bechade PA, McCaffery TD, Shimanaka K, Choi J, Chang B, Raja W, Neves E, Burke C, Jiang X, Xu P, Khurana V, Dettmer U, Fanning S, Rhodes KJ, Selkoe DJ, Scannevin RH. Nuber S, et al. Neurotherapeutics. 2022 Apr;19(3):1018-1036. doi: 10.1007/s13311-022-01199-7. Epub 2022 Apr 20. Neurotherapeutics. 2022. PMID: 35445353 Free PMC article.
Here, we report the efficacy of YTX-7739 in reversing pathological alphaSyn phenotypes in various in vitro and in vivo PD models. In cell-based assays, YTX-7739 decreased alphaSyn-mediated neuronal death, reversed the abnormal membrane interaction of amplified E46K ("3K") …
Here, we report the efficacy of YTX-7739 in reversing pathological alphaSyn phenotypes in various in vitro and in vivo PD models. In …
In vitro activity of isavuconazole against clinically relevant Trichosporon species: a comparative evaluation of EUCAST broth microdilution and MIC Test Strip methods.
Francisco EC, Dieleman C, Hagen F, Colombo AL; Trichosporon Brazilian Network. Francisco EC, et al. J Antimicrob Chemother. 2023 Mar 2;78(3):817-822. doi: 10.1093/jac/dkad016. J Antimicrob Chemother. 2023. PMID: 36702754
METHODS: Antifungal susceptibility testing for isavuconazole, fluconazole, voriconazole and posaconazole was assessed by EUCAST E.DEF 7.3.2. MIC values of isavuconazole obtained by BMD after 48 h of incubation were compared with MTS MICs after 24 and 48 h of incubat …
METHODS: Antifungal susceptibility testing for isavuconazole, fluconazole, voriconazole and posaconazole was assessed by EUCAST E.DEF 7.3.2. …
Microphysiological systems to study tumor-stroma interactions in brain cancer.
Neves ER, Harley BAC, Pedron S. Neves ER, et al. Brain Res Bull. 2021 Sep;174:220-229. doi: 10.1016/j.brainresbull.2021.06.012. Epub 2021 Jun 21. Brain Res Bull. 2021. PMID: 34166771 Free PMC article. Review.
Therefore, increasing technological advances are focusing on in vitro and computational modeling to increase the throughput and predicting capabilities of preclinical systems. ...
Therefore, increasing technological advances are focusing on in vitro and computational modeling to increase the throughput and predi …
Déjà vu: Stimulating open drug discovery for SARS-CoV-2.
Ekins S, Mottin M, Ramos PRPS, Sousa BKP, Neves BJ, Foil DH, Zorn KM, Braga RC, Coffee M, Southan C, Puhl AC, Andrade CH. Ekins S, et al. Drug Discov Today. 2020 May;25(5):928-941. doi: 10.1016/j.drudis.2020.03.019. Epub 2020 Apr 19. Drug Discov Today. 2020. PMID: 32320852 Free PMC article. Review.
In the COVID-19 pandemic, despite being a new virus, there are already drugs suggested as active in in vitro assays that are being repurposed in clinical trials. Promising SARS-CoV-2 viral targets and computational approaches are described and discussed. ...
In the COVID-19 pandemic, despite being a new virus, there are already drugs suggested as active in in vitro assays that are being re …
Cyclodextrin and TiF4 Nanocomplex on Enamel Demineralization.
Vieira T, Alexandria AK, Amaral LH, Neves AA, Lopes RT, Cabral LM, Valença AMG, Maia LC. Vieira T, et al. Braz Dent J. 2020 Sep 4;31(4):423-430. doi: 10.1590/0103-6440202002531. Braz Dent J. 2020. PMID: 32901720 Free article.
The aim of this study was to assess the effect of a newly developed nanocomplex formed of hydroxypropyl-b-cyclodextrin and 1% titanium tetrafluoride (TiF4) after distinct complexation periods (12/72 h) on demineralization of bovine enamel in vitro. Enamel blocks (n= …
The aim of this study was to assess the effect of a newly developed nanocomplex formed of hydroxypropyl-b-cyclodextrin and 1% titanium tetra …
119 results