ADIPOR1 is essential for vision and its RPE expression is lost in the Mfrp(rd6) mouse.
Sluch VM, Banks A, Li H, Crowley MA, Davis V, Xiang C, Yang J, Demirs JT, Vrouvlianis J, Leehy B, Hanks S, Hyman AM, Aranda J, Chang B, Bigelow CE, Rice DS.
Sluch VM, et al.
Sci Rep. 2018 Sep 25;8(1):14339. doi: 10.1038/s41598-018-32579-9.
Sci Rep. 2018.
PMID: 30254279
Free PMC article.
A KO of AdipoR1 post-development either in photoreceptors or the retinal pigment epithelium (RPE) resulted in decreased expression of retinal proteins, establishing a role for ADIPOR1 in supporting vision in adulthood. Subsequent analysis of the Mfrp(rd6) mouse retina demo …
A KO of AdipoR1 post-development either in photoreceptors or the retinal pigment epithelium (RPE) resulted in decreased expression of retina …