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1964 1
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Page 1
Higher susceptibility of somatostatin 4 receptor gene-deleted mice to chronic stress-induced behavioral and neuroendocrine alterations.
Scheich B, Csekő K, Borbély É, Ábrahám I, Csernus V, Gaszner B, Helyes Z. Scheich B, et al. Neuroscience. 2017 Mar 27;346:320-336. doi: 10.1016/j.neuroscience.2017.01.039. Epub 2017 Feb 1. Neuroscience. 2017. PMID: 28161436
In Sstr4(+/+) mice, there was no behavioral response to the applied CVS paradigm. ...Adrenal weights increased and thymus weights decreased in both Sstr4(+/+) and Sstr4(-/-) mice demonstrating the effect of chronic stress. The relative adrenal weight of stressed kno …
In Sstr4(+/+) mice, there was no behavioral response to the applied CVS paradigm. ...Adrenal weights increased and thymus weights dec …
Inhibition of phosphatidylinositol 3-kinase α (PI3Kα) prevents heterotopic ossification.
Valer JA, Sánchez-de-Diego C, Gámez B, Mishina Y, Rosa JL, Ventura F. Valer JA, et al. EMBO Mol Med. 2019 Sep;11(9):e10567. doi: 10.15252/emmm.201910567. Epub 2019 Aug 2. EMBO Mol Med. 2019. PMID: 31373426 Free PMC article.
Here, we demonstrate the efficacy of BYL719, a PI3Kalpha inhibitor, in preventing HO in mice. We found that PI3Kalpha inhibitors reduce SMAD, AKT, and mTOR/S6K activities. ...Further, the efficacy of PI3Kalpha inhibitors was evaluated in transgenic mice expressing A …
Here, we demonstrate the efficacy of BYL719, a PI3Kalpha inhibitor, in preventing HO in mice. We found that PI3Kalpha inhibitors redu …
HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling.
Pedrazza L, Martinez-Martinez A, Sánchez-de-Diego C, Valer JA, Pimenta-Lopes C, Sala-Gaston J, Szpak M, Tyler-Smith C, Ventura F, Rosa JL. Pedrazza L, et al. Cell Death Dis. 2023 Jan 12;14(1):17. doi: 10.1038/s41419-023-05549-x. Cell Death Dis. 2023. PMID: 36635269 Free PMC article.
During this process, HERC1 deficiency increases the levels of C-RAF and of phosphorylated ERK and p38. The Herc1-knockout adult mice developed imbalanced bone homeostasis that presented as osteopenia in both sexes of the adult mice. By contrast, only young female kn …
During this process, HERC1 deficiency increases the levels of C-RAF and of phosphorylated ERK and p38. The Herc1-knockout adult mice …
NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression.
Sánchez-de-Diego C, Pedrazza L, Pimenta-Lopes C, Martinez-Martinez A, Dahdah N, Valer JA, Garcia-Roves P, Rosa JL, Ventura F. Sánchez-de-Diego C, et al. Redox Biol. 2021 Apr;40:101845. doi: 10.1016/j.redox.2020.101845. Epub 2020 Dec 24. Redox Biol. 2021. PMID: 33373776 Free PMC article.
Finally, treatment with dimethyl fumarate prevented the deleterious effects of ovariectomy in trabecular bone masses of mice and restored osteocytic gene expression. Altogether, we uncovered the role of NRF2 activity in osteocytes during the regulation of osteocyte gene ex …
Finally, treatment with dimethyl fumarate prevented the deleterious effects of ovariectomy in trabecular bone masses of mice and rest …
Glucose Restriction Promotes Osteocyte Specification by Activating a PGC-1α-Dependent Transcriptional Program.
Sánchez-de-Diego C, Artigas N, Pimenta-Lopes C, Valer JA, Torrejon B, Gama-Pérez P, Villena JA, Garcia-Roves PM, Rosa JL, Ventura F. Sánchez-de-Diego C, et al. iScience. 2019 May 31;15:79-94. doi: 10.1016/j.isci.2019.04.015. Epub 2019 Apr 12. iScience. 2019. PMID: 31039455 Free PMC article.
Finally, conditional ablation of both genes in osteoblasts and osteocytes generate osteopenia and reduce osteocytic gene expression in mice. Altogether, we uncovered a role for PGC-1 in the regulation of osteocyte gene expression....
Finally, conditional ablation of both genes in osteoblasts and osteocytes generate osteopenia and reduce osteocytic gene expression in mi …
Isolated Peptide from Spider Venom Modulates Dendritic Cells In Vitro: A Possible Application in Oncoimmunotherapy for Glioblastoma.
de Mato FC, Barreto N, Cordeiro G, Munhoz J, Bonfanti AP, da Rocha-E-Silva TAA, Sutti R, Cruz PBM, Sanches LR, Bombeiro AL, Chalbatani GM, Verinaud L, Rapôso C. de Mato FC, et al. Cells. 2023 Mar 27;12(7):1023. doi: 10.3390/cells12071023. Cells. 2023. PMID: 37048096 Free PMC article.
For this purpose, bone marrow precursors were collected from male C57BL6 mice, differentiated into DCs and treated with venom or PnV-isolated fractions (F1-molecules < 3 kDa, F2-3 to 10 kDa and F3->10 kDa), with or without costimulation with human GB lysate. ...
For this purpose, bone marrow precursors were collected from male C57BL6 mice, differentiated into DCs and treated with venom or PnV- …
[STUDY OF THE SEDATIVE ACTION OF VALERIAN].
ZBURZHINSKII VK. ZBURZHINSKII VK. Farmakol Toksikol. 1964 May-Jun;27:301-5. Farmakol Toksikol. 1964. PMID: 14242269 Russian. No abstract available.