A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers.
Whitfield JB, Schwantes-An TH, Darlay R, Aithal GP, Atkinson SR, Bataller R, Botwin G, Chalasani NP, Cordell HJ, Daly AK, Day CP, Eyer F, Foroud T, Gleeson D, Goldman D, Haber PS, Jacquet JM, Liang T, Liangpunsakul S, Masson S, Mathurin P, Moirand R, McQuillin A, Moreno C, Morgan MY, Mueller S, Müllhaupt B, Nagy LE, Nahon P, Nalpas B, Naveau S, Perney P, Pirmohamed M, Seitz HK, Soyka M, Stickel F, Thompson A, Thursz MR, Trépo E, Morgan TR, Seth D; GenomALC Consortium.
Whitfield JB, et al.
J Hepatol. 2022 Feb;76(2):275-282. doi: 10.1016/j.jhep.2021.10.005. Epub 2021 Oct 14.
J Hepatol. 2022.
PMID: 34656649
Free PMC article.
Patients with cirrhosis and HCC had significantly higher mean risk scores than patients with cirrhosis alone (0.76 0.06 vs. 0.61 0.02, p = 0.007). Score performance was not significantly enhanced by information on additional genetic risk variants, body mass index or coffee …
Patients with cirrhosis and HCC had significantly higher mean risk scores than patients with cirrhosis alone (0.76 0.06 vs. 0.61 0.02, p …