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Multi-segmental spine image registration supporting image-guided interventions of spinal metastases.
Hille G, Saalfeld S, Serowy S, Tönnies K. Hille G, et al. Comput Biol Med. 2018 Nov 1;102:16-20. doi: 10.1016/j.compbiomed.2018.09.003. Epub 2018 Sep 13. Comput Biol Med. 2018. PMID: 30236968
Additionally, intra- and inter-reader variability was determined, resulting in mean distances of corresponding landmark pairs of 1.05mm (MRI) and 1.03mm (flat-panel CT) for the intra-reader variability and 1.36mm and 1.28mm for the inter-reader variability, respectively. CONCLUSI …
Additionally, intra- and inter-reader variability was determined, resulting in mean distances of corresponding landmark pairs of 1.05mm (MRI …
Transformation of microbiology data into a standardised data representation using OpenEHR.
Wulff A, Baier C, Ballout S, Tute E, Sommer KK, Kaase M, Sargeant A, Drenkhahn C; Infection Control Study Group; Schlüter D, Marschollek M, Scheithauer S. Wulff A, et al. Sci Rep. 2021 May 18;11(1):10556. doi: 10.1038/s41598-021-89796-y. Sci Rep. 2021. PMID: 34006956 Free PMC article.
To allow application reusability across institutions, the various heterogeneous microbiology data representations needs to be transformed into standardised, unambiguous data models. In this work, we present a multi-centric standardisation approach by using openEHR as model …
To allow application reusability across institutions, the various heterogeneous microbiology data representations needs to be transformed in …
Fully automated deep learning-based localization and segmentation of the locus coeruleus in aging and Parkinson's disease using neuromelanin-sensitive MRI.
Dünnwald M, Ernst P, Düzel E, Tönnies K, Betts MJ, Oeltze-Jafra S. Dünnwald M, et al. Int J Comput Assist Radiol Surg. 2021 Dec;16(12):2129-2135. doi: 10.1007/s11548-021-02528-5. Epub 2021 Nov 19. Int J Comput Assist Radiol Surg. 2021. PMID: 34797512 Free PMC article.
METHODS: We propose a pipeline composed of several 3D-Unet-based convolutional neural networks for iterative multi-scale localization and multi-rater segmentation and non-deep learning-based components for automated biomarker extraction. ...
METHODS: We propose a pipeline composed of several 3D-Unet-based convolutional neural networks for iterative multi-scale localization …
Combining convolutional neural networks and star convex cuts for fast whole spine vertebra segmentation in MRI.
Rak M, Steffen J, Meyer A, Hansen C, Tönnies KD. Rak M, et al. Comput Methods Programs Biomed. 2019 Aug;177:47-56. doi: 10.1016/j.cmpb.2019.05.003. Epub 2019 May 16. Comput Methods Programs Biomed. 2019. PMID: 31319960
We tackle this problem by novel non-overlap constraints between neighboring patches based on so-called encoding swaps. The latter allow us to obtain a globally optimal multi-label segmentation of all vertebrae in polynomial time. RESULTS: We validated our approach on two d …
We tackle this problem by novel non-overlap constraints between neighboring patches based on so-called encoding swaps. The latter allow us t …
Health policy experts' perspectives on implementing mental health specialist video consultations in routine primary care - a qualitative interview study.
Tönnies J, Oeljeklaus L, Wensing M, Hartmann M, Friederich HC, Haun MW. Tönnies J, et al. BMC Health Serv Res. 2021 Jul 20;21(1):713. doi: 10.1186/s12913-021-06676-x. BMC Health Serv Res. 2021. PMID: 34284786 Free PMC article.
CONCLUSIONS: Health policy experts mostly consider mental health specialist video consultations as a promising way to overcome current challenges for the management of patients with mental disorders at the interface between primary and specialist care. To ensure sustained impleme …
CONCLUSIONS: Health policy experts mostly consider mental health specialist video consultations as a promising way to overcome current chall …
Joint deformable liver registration and bias field correction for MR-guided HDR brachytherapy.
Rak M, König T, Tönnies KD, Walke M, Ricke J, Wybranski C. Rak M, et al. Int J Comput Assist Radiol Surg. 2017 Dec;12(12):2169-2180. doi: 10.1007/s11548-017-1633-2. Epub 2017 Jul 6. Int J Comput Assist Radiol Surg. 2017. PMID: 28685419
METHODS: We propose a fast and robust two-step registration framework suitable for interventional settings: first, we utilize a multi-resolution rigid registration to correct for differences in patient positioning (rotation and translation). ...In contrast to existing pre- …
METHODS: We propose a fast and robust two-step registration framework suitable for interventional settings: first, we utilize a multi …
Dosage effect of zero to three functional LBR-genes in vivo and in vitro.
Gravemann S, Schnipper N, Meyer H, Vaya A, Nowaczyk MJ, Rajab A, Hofmann WK, Salewsky B, Tönnies H, Neitzel H, Stassen HH, Sperling K, Hoffmann K. Gravemann S, et al. Nucleus. 2010 Mar-Apr;1(2):179-89. doi: 10.4161/nucl.1.2.11113. Epub 2010 Jan 3. Nucleus. 2010. PMID: 21326950 Free PMC article.
We further show that LBR expression continually increases during granulopoiesis in vitro from human precursor cells with ovoid nuclei to multi-segmented neutrophil nuclei 11 days later, indicating relevance for regular human granulopoiesis. ...
We further show that LBR expression continually increases during granulopoiesis in vitro from human precursor cells with ovoid nuclei to …