The Research on the Treatment of Metastatic Skin Cutaneous Melanoma by Huanglian Jiedu Decoction Based on the Analysis of Immune Infiltration Analysis

Ding Li; Shi-Fang Li; Xiao-Yuan Li; Xiao-Wei Sun; Tian-Yue Sun; Guo-Jie Hu

doi:10.1155/2021/9952060

The Research on the Treatment of Metastatic Skin Cutaneous Melanoma by Huanglian Jiedu Decoction Based on the Analysis of Immune Infiltration Analysis

Evid Based Complement Alternat Med. 2021 Jun 21:2021:9952060. doi: 10.1155/2021/9952060. eCollection 2021.

Authors

Ding Li¹, Shi-Fang Li², Xiao-Yuan Li³, Xiao-Wei Sun³, Tian-Yue Sun¹, Guo-Jie Hu^{1

3}

Affiliations

¹ Department of Traditional Chinese Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 26600, China.
² Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 26600, China.
³ Basic Medical School, Medical College, Qingdao University, Qingdao, Shandong 26600, China.

Abstract

Objective: To explore the potential mechanism of Huanglian Jiedu Decoction (HJD) treatment and prevention of metastatic Cutaneous Melanoma (CM) occurrence and metastasis based on network pharmacological methods and immune infiltration analysis.

Methods: The GEO database was used to obtain metastatic CM disease targets, the TCMSP database and the HERB database were used to obtain HJD action targets, core genes were screened by protein interaction network, and the potential mechanism of HJD in the treatment of metastatic CM was explored by enrichment analysis, prognostic analysis and immune infiltration analysis.

Results: HJD treatment of metastatic CM involved 60 targets, enrichment analysis showed that HJD treatment of metastatic CM involved Chemokine signaling pathway, NF-kappa B signaling pathway, and Fluid shear stress and atherosclerosis, etc. Prognostic analysis revealed that HJD had a certain ability to improve the prognosis of metastatic CM patients. Immune infiltration analysis showed that HJD could inhibit the immune cell infiltration of metastatic CM patients by acting on related targets.

Conclusions: Our study identified the potential mechanism of HJD in the treatment of metastatic CM through network pharmacology, and revealed the mechanism of HJD in the prevention of Skin Cutaneous Melanoma metastasis through immune infiltration analysis and prognostic analysis.