Isocoumarins from American cockroach (Periplaneta americana) and their cytotoxic activities

Fitoterapia. 2014 Jun:95:115-20. doi: 10.1016/j.fitote.2014.03.004. Epub 2014 Mar 13.

Abstract

Four new isocoumarins (1-4), along with three known ones (5-7), were isolated from the 70% ethanol extract of the whole body of the traditional Chinese insect medicine, American cockroach (Periplaneta americana). The structures with absolute configurations of new compounds were elucidated by extensive spectroscopic methods in combination with X-ray diffraction experiment and CD analyses. Compounds 3-5 showed significant cytotoxic activities in HepG2 and MCF-7 cells with IC50 values in the ranges 6.41-23.91 μM and 6.67-39.07 μM, respectively.

Keywords: American cockroach; Cytotoxicity; Isocoumarin; Periplaneta americana.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Crystallography, X-Ray
  • Humans
  • Inhibitory Concentration 50
  • Isocoumarins / chemistry
  • Isocoumarins / isolation & purification
  • Isocoumarins / pharmacology*
  • Medicine, Chinese Traditional
  • Molecular Structure
  • Periplaneta / chemistry*

Substances

  • Isocoumarins