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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1924 1
1964 1
1965 1
1967 1
1969 3
1970 4
1971 8
1972 3
1973 2
1974 10
1975 18
1976 11
1977 25
1978 74
1979 68
1980 94
1981 94
1982 121
1983 144
1984 197
1985 207
1986 232
1987 260
1988 284
1989 360
1990 390
1991 436
1992 482
1993 514
1994 524
1995 565
1996 509
1997 581
1998 613
1999 618
2000 688
2001 650
2002 678
2003 779
2004 812
2005 952
2006 980
2007 1089
2008 1173
2009 1268
2010 1329
2011 1533
2012 1660
2013 1797
2014 1781
2015 1881
2016 1872
2017 1810
2018 1779
2019 1888
2020 1989
2021 2164
2022 2048
2023 1991
2024 854

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38,889 results

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Page 1
Efficient precise integration of large DNA sequences with 3'-overhang dsDNA donors using CRISPR/Cas9.
Han W, Li Z, Guo Y, He K, Li W, Xu C, Ge L, He M, Yin X, Zhou J, Li C, Yao D, Bao J, Liang H. Han W, et al. Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2221127120. doi: 10.1073/pnas.2221127120. Epub 2023 May 22. Proc Natl Acad Sci U S A. 2023. PMID: 37216515 Free PMC article.
However, the current approaches that allow precise integration of gene-sized large DNA fragments generally suffer from low efficiency and high cost. ...This newly designed LOCK approach based on homology-directed repair is a powerful tool suitable for gene-sized fra …
However, the current approaches that allow precise integration of gene-sized large DNA fragments generally suffer from low efficiency …
Optical Genome Mapping Enables Detection and Accurate Sizing of RFC1 Repeat Expansions.
Facchini S, Dominik N, Manini A, Efthymiou S, Currò R, Rugginini B, Vegezzi E, Quartesan I, Perrone B, Kutty SK, Galassi Deforie V, Schnekenberg RP, Abati E, Pichiecchio A, Valente EM, Tassorelli C, Reilly MM, Houlden H, Bugiardini E, Cortese A. Facchini S, et al. Biomolecules. 2023 Oct 19;13(10):1546. doi: 10.3390/biom13101546. Biomolecules. 2023. PMID: 37892228 Free PMC article.
The two methods are applied to 17 CANVAS patients' blood samples and resulting sizes compared, showing a good agreement. Further, long-read sequencing is used for two patients to investigate the agreement of sizes with either SB or OGM. Our study concludes that OGM …
The two methods are applied to 17 CANVAS patients' blood samples and resulting sizes compared, showing a good agreement. Further, lon …
I(8)Sb(10)Ge(36).
Kars M, Roisnel T, Dorcet V, Rebbah A, Otero-Diáz LC. Kars M, et al. Acta Crystallogr Sect E Struct Rep Online. 2010 May 19;66(Pt 6):i47. doi: 10.1107/S1600536810017496. Acta Crystallogr Sect E Struct Rep Online. 2010. PMID: 21579265 Free PMC article.
The structure is isotypic with the analogous clathrates-I. In this structure, the (Ge,Sb)(46) framework consists of statistically occupied Ge and Sb sites that atoms form bonds in a distorted tetra-hedral arrangement. They form polyhedra that are covalently bonded t …
The structure is isotypic with the analogous clathrates-I. In this structure, the (Ge,Sb)(46) framework consists of statistically occ …
Synthesis of Ge(1-x)Sn(x) nanoparticles under non-inert conditions.
Søgaard NB, Bondesgaard M, Bertelsen AD, Iversen BB, Julsgaard B. Søgaard NB, et al. Dalton Trans. 2022 Nov 21;51(45):17488-17495. doi: 10.1039/d2dt02739a. Dalton Trans. 2022. PMID: 36331388
The product formation is also investigated with in situ powder X-ray diffraction (PXRD) to study the effect of the reaction parameters in more detail, e.g. showing that the Sn-precursor catalyzes the reaction. The synthesized phase pure Ge(1-x)Sn(x) nanoparticles have Sn c …
The product formation is also investigated with in situ powder X-ray diffraction (PXRD) to study the effect of the reaction parameters in mo …
Microfluidics and the quantification of biomolecular interactions.
Otzen DE, Buell AK, Jensen H. Otzen DE, et al. Curr Opin Struct Biol. 2021 Oct;70:8-15. doi: 10.1016/j.sbi.2021.02.006. Epub 2021 Apr 5. Curr Opin Struct Biol. 2021. PMID: 33831785 Free article. Review.
Flow-induced dispersion analysis directly measures the spread of the analyte profile using Taylor dispersion analysis, whereas microfluidic diffusional sizing quantifies the transfer of analyte from one phase to another. Species of sizes between 0.5 and 1000 nm can …
Flow-induced dispersion analysis directly measures the spread of the analyte profile using Taylor dispersion analysis, whereas microfluidic …
I(8)As(21)Ge(25).
Ayouz K, Kars M, Rebbah A, Rebbah H. Ayouz K, et al. Acta Crystallogr Sect E Struct Rep Online. 2009 Feb 18;65(Pt 3):i15. doi: 10.1107/S1600536809004991. Acta Crystallogr Sect E Struct Rep Online. 2009. PMID: 21582033 Free PMC article.
In this structure, the statistically occupied clathrand atoms (As,Ge)(46) form bonds in a distorted tetra-hedral coordination and their arrangement can define two polyhedra of different sizes; one is an (As,Ge)(20) penta-gonal dodeca-hedron, and the other is …
In this structure, the statistically occupied clathrand atoms (As,Ge)(46) form bonds in a distorted tetra-hedral coordination and the …
Genome size evolution: sizing mammalian genomes.
Redi CA, Capanna E. Redi CA, et al. Cytogenet Genome Res. 2012;137(2-4):97-112. doi: 10.1159/000338820. Epub 2012 May 23. Cytogenet Genome Res. 2012. PMID: 22627028 Review.
This value appears compatible with the average values calculated for the high systematic levels of the extant Monotremata (2.97 pg) and Marsupialia (4.07 pg), suggesting invasion of mobile DNA elements concurrently with the separation of the older clades of Afrotheria (5.5 pg) an …
This value appears compatible with the average values calculated for the high systematic levels of the extant Monotremata (2.97 pg) and Mars …
Sizing, stabilising, and cloning repeat-expansions for gene targeting constructs.
Nair RR, Tibbit C, Thompson D, McLeod R, Nakhuda A, Simon MM, Baloh RH, Fisher EMC, Isaacs AM, Cunningham TJ. Nair RR, et al. Methods. 2021 Jul;191:15-22. doi: 10.1016/j.ymeth.2020.07.007. Epub 2020 Jul 25. Methods. 2021. PMID: 32721467 Free PMC article.
Here, we report our efforts to clone a large hexanucleotide repeat in the C9orf72 gene, originating from within a BAC construct, derived from a C9orf72-ALS patient. We provide detailed methods for efficient repeat sizing and growth conditions in bacteria to facilitate repe …
Here, we report our efforts to clone a large hexanucleotide repeat in the C9orf72 gene, originating from within a BAC construct, derived fro …
38,889 results
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