Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 1
1993 1
2001 2
2002 1
2004 1
2005 2
2006 5
2007 3
2008 3
2009 1
2010 3
2011 4
2012 6
2013 9
2014 6
2015 4
2016 6
2017 6
2018 12
2019 13
2020 7
2021 11
2022 21
2023 15
2024 15

Text availability

Article attribute

Article type

Publication date

Search Results

141 results

Results by year

Filters applied: . Clear all
Page 1
Pharmacological profile of asundexian, a novel, orally bioavailable inhibitor of factor XIa.
Heitmeier S, Visser M, Tersteegen A, Dietze-Torres J, Glunz J, Gerdes C, Laux V, Stampfuss J, Roehrig S. Heitmeier S, et al. J Thromb Haemost. 2022 Jun;20(6):1400-1411. doi: 10.1111/jth.15700. Epub 2022 Mar 25. J Thromb Haemost. 2022. PMID: 35289054 Free PMC article.
Antithrombotic effects were determined in FeCl(2) - and arterio-venous (AV) shunt models. Asundexian was administered intravenously or orally, before or during thrombus formation, and with or without antiplatelet drugs (aspirin and ticagrelor). ...In the FeCl(2) -injury mo …
Antithrombotic effects were determined in FeCl(2) - and arterio-venous (AV) shunt models. Asundexian was administered intravenously o …
Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis.
Xu P, Chen C, Zhang Y, Dzieciatkowska M, Brown BC, Zhang W, Xie T, Abdulmalik O, Song A, Tong C, Qi H, Roach R, Kellems RE, D'Alessandro A, Xia Y. Xu P, et al. Cell Metab. 2022 Feb 1;34(2):299-316.e6. doi: 10.1016/j.cmet.2021.12.019. Cell Metab. 2022. PMID: 35108516 Free PMC article.
Here, we report that erythrocyte transglutminase-2 (eTG2)-mediated PTM is essential to trigger O(2) delivery by promoting bisphosphoglycerate mutase proteostasis and the Rapoport-Luebering glycolytic shunt for adaptation to hypoxia, in healthy humans ascending to high alti …
Here, we report that erythrocyte transglutminase-2 (eTG2)-mediated PTM is essential to trigger O(2) delivery by promoting bisphosphoglycerat …
Concurrent large spontaneous portosystemic shunt embolization for the prevention of overt hepatic encephalopathy after TIPS: A randomized controlled trial.
Lv Y, Chen H, Luo B, Bai W, Li K, Wang Z, Xia D, Guo W, Wang Q, Li X, Yuan J, Cai H, Xia J, Yin Z, Fan D, Han G. Lv Y, et al. Hepatology. 2022 Sep;76(3):676-688. doi: 10.1002/hep.32453. Epub 2022 Apr 15. Hepatology. 2022. PMID: 35266571 Clinical Trial.
BACKGROUND AND AIMS: Large spontaneous portosystemic shunt (SPSS) is associated with increased risk of HE in patients undergoing transjugular intrahepatic portosystemic shunt (TIPS). ...The 2-year incidence of recurrent bleeding (TIPS+E vs. TIPS, 15.4% vs. 25.1%; p …
BACKGROUND AND AIMS: Large spontaneous portosystemic shunt (SPSS) is associated with increased risk of HE in patients undergoing tran …
DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER.
Rong S, Xia M, Vale G, Wang S, Kim CW, Li S, McDonald JG, Radhakrishnan A, Horton JD. Rong S, et al. Cell Metab. 2024 Mar 5;36(3):617-629.e7. doi: 10.1016/j.cmet.2024.01.011. Epub 2024 Feb 9. Cell Metab. 2024. PMID: 38340721 Free PMC article.
ER enrichment with PE blocked SREBP-1 cleavage independent of Insigs, which are ER proteins that normally retain SREBPs in the ER. Thus, inhibition of DGAT2 shunted diacylglycerol into phospholipid synthesis, increasing the PE content of the ER, resulting in reduced SREBP- …
ER enrichment with PE blocked SREBP-1 cleavage independent of Insigs, which are ER proteins that normally retain SREBPs in the ER. Thus, inh …
Erythrocyte Metabolic Reprogramming by Sphingosine 1-Phosphate in Chronic Kidney Disease and Therapies.
Xie T, Chen C, Peng Z, Brown BC, Reisz JA, Xu P, Zhou Z, Song A, Zhang Y, Bogdanov MV, Kellems RE, D'Alessandro A, Zhang W, Xia Y. Xie T, et al. Circ Res. 2020 Jul 17;127(3):360-375. doi: 10.1161/CIRCRESAHA.119.316298. Epub 2020 Apr 14. Circ Res. 2020. PMID: 32284030 Free article.
Untargeted metabolomics profiling and in vivo U-(13)C(6) isotopically labeled glucose flux analysis revealed that SphK1 is required for channeling glucose metabolism toward glycolysis versus pentose phosphate pathway, resulting in enhanced erythroid-specific Rapoport-Luebering …
Untargeted metabolomics profiling and in vivo U-(13)C(6) isotopically labeled glucose flux analysis revealed that SphK1 is required for chan …
MAP3K1 regulates female reproductive tract development.
Kimura E, Mongan M, Xiao B, Christianto A, Wang J, Carreira VS, Bolon B, Zhang X, Burns KA, Biesiada J, Medvedovic M, Puga A, Xia Y. Kimura E, et al. Dis Model Mech. 2024 Mar 1;17(3):dmm050669. doi: 10.1242/dmm.050669. Epub 2024 Mar 28. Dis Model Mech. 2024. PMID: 38501211 Free PMC article.
MAP3K1 kinase domain-deficient female mice exhibited an imperforate vagina, labor failure and infertility. These defects corresponded with shunted Mullerian ducts (MDs), the embryonic precursors of FRT, that manifested as a contorted caudal vagina and abrogated vaginal-uro …
MAP3K1 kinase domain-deficient female mice exhibited an imperforate vagina, labor failure and infertility. These defects corresponded with …
Transjugular intrahepatic portosystemic shunt with or without gastro-oesophageal variceal embolisation for the prevention of variceal rebleeding: a randomised controlled trial.
Lv Y, Chen H, Luo B, Bai W, Li K, Wang Z, Xia D, Guo W, Wang Q, Li X, Yuan J, Cai H, Xia J, Yin Z, Fan D, Han G. Lv Y, et al. Lancet Gastroenterol Hepatol. 2022 Aug;7(8):736-746. doi: 10.1016/S2468-1253(22)00087-5. Epub 2022 May 17. Lancet Gastroenterol Hepatol. 2022. PMID: 35588750 Clinical Trial.
BACKGROUND: The role of variceal embolisation at the time of transjugular intrahepatic portosystemic shunt (TIPS) creation for the prevention of gastro-oesophageal variceal rebleeding remains controversial. ...
BACKGROUND: The role of variceal embolisation at the time of transjugular intrahepatic portosystemic shunt (TIPS) creation for the pr …
Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions.
Xu G, Liu Z, Wang X, Lu T, DesJarlais RL, Thieu T, Zhang J, Devine ZH, Du F, Li Q, Milligan CM, Shaffer P, Cedervall PE, Spurlino JC, Stratton CF, Pietrak B, Szewczuk LM, Wong V, Steele RA, Bruinzeel W, Chintala M, Silva J, Gaul MD, Macielag MJ, Nargund R. Xu G, et al. J Med Chem. 2022 Aug 11;65(15):10419-10440. doi: 10.1021/acs.jmedchem.2c00442. Epub 2022 Jul 21. J Med Chem. 2022. PMID: 35862732
This compound demonstrated oral bioavailability in preclinical species (rat 36.4%, dog 80.5%, and monkey 43.0%) and displayed a dose-dependent antithrombotic effect in a rabbit arteriovenous shunt model of thrombosis....
This compound demonstrated oral bioavailability in preclinical species (rat 36.4%, dog 80.5%, and monkey 43.0%) and displayed a dose-depende …
Glutamine Metabolism in Macrophages: A Novel Target for Obesity/Type 2 Diabetes.
Ren W, Xia Y, Chen S, Wu G, Bazer FW, Zhou B, Tan B, Zhu G, Deng J, Yin Y. Ren W, et al. Adv Nutr. 2019 Mar 1;10(2):321-330. doi: 10.1093/advances/nmy084. Adv Nutr. 2019. PMID: 30753258 Free PMC article. Review.
Glutamine (the most abundant amino acid in the plasma of humans and many other mammals including rats) is effective in inducing polarization of M2 macrophages through the glutamine-UDP-N-acetylglucosamine pathway and alpha-ketoglutarate produced via glutaminolysis, whereas succin …
Glutamine (the most abundant amino acid in the plasma of humans and many other mammals including rats) is effective in inducing polarization …
141 results