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Year | Number of Results |
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2014 | 1 |
2015 | 2 |
2017 | 1 |
2024 | 0 |
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Page 1
Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists.
Bioorg Med Chem Lett. 2014 Sep 1;24(17):4332-5. doi: 10.1016/j.bmcl.2014.06.071. Epub 2014 Jul 3.
Bioorg Med Chem Lett. 2014.
PMID: 25088191
Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series.
Han S, Narayanan S, Kim SH, Calderon I, Zhu X, Kawasaki A, Yue D, Lehmann J, Wong A, Buzard DJ, Semple G, Carroll C, Chu ZL, Al-Sharmma H, Shu HH, Tung SF, Unett DJ, Behan DP, Yoon WH, Morgan M, Usmani KA, Chen C, Sadeque A, Leonard JN, Jones RM.
Han S, et al. Among authors: shu hh.
Bioorg Med Chem Lett. 2015 Aug 1;25(15):3034-8. doi: 10.1016/j.bmcl.2015.04.102. Epub 2015 May 23.
Bioorg Med Chem Lett. 2015.
PMID: 26048791
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Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.
Tran TA, Kramer B, Shin YJ, Vallar P, Boatman PD, Zou N, Sage CR, Gharbaoui T, Krishnan A, Pal B, Shakya SR, Garrido Montalban A, Adams JW, Ramirez J, Behan DP, Shifrina A, Blackburn A, Leakakos T, Shi Y, Morgan M, Sadeque A, Chen W, Unett DJ, Gaidarov I, Chen X, Chang S, Shu HH, Tung SF, Semple G.
Tran TA, et al. Among authors: shu hh.
J Med Chem. 2017 Feb 9;60(3):913-927. doi: 10.1021/acs.jmedchem.6b00871. Epub 2017 Jan 19.
J Med Chem. 2017.
PMID: 28072531
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Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat.
Tran TA, Shin YJ, Kramer B, Choi J, Zou N, Vallar P, Martens P, Boatman PD, Adams JW, Ramirez J, Shi Y, Morgan M, Unett DJ, Chang S, Shu HH, Tung SF, Semple G.
Tran TA, et al. Among authors: shu hh.
Bioorg Med Chem Lett. 2015 Mar 1;25(5):1030-5. doi: 10.1016/j.bmcl.2015.01.024. Epub 2015 Jan 22.
Bioorg Med Chem Lett. 2015.
PMID: 25666818
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