Improved synthesis of 3-(dialkylaminomethyl)-indole in acetic acid aqueous solution under ultrasound irradiation

Ji-Tai Li; Shao-Feng Sun; Ming-Xuan Sun

doi:10.1016/j.ultsonch.2010.05.010

Improved synthesis of 3-(dialkylaminomethyl)-indole in acetic acid aqueous solution under ultrasound irradiation

Ultrason Sonochem. 2011 Jan;18(1):42-4. doi: 10.1016/j.ultsonch.2010.05.010. Epub 2010 Jun 2.

Authors

Ji-Tai Li¹, Shao-Feng Sun, Ming-Xuan Sun

Affiliation

¹ College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, Key Laboratory of Medical Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, PR China. lijitai@hbu.cn

PMID: 20646952
DOI: 10.1016/j.ultsonch.2010.05.010

Abstract

Synthesis of Mannich bases related to gramine via Mannich reaction of secondary amine, formaldehyde and indole or N-methylindole can be carried out in 69-98% yields in acetic acid aqueous solution at 35°C under ultrasound irradiation. Compared with the method using stirring, the present procedure provided several advantages such as milder conditions, shorter reaction time and higher yield.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetates / chemistry*
Amines / chemistry
Formaldehyde / chemistry
Indoles / chemical synthesis*
Indoles / chemistry
Solutions
Ultrasonics*
Water / chemistry

Substances

Acetates
Amines
Indoles
Solutions
Water
Formaldehyde