68Ga-DOTATATE Avid Metastatic Vertebral Renal Cell Carcinoma in the Setting of von Hippel-Lindau Syndrome

Mayank Patel; Abhishek Jha; Tatjana Antic; Sarah M Nielsen; Jane E Churpek; Alexander Ling; Karel Pacak

doi:10.1007/s13139-022-00761-7

⁶⁸Ga-DOTATATE Avid Metastatic Vertebral Renal Cell Carcinoma in the Setting of von Hippel-Lindau Syndrome

Nucl Med Mol Imaging. 2022 Oct;56(5):259-262. doi: 10.1007/s13139-022-00761-7. Epub 2022 Jul 27.

Authors

Mayank Patel¹, Abhishek Jha¹, Tatjana Antic², Sarah M Nielsen^{3

4}, Jane E Churpek^{4

5}, Alexander Ling⁶, Karel Pacak¹

Affiliations

¹ Section on Medical Neuroendocrinology, Developmental Endocrine Oncology and Genetics Affinity Group, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Dr., MSC-1109, Bldg. 10, CRC, Room 1E-3140, Bethesda, MD 20892-1109 USA.
² Department of Pathology, University of Chicago Medical Center, Chicago, IL USA.
³ Invitae, Medical Affairs, San Francisco, CA USA.
⁴ Department of Medicine, Section of Hematology/Oncology and Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL USA.
⁵ Department of Medicine, Division of Hematology, Oncology, and Palliative Care & Carbone Cancer Center, The University of Wisconsin-Madison, Madison, WI USA.
⁶ Department of Radiology, Clinical Center, NIH, Bethesda, MD USA.

Abstract

Although rare, a metastatic renal cell carcinoma could present with ⁶⁸Ga-DOTATATE avidity. A 66-year-old man with von Hippel-Lindau syndrome (VHL) presented with ⁶⁸Ga-DOTATATE uptake in the pancreatic head, splenic hilar region, and multiple osseous sites, including the right lateral portion of the T9 vertebrae. Biopsy of the T9 lesion confirmed metastatic renal cell carcinoma. Various VHL-associated cancers may display ⁶⁸Ga-DOTATATE avidity, which can change and guide clinical decisions for the patient.

Keywords: 68Ga-DOTATATE; Paraganglioma; Pheochromocytoma; Renal cell carcinoma; Somatostatin receptors; von Hippel-Lindau.

Grants and funding

Z01 HD008735/ImNIH/Intramural NIH HHS/United States