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Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19.
Hammond J, Leister-Tebbe H, Gardner A, Abreu P, Bao W, Wisemandle W, Baniecki M, Hendrick VM, Damle B, Simón-Campos A, Pypstra R, Rusnak JM; EPIC-HR Investigators. Hammond J, et al. N Engl J Med. 2022 Apr 14;386(15):1397-1408. doi: 10.1056/NEJMoa2118542. Epub 2022 Feb 16. N Engl J Med. 2022. PMID: 35172054 Free PMC article. Clinical Trial.
BACKGROUND: Nirmatrelvir is an orally administered severe acute respiratory syndrome coronavirus 2 main protease (M(pro)) inhibitor with potent pan-human-coronavirus activity in vitro. METHODS: We conducted a phase 2-3 double-blind, randomized, controlled trial in which sy …
BACKGROUND: Nirmatrelvir is an orally administered severe acute respiratory syndrome coronavirus 2 main protease (M(pro)) inhibitor with pot …
A new insight into the treatment of diabetes by means of pan PPAR agonists.
Chandra A, Kaur P, Sahu SK, Mittal A. Chandra A, et al. Chem Biol Drug Des. 2022 Dec;100(6):947-967. doi: 10.1111/cbdd.14020. Epub 2022 Jan 17. Chem Biol Drug Des. 2022. PMID: 34990085 Review.
Type 2 diabetes constitutes about 90% of total diabetes cases. Pan PPAR ligands could very well pave the foundation for a new class of agents, that can act on all 3 PPAR receptors, and produce better effects in general, than the individual receptor-acting ligands or dual c …
Type 2 diabetes constitutes about 90% of total diabetes cases. Pan PPAR ligands could very well pave the foundation for a new class o …
Exploring Pan-Genomes: An Overview of Resources and Tools for Unraveling Structure, Function, and Evolution of Crop Genes and Genomes.
Naithani S, Deng CH, Sahu SK, Jaiswal P. Naithani S, et al. Biomolecules. 2023 Sep 17;13(9):1403. doi: 10.3390/biom13091403. Biomolecules. 2023. PMID: 37759803 Free PMC article. Review.
Here, we summarize the tools used for pan-genome assembly and annotations, web-portals hosting plant pan-genomes, etc. Furthermore, we highlight a few discoveries made in crops using the pan-genomic approach and future potential of this emerging field of stud …
Here, we summarize the tools used for pan-genome assembly and annotations, web-portals hosting plant pan-genomes, etc. Further …
Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma.
Chen X, Li Y, Zhu F, Xu X, Estrella B, Pazos MA 2nd, McGuire JT, Karagiannis D, Sahu V, Mustafokulov M, Scuoppo C, Sánchez-Rivera FJ, Soto-Feliciano YM, Pasqualucci L, Ciccia A, Amengual JE, Lu C. Chen X, et al. Nat Commun. 2023 Jul 17;14(1):4259. doi: 10.1038/s41467-023-39990-5. Nat Commun. 2023. PMID: 37460547 Free PMC article.
Here we perform co-dependency mapping of genes using CRISPR-Cas9-mediated fitness screens in pan-cancer cell lines to quantify gene-gene functional relationships. ...
Here we perform co-dependency mapping of genes using CRISPR-Cas9-mediated fitness screens in pan-cancer cell lines to quantify gene-g …
MYC regulates a pan-cancer network of co-expressed oncogenic splicing factors.
Urbanski L, Brugiolo M, Park S, Angarola BL, Leclair NK, Yurieva M, Palmer P, Sahu SK, Anczuków O. Urbanski L, et al. Cell Rep. 2022 Nov 22;41(8):111704. doi: 10.1016/j.celrep.2022.111704. Cell Rep. 2022. PMID: 36417849 Free PMC article.
In mammary cell models, MYC activation leads to co-upregulation of pan-cancer module SFs and to changes in >4,000 splicing events. ...Finally, we uncover a MYC-activity pan-cancer splicing signature correlating with survival across tumor types. ...
In mammary cell models, MYC activation leads to co-upregulation of pan-cancer module SFs and to changes in >4,000 splicing events. …
Low-dose atropine 0.01% for the treatment of childhood myopia: a pan-India multicentric retrospective study.
Saxena R, Gupta V, Dhiman R, Joseph E, Agarkar S, Neena R, Magdalene D, Jethani J, Ganesh SC, Patil M, Gogri P, Gadaginamath S, Sen P, Sukhija J, Mishra D, Matalia JH, Sahu A, Kapoor S, Nishanth S, Chaurasia S, Pawar N, Deori N, Sivaraman V, Bordoloi A, Tibrewal S, Singh D, Prasad P, Phuljhele S, Sharma N. Saxena R, et al. Br J Ophthalmol. 2024 Mar 20;108(4):588-592. doi: 10.1136/bjo-2023-324450. Br J Ophthalmol. 2024. PMID: 38290805
Vaccines against candidiasis: Status, challenges and emerging opportunity.
Sahu SR, Bose S, Singh M, Kumari P, Dutta A, Utkalaja BG, Patel SK, Acharya N. Sahu SR, et al. Front Cell Infect Microbiol. 2022 Aug 18;12:1002406. doi: 10.3389/fcimb.2022.1002406. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36061876 Free PMC article. Review.
In this minireview, we enumerate various concerted efforts made till date towards the development of anti-Candida vaccines, an option with pan-fugal vaccine, vaccines in the clinical trial, challenges, and future opportunities....
In this minireview, we enumerate various concerted efforts made till date towards the development of anti-Candida vaccines, an option with …
116 results