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Adjuvant Pembrolizumab after Nephrectomy in Renal-Cell Carcinoma.
Choueiri TK, Tomczak P, Park SH, Venugopal B, Ferguson T, Chang YH, Hajek J, Symeonides SN, Lee JL, Sarwar N, Thiery-Vuillemin A, Gross-Goupil M, Mahave M, Haas NB, Sawrycki P, Gurney H, Chevreau C, Melichar B, Kopyltsov E, Alva A, Burke JM, Doshi G, Topart D, Oudard S, Hammers H, Kitamura H, Bedke J, Perini RF, Zhang P, Imai K, Willemann-Rogerio J, Quinn DI, Powles T; KEYNOTE-564 Investigators. Choueiri TK, et al. N Engl J Med. 2021 Aug 19;385(8):683-694. doi: 10.1056/NEJMoa2106391. N Engl J Med. 2021. PMID: 34407342 Free article. Clinical Trial.
Cabozantinib plus Nivolumab and Ipilimumab in Renal-Cell Carcinoma.
Choueiri TK, Powles T, Albiges L, Burotto M, Szczylik C, Zurawski B, Yanez Ruiz E, Maruzzo M, Suarez Zaizar A, Fein LE, Schutz FA, Heng DYC, Wang F, Mataveli F, Chang YL, van Kooten Losio M, Suarez C, Motzer RJ; COSMIC-313 Investigators. Choueiri TK, et al. N Engl J Med. 2023 May 11;388(19):1767-1778. doi: 10.1056/NEJMoa2212851. N Engl J Med. 2023. PMID: 37163623 Free PMC article. Clinical Trial.
Pembrolizumab versus placebo as post-nephrectomy adjuvant therapy for clear cell renal cell carcinoma (KEYNOTE-564): 30-month follow-up analysis of a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.
Powles T, Tomczak P, Park SH, Venugopal B, Ferguson T, Symeonides SN, Hajek J, Gurney H, Chang YH, Lee JL, Sarwar N, Thiery-Vuillemin A, Gross-Goupil M, Mahave M, Haas NB, Sawrycki P, Burgents JE, Xu L, Imai K, Quinn DI, Choueiri TK; KEYNOTE-564 Investigators. Powles T, et al. Lancet Oncol. 2022 Sep;23(9):1133-1144. doi: 10.1016/S1470-2045(22)00487-9. Lancet Oncol. 2022. PMID: 36055304 Free article. Clinical Trial.
Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma.
Choueiri TK, Tomczak P, Park SH, Venugopal B, Ferguson T, Symeonides SN, Hajek J, Chang YH, Lee JL, Sarwar N, Haas NB, Gurney H, Sawrycki P, Mahave M, Gross-Goupil M, Zhang T, Burke JM, Doshi G, Melichar B, Kopyltsov E, Alva A, Oudard S, Topart D, Hammers H, Kitamura H, McDermott DF, Silva A, Winquist E, Cornell J, Elfiky A, Burgents JE, Perini RF, Powles T; KEYNOTE-564 Investigators. Choueiri TK, et al. N Engl J Med. 2024 Apr 18;390(15):1359-1371. doi: 10.1056/NEJMoa2312695. N Engl J Med. 2024. PMID: 38631003 Clinical Trial.
Brown spider (Loxosceles genus) venom toxins: Evaluation of biological conservation by immune cross-reactivity.
Buch DR, Souza FN, Meissner GO, Morgon AM, Gremski LH, Ferrer VP, Trevisan-Silva D, Matsubara FH, Boia-Ferreira M, Sade YB, Chaves-Moreira D, Gremski W, Veiga SS, Chaim OM, Senff-Ribeiro A. Buch DR, et al. Toxicon. 2015 Dec 15;108:154-66. doi: 10.1016/j.toxicon.2015.09.041. Epub 2015 Oct 22. Toxicon. 2015. PMID: 26474948
Our aim was to improve our knowledge, regarding the immunological relationship among toxins from the most epidemiologic important species in Brazil (Loxosceles intermedia, Loxosceles gaucho and Loxosceles laeta). Immunoassays using spider venoms and L. intermedia recombina …
Our aim was to improve our knowledge, regarding the immunological relationship among toxins from the most epidemiologic important species in …
Global COVID-19 lockdown highlights humans as both threats and custodians of the environment.
Bates AE, Primack RB, Biggar BS, Bird TJ, Clinton ME, Command RJ, Richards C, Shellard M, Geraldi NR, Vergara V, Acevedo-Charry O, Colón-Piñeiro Z, Ocampo D, Ocampo-Peñuela N, Sánchez-Clavijo LM, Adamescu CM, Cheval S, Racoviceanu T, Adams MD, Kalisa E, Kuuire VZ, Aditya V, Anderwald P, Wiesmann S, Wipf S, Badihi G, Henderson MG, Loetscher H, Baerenfaller K, Benedetti-Cecchi L, Bulleri F, Bertocci I, Maggi E, Rindi L, Ravaglioli C, Boerder K, Bonnel J, Mathias D, Archambault P, Chauvaud L, Braun CD, Thorrold SR, Brownscombe JW, Midwood JD, Boston CM, Brooks JL, Cooke SJ, China V, Roll U, Belmaker J, Zvuloni A, Coll M, Ortega M, Connors B, Lacko L, Jayathilake DRM, Costello MJ, Crimmins TM, Barnett L, Denny EG, Gerst KL, Marsh RL, Posthumus EE, Rodriguez R, Rosemartin A, Schaffer SN, Switzer JR, Wong K, Cunningham SJ, Sumasgutner P, Amar A, Thomson RL, Stofberg M, Hofmeyr S, Suri J, Stuart-Smith RD, Day PB, Edgar GJ, Cooper AT, De Leo FC, Garner G, Des Brisay PG, Schrimpf MB, Koper N, Diamond MS, Dwyer RG, Baker CJ, Franklin CE, Efrat R, Berger-Tal O, Hatzofe O, Eguíluz VM, Rodríguez JP, Fernández-Gracia J, Elustondo D, Calatayud V, English PA, Archer SK, Dudas SE, Haggarty DR, Gal… See abstract for full author list ➔ Bates AE, et al. Biol Conserv. 2021 Nov;263:109175. doi: 10.1016/j.biocon.2021.109175. Epub 2021 May 20. Biol Conserv. 2021. PMID: 34035536 Free PMC article.
Molecular cloning, heterologous expression and functional characterization of a novel translationally-controlled tumor protein (TCTP) family member from Loxosceles intermedia (brown spider) venom.
Sade YB, Bóia-Ferreira M, Gremski LH, da Silveira RB, Gremski W, Senff-Ribeiro A, Chaim OM, Veiga SS. Sade YB, et al. Int J Biochem Cell Biol. 2012 Jan;44(1):170-7. doi: 10.1016/j.biocel.2011.10.013. Epub 2011 Oct 29. Int J Biochem Cell Biol. 2012. PMID: 22051631 Free article.
Envenoming with brown spiders (Loxosceles genus) is common throughout the world. ...A protein that may be related to the effects of spider venom was identified from a previously obtained cDNA library of the L. intermedia venom gland. The amino acid sequence of this …
Envenoming with brown spiders (Loxosceles genus) is common throughout the world. ...A protein that may be related to the effects of s …
Identification of a direct hemolytic effect dependent on the catalytic activity induced by phospholipase-D (dermonecrotic toxin) from brown spider venom.
Chaves-Moreira D, Chaim OM, Sade YB, Paludo KS, Gremski LH, Donatti L, de Moura J, Mangili OC, Gremski W, da Silveira RB, Senff-Ribeiro A, Veiga SS. Chaves-Moreira D, et al. J Cell Biochem. 2009 Jul 1;107(4):655-66. doi: 10.1002/jcb.22148. J Cell Biochem. 2009. PMID: 19455508
Brown spiders have world-wide distribution and are the cause of health problems known as loxoscelism. ...By site-directed mutation at catalytic domain (histidine 12 by alanine), hemolysis and morphologic changes of erythrocytes (but not the toxin's ability of membrane bind …
Brown spiders have world-wide distribution and are the cause of health problems known as loxoscelism. ...By site-directed mutation at …