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Rutin alleviates EndMT by restoring autophagy through inhibiting HDAC1 via PI3K/AKT/mTOR pathway in diabetic kidney disease.
Dong R, Zhang X, Liu Y, Zhao T, Sun Z, Liu P, Xiang Q, Xiong J, Du X, Yang X, Gui D, Xu Y. Dong R, et al. Phytomedicine. 2023 Apr;112:154700. doi: 10.1016/j.phymed.2023.154700. Epub 2023 Feb 4. Phytomedicine. 2023. PMID: 36774842
RESULTS: Following 8 weeks of Rutin administration, db/db mice's kidney function and structure significantly improved. ...Furthermore, Rutin inhibits the phosphorylation of the PI3K / AKT/ mTOR pathway. ...
RESULTS: Following 8 weeks of Rutin administration, db/db mice's kidney function and structure significantly improved. ...Furthermore …
Rutin-Loaded Stimuli-Responsive Hydrogel for Anti-Inflammation.
Wang H, Wang L, Guo S, Liu Z, Zhao L, Qiao R, Li C. Wang H, et al. ACS Appl Mater Interfaces. 2022 Jun 1. doi: 10.1021/acsami.2c02295. Online ahead of print. ACS Appl Mater Interfaces. 2022. PMID: 35642748
An active flavonoid compound rutin was incorporated into a guanosine phenylborate hydrogel (GBR) by a stimuli-responsive borate ester linkage for the treatment of inflammatory bowel disease (IBD). ...In vivo activities of the GBR hydrogel showed higher therapeutic efficacy …
An active flavonoid compound rutin was incorporated into a guanosine phenylborate hydrogel (GBR) by a stimuli-responsive borate ester …
A Triple-Targeted Rutin-Based Self-Assembled Delivery Vector for Treating Ischemic Stroke by Vascular Normalization and Anti-Inflammation via ACE2/Ang1-7 Signaling.
Zhao T, He F, Zhao K, Yuxia L, Li H, Liu X, Cen J, Duan S. Zhao T, et al. ACS Cent Sci. 2023 Jun 5;9(6):1180-1199. doi: 10.1021/acscentsci.3c00377. eCollection 2023 Jun 28. ACS Cent Sci. 2023. PMID: 37396868 Free PMC article.
To overcome this challenge, we developed a triple-targeted self-assembled nanodelivery system, which combines the neuroprotective drug rutin with hyaluronic acid through esterification to form a conjugate, and then connected SS-31, a small peptide that can penetrate the bl …
To overcome this challenge, we developed a triple-targeted self-assembled nanodelivery system, which combines the neuroprotective drug ru …
Tartary buckwheat rutin: Accumulation, metabolic pathways, regulation mechanisms, and biofortification strategies.
Wang L, Zhao J, Mao Y, Liu L, Li C, Wu H, Zhao H, Wu Q. Wang L, et al. Plant Physiol Biochem. 2024 Mar;208:108503. doi: 10.1016/j.plaphy.2024.108503. Epub 2024 Mar 11. Plant Physiol Biochem. 2024. PMID: 38484679 Review.
Rutin is a significant flavonoid with strong antioxidant property and various therapeutic effects. ...Consequently, rutin has become the focus for tartary buckwheat breeders and has made considerable progress. ...
Rutin is a significant flavonoid with strong antioxidant property and various therapeutic effects. ...Consequently, rutin has …
Preparation, Evaluation and Characterization of Rutin-Chitooligosaccharide Complex.
Cao R, Ma Q, Fu Y, Zhou Z, Zhao X. Cao R, et al. Plant Foods Hum Nutr. 2019 Sep;74(3):328-333. doi: 10.1007/s11130-019-00740-y. Plant Foods Hum Nutr. 2019. PMID: 31172349
Compared to freeze-drying method, spray-drying method was more effective for preparing stable Rutin-COS complex. The spray-dried Rutin-COS showed increased water solubility, weakened bitterness, enhanced antioxidant and antibacterial activity compared to rutin …
Compared to freeze-drying method, spray-drying method was more effective for preparing stable Rutin-COS complex. The spray-dried R …
Rutin-activated adipose tissue thermogenesis is correlated with increased intestinal short-chain fatty acid levels.
Cheng L, Shi L, He C, Wang C, Lv Y, Li H, An Y, Dai H, Duan Y, Zhang H, Huang Y, Fu W, Meng Y, Zhao B. Cheng L, et al. Phytother Res. 2022 Jun;36(6):2495-2510. doi: 10.1002/ptr.7462. Epub 2022 Apr 21. Phytother Res. 2022. PMID: 35445769
In this study, we focused on the potential modulating effect of rutin on short-chain fatty acids (SCFAs) and the thermogenesis of BAT and WAT, aiming to elucidate the molecular mechanism of rutin in the treatment of obesity and T2DM. ...Moreover, rutin also i …
In this study, we focused on the potential modulating effect of rutin on short-chain fatty acids (SCFAs) and the thermogenesis of BAT …
Rutin prevents pyroptosis and M1 microglia via Nrf2/Mac-1/caspase-1-mediated inflammasome axis to improve POCD.
Ji Y, Ma Y, Ma Y, Wang Y, Zhao X, Jin D, Xu L, Ge S. Ji Y, et al. Int Immunopharmacol. 2024 Jan 25;127:111290. doi: 10.1016/j.intimp.2023.111290. Epub 2023 Dec 7. Int Immunopharmacol. 2024. PMID: 38064815
In vivo, aged mice were treated with rutin and surgery. In vitro, rutin, Nrf2 knockdown, MAC-1 overexpression and VX765, a caspase-1 inhibitor, were administration on BV2 microglial cells. RESULTS: Surgery led to compensatory increase in nuclear Nrf2 and rutin …
In vivo, aged mice were treated with rutin and surgery. In vitro, rutin, Nrf2 knockdown, MAC-1 overexpression and VX765, a cas …
Rutin hydrate relieves neuroinflammation in zebrafish models: Involvement of NF-kappaB pathway as a central network.
Hu Y, Jia K, Zhou Y, Chen L, Wang F, Yi X, Huang Y, Ge Y, Chen X, Liao D, Peng Y, Meng Y, Liu Y, Luo Q, Cheng B, Zhao Y, Lu H, Yuan W. Hu Y, et al. Fish Shellfish Immunol. 2023 Oct;141:109062. doi: 10.1016/j.fsi.2023.109062. Epub 2023 Sep 9. Fish Shellfish Immunol. 2023. PMID: 37678480
Neuroinflammation is prevalent in multiple brain diseases and may also lead to dementia, cognitive impairment, and impaired spatial memory function associated with neurodegenerative diseases. A neuroprotective and antioxidant flavonoid, rutin hydrate (RH), was evaluated fo …
Neuroinflammation is prevalent in multiple brain diseases and may also lead to dementia, cognitive impairment, and impaired spatial memory f …
Preparation and Characterization of Rutin-Loaded Zein-Carboxymethyl Starch Nanoparticles.
Li C, Chen L, McClements DJ, Peng X, Qiu C, Long J, Ji H, Zhao J, Zhou X, Jin Z. Li C, et al. Foods. 2022 Sep 13;11(18):2827. doi: 10.3390/foods11182827. Foods. 2022. PMID: 36140956 Free PMC article.
In this work, rutin (RT)-loaded zein-carboxymethyl starch (CMS) nanoparticles were successfully prepared by the antisolvent precipitation method. ...
In this work, rutin (RT)-loaded zein-carboxymethyl starch (CMS) nanoparticles were successfully prepared by the antisolvent precipita …
Rutin promotes osteogenic differentiation of periodontal ligament stem cells through the GPR30-mediated PI3K/AKT/mTOR signaling pathway.
Zhao B, Xiong Y, Zhang Y, Jia L, Zhang W, Xu X. Zhao B, et al. Exp Biol Med (Maywood). 2020 Mar;245(6):552-561. doi: 10.1177/1535370220903463. Epub 2020 Feb 9. Exp Biol Med (Maywood). 2020. PMID: 32036685 Free PMC article.
Rutin is one of the flavonoids found in fruits and vegetables. Recent reports have revealed that rutin is a major player in proliferation and bone development. ...The following is a short description of the main findings: rutin promotes the osteogenic differe …
Rutin is one of the flavonoids found in fruits and vegetables. Recent reports have revealed that rutin is a major player in pr …
355 results