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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1986 1
1991 2
1993 2
1994 1
1995 6
1996 2
1998 2
1999 4
2000 3
2001 12
2002 8
2003 9
2004 15
2005 9
2006 16
2007 16
2008 20
2009 19
2010 18
2011 24
2012 24
2013 23
2014 30
2015 34
2016 28
2017 38
2018 37
2019 48
2020 49
2021 72
2022 85
2023 66
2024 39

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682 results

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Page 1
Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.
Chen PJ, Hussmann JA, Yan J, Knipping F, Ravisankar P, Chen PF, Chen C, Nelson JW, Newby GA, Sahin M, Osborn MJ, Weissman JS, Adamson B, Liu DR. Chen PJ, et al. Cell. 2021 Oct 28;184(22):5635-5652.e29. doi: 10.1016/j.cell.2021.09.018. Epub 2021 Oct 14. Cell. 2021. PMID: 34653350 Free PMC article.
While prime editing enables precise sequence changes in DNA, cellular determinants of prime editing remain poorly understood. ...These findings enrich our understanding of prime editing and establish prime editing systems that show substantial improvem …
While prime editing enables precise sequence changes in DNA, cellular determinants of prime editing remain poorly understood. …
Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C.
Chu TT, Tu X, Yang K, Wu J, Repa JJ, Yan N. Chu TT, et al. Nature. 2021 Aug;596(7873):570-575. doi: 10.1038/s41586-021-03762-2. Epub 2021 Jul 21. Nature. 2021. PMID: 34290407 Free PMC article.
NPC1 interacts with STING and recruits it to the lysosome for degradation in both human and mouse cells. Notably, we find that knockout of Npc1 'primes' STING signalling by physically linking or 'tethering' STING to SREBP2 trafficking. Loss of NPC1 protein also 'boosts' ST …
NPC1 interacts with STING and recruits it to the lysosome for degradation in both human and mouse cells. Notably, we find that knockout of N …
CD47/SIRPα pathway mediates cancer immune escape and immunotherapy.
Jia X, Yan B, Tian X, Liu Q, Jin J, Shi J, Hou Y. Jia X, et al. Int J Biol Sci. 2021 Jul 25;17(13):3281-3287. doi: 10.7150/ijbs.60782. eCollection 2021. Int J Biol Sci. 2021. PMID: 34512146 Free PMC article. Review.
In contrast, CD47-SIRPalpha interaction blockade enhances cancer cell clearance by phagocytes such as macrophages and dendritic cells (DCs) to activate an innate immune response, whereas this process could promote antigen cross-presentation by antigen present cells (APCs) leading …
In contrast, CD47-SIRPalpha interaction blockade enhances cancer cell clearance by phagocytes such as macrophages and dendritic cells (DCs) …
Saturation variant interpretation using CRISPR prime editing.
Erwood S, Bily TMI, Lequyer J, Yan J, Gulati N, Brewer RA, Zhou L, Pelletier L, Ivakine EA, Cohn RD. Erwood S, et al. Nat Biotechnol. 2022 Jun;40(6):885-895. doi: 10.1038/s41587-021-01201-1. Epub 2022 Feb 21. Nat Biotechnol. 2022. PMID: 35190686
High-throughput functional characterization of genetic variants in their endogenous locus has so far been possible only with methods that rely on homology-directed repair, which are limited by low editing efficiencies. Here, we adapted CRISPR prime editing for high-through …
High-throughput functional characterization of genetic variants in their endogenous locus has so far been possible only with methods that re …
Dual-role transcription factors stabilize intermediate expression levels.
He J, Huo X, Pei G, Jia Z, Yan Y, Yu J, Qu H, Xie Y, Yuan J, Zheng Y, Hu Y, Shi M, You K, Li T, Ma T, Zhang MQ, Ding S, Li P, Li Y. He J, et al. Cell. 2024 Apr 10:S0092-8674(24)00314-3. doi: 10.1016/j.cell.2024.03.023. Online ahead of print. Cell. 2024. PMID: 38631355
STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death.
Wu J, Chen YJ, Dobbs N, Sakai T, Liou J, Miner JJ, Yan N. Wu J, et al. J Exp Med. 2019 Apr 1;216(4):867-883. doi: 10.1084/jem.20182192. Epub 2019 Mar 18. J Exp Med. 2019. PMID: 30886058 Free PMC article.
Mechanistically, STING-N154S disrupts calcium homeostasis in T cells, thus intrinsically primes T cells to become hyperresponsive to T cell receptor signaling-induced ER stress and the UPR, leading to cell death. This intrinsic priming effect is mediated through a n …
Mechanistically, STING-N154S disrupts calcium homeostasis in T cells, thus intrinsically primes T cells to become hyperresponsive to …
Distracting Through Procedural Pain and Distress Using Virtual Reality and Guided Imagery in Pediatric, Adolescent, and Young Adult Patients: Randomized Controlled Trial.
Hoag JA, Karst J, Bingen K, Palou-Torres A, Yan K. Hoag JA, et al. J Med Internet Res. 2022 Apr 18;24(4):e30260. doi: 10.2196/30260. J Med Internet Res. 2022. PMID: 35436209 Free PMC article. Clinical Trial.
CONCLUSIONS: In our sample, VR worked as well as GI to manage the pain and distress associated with common procedures experienced by children with acute or chronic illnesses. Children who are primed for pain based on beliefs about pain or because of their history of chroni …
CONCLUSIONS: In our sample, VR worked as well as GI to manage the pain and distress associated with common procedures experienced by childre …
Cross-Modal Somatosensory Repetition Priming and Speech Processing.
Namasivayam AK, Yan T, Bali R, Hayden D, van Lieshout P. Namasivayam AK, et al. J Integr Neurosci. 2022 Aug 19;21(5):146. doi: 10.31083/j.jin2105146. J Integr Neurosci. 2022. PMID: 36137962 Free article.
The first group consisted of twenty-three native English speakers who received somatosensory priming stimulation to their oro-facial structures (either to labial corners or under the jaw). The second group consisted of ten native English speakers who participated in a cont …
The first group consisted of twenty-three native English speakers who received somatosensory priming stimulation to their oro-facial …
Close the cancer-immunity cycle by integrating lipid nanoparticle-mRNA formulations and dendritic cell therapy.
Zhang Y, Hou X, Du S, Xue Y, Yan J, Kang DD, Zhong Y, Wang C, Deng B, McComb DW, Dong Y. Zhang Y, et al. Nat Nanotechnol. 2023 Nov;18(11):1364-1374. doi: 10.1038/s41565-023-01453-9. Epub 2023 Jul 27. Nat Nanotechnol. 2023. PMID: 37500773
This promotes the secretion of multiple cytokines and chemokines, and the upregulation of co-stimulatory molecules on dendritic cells, which are crucial for reprogramming the tumour microenvironment and priming the T-cell responses. After dendritic cells present tumour-ass …
This promotes the secretion of multiple cytokines and chemokines, and the upregulation of co-stimulatory molecules on dendritic cells, which …
682 results