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Contrasting effects of adenosine A1 and A2 receptor ligands in different chemoconvulsive rodent models.
Klitgaard H, Knutsen LJ, Thomsen C. Klitgaard H, et al. Eur J Pharmacol. 1993 Oct 5;242(3):221-8. doi: 10.1016/0014-2999(93)90245-d. Eur J Pharmacol. 1993. PMID: 7904242
The selective adenosine A1 receptor agonists N-cyclopentyladenosine (CPA) and R-N-(phenylisopropyl) adenosine (R-PIA) in doses of 1 and 10 mg/kg i.p. potentiated seizures induced by the selective adenosine A1 receptor antagonist 8-[4-[[[[(2-aminoethyl)amino]carbonyl]methyl …
The selective adenosine A1 receptor agonists N-cyclopentyladenosine (CPA) and R-N-(phenylisopropyl) adenosine (R-PIA) in doses of 1 a …
N-substituted adenosines as novel neuroprotective A(1) agonists with diminished hypotensive effects.
Knutsen LJ, Lau J, Petersen H, Thomsen C, Weis JU, Shalmi M, Judge ME, Hansen AJ, Sheardown MJ. Knutsen LJ, et al. J Med Chem. 1999 Sep 9;42(18):3463-77. doi: 10.1021/jm960682u. J Med Chem. 1999. PMID: 10479279
However, the new compounds we describe exhibit diminished cardiovascular effects in both anesthetized and awake rats when compared to reference A(1) agonists such as (R)-phenylisopropyladenosine (R-PIA, 5), N-cyclopentyladenosine (CPA, 2), 4, N-[(1S,trans)-2-hydroxycyclope …
However, the new compounds we describe exhibit diminished cardiovascular effects in both anesthetized and awake rats when compared to refere …