Enhanced gene expression and reduced toxicity in mice using polyplexes of low-molecular-weight poly(ethylene imine) for pulmonary gene delivery.
Kleemann E, Jekel N, Dailey LA, Roesler S, Fink L, Weissmann N, Schermuly R, Gessler T, Schmehl T, Roberts CJ, Seeger W, Kissel T.
Kleemann E, et al.
J Drug Target. 2009 Sep;17(8):638-51. doi: 10.1080/10611860903106414.
J Drug Target. 2009.
PMID: 19589123
The aim of this study was to elicit improved gene expression and decreased cytotoxicity for pulmonary gene therapy by replacing the commonly used carrier 25 kDa branched poly(ethylene imine) (BPEI) by two PEI derivatives, low-molecular-weight PEI (LMWPEI) and polyethylene glycol- …
The aim of this study was to elicit improved gene expression and decreased cytotoxicity for pulmonary gene therapy by replacing the commonly …