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1998 2
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Page 1
The relevance of kalikrein-kinin system via activation of B2 receptor in LPS-induced fever in rats.
Soares DM, Santos DR, Rummel C, Ott D, Melo MCC, Roth J, Calixto JB, Souza GEP. Soares DM, et al. Neuropharmacology. 2017 Nov;126:84-96. doi: 10.1016/j.neuropharm.2017.08.019. Epub 2017 Aug 19. Neuropharmacology. 2017. PMID: 28826826
BK (i.c.v.) increased the CSF PGE(2)concentration. Effect abolished by indomethacin (i.p.). CONCLUSIONS: LPS activates endogenous kalikrein-kinin system leading to production of BK, which by acting on B(2)-receptors of POA cells causes prostaglandin synthesis that i …
BK (i.c.v.) increased the CSF PGE(2)concentration. Effect abolished by indomethacin (i.p.). CONCLUSIONS: LPS activates endogen …
P2X7 receptor blockade decreases inflammation, apoptosis, and enteric neuron loss during Clostridioides difficile toxin A-induced ileitis in mice.
Santos AAQA, Costa DVS, Foschetti DA, Duarte ASG, Martins CS, Soares PMG, Castelucci P, Brito GAC. Santos AAQA, et al. World J Gastroenterol. 2022 Aug 14;28(30):4075-4088. doi: 10.3748/wjg.v28.i30.4075. World J Gastroenterol. 2022. PMID: 36157120 Free PMC article.
To investigate the role of the P2X7 receptor, Brilliant Blue G (50 mg/kg, i.p.), which is a nonspecific P2X7 receptor antagonist, or A438079 (0.7 mug/mouse, i.p.), which is a competitive P2X7 receptor antagonist, were injected one hour prior to TcdA ch …
To investigate the role of the P2X7 receptor, Brilliant Blue G (50 mg/kg, i.p.), which is a nonspecific P2X7 receptor antagoni …
M1 muscarinic receptors are necessary for retrieval of remote context fear memory.
Patricio RR, Soares JC, Oliveira MG. Patricio RR, et al. Physiol Behav. 2017 Feb 1;169:202-207. doi: 10.1016/j.physbeh.2016.12.008. Epub 2016 Dec 7. Physiol Behav. 2017. PMID: 27940145 Free article.
Male Wistar rats were trained, and after 1 or 28days, the rats received dicyclomine (16 or 32mg/kg, intraperitoneally, i.p.) and were tested in CFC, tone fear conditioning (TFC) and IA tasks. ...
Male Wistar rats were trained, and after 1 or 28days, the rats received dicyclomine (16 or 32mg/kg, intraperitoneally, i.p.) a …
The antipyretic effect of dipyrone is unrelated to inhibition of PGE(2) synthesis in the hypothalamus.
Malvar Ddo C, Soares DM, Fabrício AS, Kanashiro A, Machado RR, Figueiredo MJ, Rae GA, de Souza GE. Malvar Ddo C, et al. Br J Pharmacol. 2011 Mar;162(6):1401-9. doi: 10.1111/j.1476-5381.2010.01150.x. Br J Pharmacol. 2011. PMID: 21133897 Free PMC article.
For a better understanding of the mechanisms by which dipyrone exerts antipyresis, we have investigated its effects on fever and changes in PGE(2) content in plasma, CSF and hypothalamus induced by either LPS or ET-1. EXPERIMENTAL APPROACH: Rats were given (i.p.) di …
For a better understanding of the mechanisms by which dipyrone exerts antipyresis, we have investigated its effects on fever and changes in …
Effects of methionine supplementation on the expression of protein deposition-related genes in acute heat stress-exposed broilers.
Del Vesco AP, Gasparino E, Grieser DO, Zancanela V, Voltolini DM, Khatlab AS, Guimarães SE, Soares MA, Oliveira Neto AR. Del Vesco AP, et al. PLoS One. 2015 Feb 25;10(2):e0115821. doi: 10.1371/journal.pone.0115821. eCollection 2015. PLoS One. 2015. PMID: 25714089 Free PMC article.
Starter period: The HS animals presented increased plasma creatinine content (P<0.0001) and the highest CTSL2 gene expression (P<0.0001). The methionine supplementation increased the IGF-I (P = 0.0144) and GHR (P = 0.0011) gene expression and decreased the CTS …
Starter period: The HS animals presented increased plasma creatinine content (P<0.0001) and the highest CTSL2 gene expression (P<0.000 …
Effects of the M1 muscarinic antagonist dicyclomine on emotional memory retrieval.
Soares JC, Perfetto JG, Antonio BB, Oliveira MG. Soares JC, et al. Behav Neurosci. 2016 Feb;130(1):29-35. doi: 10.1037/bne0000113. Epub 2015 Nov 30. Behav Neurosci. 2016. PMID: 26619084
Twenty-four hr later, they were treated with different doses of dicyclomine (16, 32, or 64 mg/kg, i.p.) or with saline 30 min before the test session. The results showed that dicyclomine at doses of 16 and 32 mg/kg impaired CFC without interfering with IA performanc …
Twenty-four hr later, they were treated with different doses of dicyclomine (16, 32, or 64 mg/kg, i.p.) or with saline 30 min …
A crucial role for IL-6 in the CNS of rats during fever induced by the injection of live E. coli.
Soares DM, Figueiredo MJ, Martins JM, Machado RR, Sorgi C, Faciolli LH, Alves-Filho JC, Cunha FQ, Souza GE. Soares DM, et al. Med Microbiol Immunol. 2012 Feb;201(1):47-60. doi: 10.1007/s00430-011-0204-3. Epub 2011 Jun 5. Med Microbiol Immunol. 2012. PMID: 21643979
Depending on the number of colony-forming units (CFU) injected i.p., administration of E. coli induced a long-lasting increase in bT of male Wistar rats. ...TNF-alpha, IL-1beta, and IL-6 were detected at 3 h in serum of animals injected i.p. with E. co …
Depending on the number of colony-forming units (CFU) injected i.p., administration of E. coli induced a long-lasting increase …
The histamine H4 receptor antagonist 1-[(5-chloro-2,3-dihydro-1-benzofuran-2-yl)methyl]-4-methyl-piperazine(LINS01007) prevents the development of DSS-induced colitis in mice.
Lippi BK, Fernandes GAB, Azevedo GA, Negreiros NGS, Soares AW, Landgraf MA, Fernandes JPS, Landgraf RG. Lippi BK, et al. Int Immunopharmacol. 2024 May 30;133:112128. doi: 10.1016/j.intimp.2024.112128. Epub 2024 Apr 22. Int Immunopharmacol. 2024. PMID: 38652966
Experimental acute colitis was induced in male BALB/c mice (n = 5-10) by administering 3 % DSS in the drinking water for six days. The test compound LINS01007 was administered daily i.p. (5 mg/kg) and compared to control group without treatment. ...
Experimental acute colitis was induced in male BALB/c mice (n = 5-10) by administering 3 % DSS in the drinking water for six days. The test …
21 results