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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 1
1957 1
1960 1
1961 2
1965 4
1966 8
1967 17
1968 22
1969 31
1970 42
1971 18
1972 29
1973 30
1974 49
1975 28
1976 44
1977 39
1978 29
1979 41
1980 33
1981 34
1982 53
1983 41
1984 46
1985 39
1986 39
1987 189
1988 393
1989 426
1990 466
1991 496
1992 498
1993 563
1994 622
1995 580
1996 621
1997 664
1998 689
1999 651
2000 737
2001 682
2002 610
2003 637
2004 651
2005 630
2006 609
2007 588
2008 642
2009 634
2010 601
2011 600
2012 646
2013 621
2014 986
2015 1125
2016 1189
2017 1213
2018 1128
2019 1152
2020 1163
2021 1165
2022 972
2023 864
2024 334

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25,833 results

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Page 1
TMPRSS2 is a functional receptor for human coronavirus HKU1.
Saunders N, Fernandez I, Planchais C, Michel V, Rajah MM, Baquero Salazar E, Postal J, Porrot F, Guivel-Benhassine F, Blanc C, Chauveau-Le Friec G, Martin A, Grzelak L, Oktavia RM, Meola A, Ahouzi O, Hoover-Watson H, Prot M, Delaune D, Cornelissen M, Deijs M, Meriaux V, Mouquet H, Simon-Lorière E, van der Hoek L, Lafaye P, Rey F, Buchrieser J, Schwartz O. Saunders N, et al. Nature. 2023 Dec;624(7990):207-214. doi: 10.1038/s41586-023-06761-7. Epub 2023 Oct 25. Nature. 2023. PMID: 37879362 Free article.
Catalytically inactive TMPRSS2 mutants do not cleave HKU1 spike but allow pseudovirus infection. Furthermore, TMPRSS2 binds with high affinity to the HKU1 receptor binding domain (Kd 334 and 137 nM for HKU1A and HKU1B genotypes) but not to SARS-CoV-2. Conserved amin …
Catalytically inactive TMPRSS2 mutants do not cleave HKU1 spike but allow pseudovirus infection. Furthermore, TMPRSS2 binds with high …
Rabies virus P protein binds to TBK1 and interferes with the formation of innate immunity-related liquid condensates.
Scrima N, Le Bars R, Nevers Q, Glon D, Chevreux G, Civas A, Blondel D, Lagaudrière-Gesbert C, Gaudin Y. Scrima N, et al. Cell Rep. 2023 Jan 31;42(1):111949. doi: 10.1016/j.celrep.2022.111949. Epub 2023 Jan 4. Cell Rep. 2023. PMID: 36640307 Free article.
Here, using a global mass spectrometry approach, we show that RABV P binds to TBK1, a kinase located at the crossroads of many interferon induction pathways, resulting in innate immunity inhibition. ...These condensates can form larger aggregates having ring-like structure …
Here, using a global mass spectrometry approach, we show that RABV P binds to TBK1, a kinase located at the crossroads of many interf …
Avian cryptochrome 4 binds superoxide.
Deviers J, Cailliez F, de la Lande A, Kattnig DR. Deviers J, et al. Comput Struct Biotechnol J. 2023 Dec 18;26:11-21. doi: 10.1016/j.csbj.2023.12.009. eCollection 2024 Dec. Comput Struct Biotechnol J. 2023. PMID: 38204818 Free PMC article.
The positively charged "crypt" region that leads to the flavin binding pocket transiently binds O2- at 5 flexible binding sites centred on arginine residues. Typical binding times amounted to tens of nanoseconds, but exceptional binding events e …
The positively charged "crypt" region that leads to the flavin binding pocket transiently binds O2- at 5 flexible binding …
APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans.
Tsiantoulas D, Eslami M, Obermayer G, Clement M, Smeets D, Mayer FJ, Kiss MG, Enders L, Weißer J, Göderle L, Lambert J, Frommlet F, Mueller A, Hendrikx T, Ozsvar-Kozma M, Porsch F, Willen L, Afonyushkin T, Murphy JE, Fogelstrand P, Donzé O, Pasterkamp G, Hoke M, Kubicek S, Jørgensen HF, Danchin N, Simon T, Scharnagl H, März W, Borén J, Hess H, Mallat Z, Schneider P, Binder CJ. Tsiantoulas D, et al. Nature. 2021 Sep;597(7874):92-96. doi: 10.1038/s41586-021-03818-3. Epub 2021 Aug 25. Nature. 2021. PMID: 34433968
Mechanistically, we demonstrate that APRIL confers atheroprotection by binding to heparan sulfate chains of heparan-sulfate proteoglycan 2 (HSPG2), which limits the retention of low-density lipoproteins, accumulation of macrophages and formation of necrotic cores. ...Treat …
Mechanistically, we demonstrate that APRIL confers atheroprotection by binding to heparan sulfate chains of heparan-sulfate proteogly …
The collagen ColQ binds to LRP4 and regulates the activation of the Muscle-Specific Kinase-LRP4 receptor complex by agrin at the neuromuscular junction.
Uyen Dao TM, Barbeau S, Messéant J, Della-Gaspera B, Bouceba T, Semprez F, Legay C, Dobbertin A. Uyen Dao TM, et al. J Biol Chem. 2023 Aug;299(8):104962. doi: 10.1016/j.jbc.2023.104962. Epub 2023 Jun 23. J Biol Chem. 2023. PMID: 37356721 Free PMC article.
Using coimmunoprecipitation, pull-down, plate-binding assays, and surface plasmon resonance, we show that ColQ binds directly to LRP4 but not to MuSK and that ColQ interacts indirectly with MuSK through LRP4. In addition, we show that the LRP4 N-terminal region, whi …
Using coimmunoprecipitation, pull-down, plate-binding assays, and surface plasmon resonance, we show that ColQ binds directly …
Stimulus-response bindings in priming.
Henson RN, Eckstein D, Waszak F, Frings C, Horner AJ. Henson RN, et al. Trends Cogn Sci. 2014 Jul;18(7):376-84. doi: 10.1016/j.tics.2014.03.004. Epub 2014 Apr 24. Trends Cogn Sci. 2014. PMID: 24768034 Free PMC article. Review.
People can rapidly form arbitrary associations between stimuli and the responses they make in the presence of those stimuli. Such stimulus-response (S-R) bindings, when retrieved, affect the way that people respond to the same, or related, stimuli. Only recently, however, …
People can rapidly form arbitrary associations between stimuli and the responses they make in the presence of those stimuli. Such stimulus-r …
IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spike.
Gatineau J, Nidercorne C, Dupont A, Puiffe ML, Cohen JL, Molinier-Frenkel V, Niedergang F, Castellano F. Gatineau J, et al. Front Immunol. 2022 Sep 5;13:982839. doi: 10.3389/fimmu.2022.982839. eCollection 2022. Front Immunol. 2022. PMID: 36131918 Free PMC article.
Here, we identified transmembrane serine protease 13 (TMPRSS13) as an immune cell-expressed surface protein that binds IL4I1. TMPRSS13 is a paralog of TMPRSS2, of which the protease activity participates in the cleavage of SARS-CoV-2 spike protein and facilitates virus ind …
Here, we identified transmembrane serine protease 13 (TMPRSS13) as an immune cell-expressed surface protein that binds IL4I1. TMPRSS1 …
Fibrinogen αC domain: Its importance in physiopathology.
Soria J, Mirshahi S, Mirshahi SQ, Varin R, Pritchard LL, Soria C, Mirshahi M. Soria J, et al. Res Pract Thromb Haemost. 2019 Feb 15;3(2):173-183. doi: 10.1002/rth2.12183. eCollection 2019 Apr. Res Pract Thromb Haemost. 2019. PMID: 31011701 Free PMC article. Review.
In Alzheimer's disease, amyloid beta peptide (Abeta) is increased and binds to the alphaC domain of normal fibrinogen, triggering increased fibrin(ogen) deposition in patients' brain parenchyma. ...Mutation of an amino acid into cysteine (as in fibrinogens Dusart and Carac …
In Alzheimer's disease, amyloid beta peptide (Abeta) is increased and binds to the alphaC domain of normal fibrinogen, triggering inc …
Among the recombinant TSPOs, the BcTSPO.
Issop L, Duma L, Finet S, Lequin O, Lacapère JJ. Issop L, et al. Biochimie. 2024 Jan 25:S0300-9084(24)00029-4. doi: 10.1016/j.biochi.2024.01.011. Online ahead of print. Biochimie. 2024. PMID: 38280504 Free article.
For each of the three ligands, (1)H-(15)N HSQC titration NMR experiments suggest that different amino acids of BcTSPO binding cavity are involved in the interaction. PPIX, an intermediate of heme biosynthesis, binds to the cavity of BcTSPO and its fluorescence can b …
For each of the three ligands, (1)H-(15)N HSQC titration NMR experiments suggest that different amino acids of BcTSPO binding cavity …
The BRCA2 R2645G variant increases DNA binding and induces hyper-recombination.
Alvaro-Aranda L, Petitalot A, Djeghmoum Y, Panigada D, Singh JK, Ehlén Å, Vugic D, Martin C, Miron S, Contreras-Perez A, Nhiri N, Boucherit V, Lafitte P, Dumoulin I, Rouleau E, Jacquet E, Feliubadaló L, Del Valle J, Stoppa-Lyonnet D, Zinn-Justin S, Lázaro C, Caputo SM, Carreira A. Alvaro-Aranda L, et al. Nucleic Acids Res. 2023 Dec 24:gkad1222. doi: 10.1093/nar/gkad1222. Online ahead of print. Nucleic Acids Res. 2023. PMID: 38142462
BRCA2 tumor suppressor protein ensures genome integrity by mediating DNA repair via homologous recombination (HR). This function is executed in part by its canonical DNA binding domain located at the C-terminus (BRCA2CTD), the only folded domain of the protein. Most germli …
BRCA2 tumor suppressor protein ensures genome integrity by mediating DNA repair via homologous recombination (HR). This function is executed …
25,833 results
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