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Modulation of metabolism and cytotoxicity of cytosine arabinoside with N-(phosphon)-acetyl-L-aspartate in human leukemic blast cells and cell lines.
Noordhuis P, Kazemier KM, Kasperrs GJ, Peters GJ. Noordhuis P, et al. Leuk Res. 1996 Feb;20(2):127-34. doi: 10.1016/0145-2126(95)00071-2. Leuk Res. 1996. PMID: 8628011
Inhibition of the de novo synthesis of these pyrimidine nucleotides by N-(phosphon)-acetyl-L-aspartate (PALA) may enhance the cytotoxicity of Ara-C. We therefore studied the effect of PALA on Ara-C cytotoxicity and on Ara-CTP accumulation and in …
Inhibition of the de novo synthesis of these pyrimidine nucleotides by N-(phosphon)-acetyl-L-aspartate (PALA) may enhance the cytotox …
Differential effect of N-(phosphonacetyl)-L-aspartate on 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity in human leukemia and normal bone marrow progenitors.
Grant S, Rauscher F 3rd, Cadman E. Grant S, et al. Cancer Res. 1982 Oct;42(10):4007-13. Cancer Res. 1982. PMID: 6955007
HL-60 cells exposed to 0.1 mM PALA for 12 hr accumulated 58.7 pmol ara-C per 10(6) cells after a 45-min exposure to 1 microM ara-C, compared to 27.8 pmol ara-C per 10(6) cells in untreated control cells. ...In contrast, exposure of normal human bone ma …
HL-60 cells exposed to 0.1 mM PALA for 12 hr accumulated 58.7 pmol ara-C per 10(6) cells after a 45-min exposure to 1 microM …
Chemotherapeutic evaluation using clinical criteria in spontaneous, autochthonous murine breast tumors.
Stolfi RL, Stolfi LM, Sawyer RC, Martin DS. Stolfi RL, et al. J Natl Cancer Inst. 1988 Mar 2;80(1):52-5. doi: 10.1093/jnci/80.1.52. J Natl Cancer Inst. 1988. PMID: 3339639
Six drugs, three of which are considered to be active against human breast cancer [melphalan (PAM), cyclophosphamide (CTX), and 5-fluorouracil (FUra)] and three of which have failed to demonstrate activity against human breast cancer [N-phosphonacetyl-L-aspartate (PALA), c …
Six drugs, three of which are considered to be active against human breast cancer [melphalan (PAM), cyclophosphamide (CTX), and 5-fluorourac …
Therapeutic synergism of tiazofurin and selected antitumor drugs against sensitive and resistant P388 leukemia in mice.
Harrison SD Jr, O'Dwyer PJ, Trader MW. Harrison SD Jr, et al. Cancer Res. 1986 Jul;46(7):3396-400. Cancer Res. 1986. PMID: 3708573
Tiazofurin plus cisplatin or the 5'-palmitate of 1-beta-D-arabinofuranosylcytosine (ara-C) was evaluated against the parent P388/O leukemia line. Tiazofurin plus 6-thioguanine was evaluated against the ara-C-resistant P388. ...Optimal single-agent and combination do …
Tiazofurin plus cisplatin or the 5'-palmitate of 1-beta-D-arabinofuranosylcytosine (ara-C) was evaluated against the parent P388/O le …
Effect of deoxycytidine on the in vitro response of human leukemia cells to inhibitors of de novo pyrimidine biosynthesis.
Bhalla K, Grant S. Bhalla K, et al. Cancer Chemother Pharmacol. 1987;19(3):226-32. doi: 10.1007/BF00252977. Cancer Chemother Pharmacol. 1987. PMID: 3581416
The effect of high concentrations of exogenous dCyd on the growth inhibitory properties of several inhibitors of de novo pyrimidine biosynthesis (dThd, 3-DAU, PALA, PF) was examined in three cultured human leukemic cell lines (HL-60, K-562, KG-1), and a dCyd kinase-deficie …
The effect of high concentrations of exogenous dCyd on the growth inhibitory properties of several inhibitors of de novo pyrimidine biosynth …
[Increase of dose intensity by pharmacomodulation. General concepts and therapeutic applications].
Milano G. Milano G. Bull Cancer. 1995;82 Suppl 1:37s-41s. Bull Cancer. 1995. PMID: 7626853 French.
The second level for pharmacomodulation concerns pharmacological interferences with metabolic pathways controlling the activity of anticancer agents and particularly the antimetabolites like ara-C and 5-FU. The use of hydroxyurea or PALA in the case of 5-FU are good …
The second level for pharmacomodulation concerns pharmacological interferences with metabolic pathways controlling the activity of anticance …