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108 results

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Page 1
Nanoliposomal Ratiometric Fluorescent Probe toward ONOO(-) Flux.
Zhang J, Kan J, Sun Y, Won M, Kim JH, Zhang W, Zhou J, Qian Z, Kim JS. Zhang J, et al. ACS Appl Bio Mater. 2021 Mar 15;4(3):2080-2088. doi: 10.1021/acsabm.0c01178. Epub 2020 Nov 6. ACS Appl Bio Mater. 2021. PMID: 35014335
Peroxynitrite (ONOO(-)), a powerful biological oxidant, is produced in the mitochondria and reacts with many biomolecular targets under various pathological conditions, leading to a range of disease states. ...In addition, the practical applications of the nanoprobe to ima …
Peroxynitrite (ONOO(-)), a powerful biological oxidant, is produced in the mitochondria and reacts with many biomolecular targets und …
An Activity-Based Fluorescent Probe for Imaging Fluctuations of Peroxynitrite (ONOO(-) ) in the Alzheimer's Disease Brain.
Wang P, Yu L, Gong J, Xiong J, Zi S, Xie H, Zhang F, Mao Z, Liu Z, Kim JS. Wang P, et al. Angew Chem Int Ed Engl. 2022 Sep 5;61(36):e202206894. doi: 10.1002/anie.202206894. Epub 2022 Jul 27. Angew Chem Int Ed Engl. 2022. PMID: 35789171
Peroxynitrite (ONOO(-) ) plays a critical role in Alzheimer's disease (AD). To reveal the ONOO(-) influx in AD brains, an activatable activity-based fluorescence probe Rd-DPA3 was designed by a structure-modulated strategy. Taking advantage of ONOO(-) -initia …
Peroxynitrite (ONOO(-) ) plays a critical role in Alzheimer's disease (AD). To reveal the ONOO(-) influx in AD brains, an acti …
Active components from Artemisia iwayomogi displaying ONOO(-) scavenging activity.
Kim AR, Zou YN, Park TH, Shim KH, Kim MS, Kim ND, Kim JD, Bae SJ, Choi JS, Chung HY. Kim AR, et al. Phytother Res. 2004 Jan;18(1):1-7. doi: 10.1002/ptr.1358. Phytother Res. 2004. PMID: 14750192
Peroxynitrite (ONOO(-)) is one of cytotoxic species produced by the reaction between superoxide (*O(2) (-)) and nitric oxide (NO). The main aim of this study was to identify ONOO(-) scavenging constituents from herbs. Methanolic extracts derived from one hundred thi …
Peroxynitrite (ONOO(-)) is one of cytotoxic species produced by the reaction between superoxide (*O(2) (-)) and nitric oxide (NO). Th …
A Two-Photon Fluorescent Probe for Imaging Endogenous ONOO(-) near NMDA Receptors in Neuronal Cells and Hippocampal Tissues.
Lee D, Lim CS, Ko G, Kim D, Cho MK, Nam SJ, Kim HM, Yoon J. Lee D, et al. Anal Chem. 2018 Aug 7;90(15):9347-9352. doi: 10.1021/acs.analchem.8b01960. Epub 2018 Jul 13. Anal Chem. 2018. PMID: 29968465
More importantly, the probe can be employed along with two-photon fluorescence microscopy to detect endogenous ONOO(-) near NMDA receptors in neuronal cells as well as in hippocampal tissues. The results suggest that the probe has the potential of serving as a useful imagi …
More importantly, the probe can be employed along with two-photon fluorescence microscopy to detect endogenous ONOO(-) near NMDA rece …
Zingerone as an antioxidant against peroxynitrite.
Shin SG, Kim JY, Chung HY, Jeong JC. Shin SG, et al. J Agric Food Chem. 2005 Sep 21;53(19):7617-22. doi: 10.1021/jf051014x. J Agric Food Chem. 2005. PMID: 16159194
Zingerone inhibited the formation of ONOO(-)-mediated tyrosine nitration through electron donation, nitration of bovine serum albumin (BSA) by ONOO(-), and intracellular RS and ONOO(-). The present study suggests that zingerone has an efficient ONOO(-) …
Zingerone inhibited the formation of ONOO(-)-mediated tyrosine nitration through electron donation, nitration of bovine serum albumin …
Role of protein tyrosine nitration in neurodegenerative diseases and atherosclerosis.
Lee JR, Kim JK, Lee SJ, Kim KP. Lee JR, et al. Arch Pharm Res. 2009 Aug;32(8):1109-18. doi: 10.1007/s12272-009-1802-0. Epub 2009 Aug 29. Arch Pharm Res. 2009. PMID: 19727603 Review.
Nitric oxide generates reactive nitrosative species, such as peroxynitrite (ONOO(-)) that may be involved in a number of diseases. ONOO(-) can mediate protein tyrosine nitration which causes structural changes of affected proteins and leads to their inactivation. .. …
Nitric oxide generates reactive nitrosative species, such as peroxynitrite (ONOO(-)) that may be involved in a number of diseases. …
Hesperetin: a potent antioxidant against peroxynitrite.
Kim JY, Jung KJ, Choi JS, Chung HY. Kim JY, et al. Free Radic Res. 2004 Jul;38(7):761-9. doi: 10.1080/10715760410001713844. Free Radic Res. 2004. PMID: 15453641
Because of the lack of endogenous enzymes to thwart ONOO- activation, developing a specific ONOO- scavenger is remarkably important. In this study, the ability of hesperetin (3',5,7-trihydroxy-4-methoxyflavanone) to scavenge ONOO- and to protect cells against …
Because of the lack of endogenous enzymes to thwart ONOO- activation, developing a specific ONOO- scavenger is remarkably impo …
A fluorescent ESIPT-based benzimidazole platform for the ratiometric two-photon imaging of ONOO(-) in vitro and ex vivo.
Odyniec ML, Park SJ, Gardiner JE, Webb EC, Sedgwick AC, Yoon J, Bull SD, Kim HM, James TD. Odyniec ML, et al. Chem Sci. 2020 Jun 16;11(28):7329-7334. doi: 10.1039/d0sc02347g. eCollection 2020 Jul 28. Chem Sci. 2020. PMID: 33033609 Free PMC article.
In this work, we have developed an ESIPT-based benzimidazole platform (MO-E1 and MO-E2) for the two-photon cell imaging of ONOO(-) and a potential ONOO(-)-activated theranostic scaffold (MO-E3). Each benzimidazole platform, MO-E1-3, were shown to rapidly detect O …
In this work, we have developed an ESIPT-based benzimidazole platform (MO-E1 and MO-E2) for the two-photon cell imaging of ONOO(-) an …
Phosphinate-benzoindocyanin fluorescent probe for endogenous mitochondrial peroxynitrite detection in living cells and gallbladder access in inflammatory zebrafish animal models.
Sonawane PM, Lee W, Kim Y, Roychaudhury A, Bhosale VK, Kim D, Park HS, Kim CH, Churchill DG. Sonawane PM, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2022 Feb 15;267(Pt 2):120568. doi: 10.1016/j.saa.2021.120568. Epub 2021 Nov 1. Spectrochim Acta A Mol Biomol Spectrosc. 2022. PMID: 34774434
Hence, the precise and selective monitoring of ONOO(-) is imperative for elucidating its interplay and roles in pathological and physiological processes. Herein, we present a novel diphenyl phosphinate-masked benzoindocyanin "turn-on" fluorogenic probe to help detect mitoc …
Hence, the precise and selective monitoring of ONOO(-) is imperative for elucidating its interplay and roles in pathological and phys …
Cytotoxic and cytoprotective actions of O2- and NO (ONOO-) are determined both by cellular GSH level and HO activity in macrophages.
Srisook K, Kim C, Cha YN. Srisook K, et al. Methods Enzymol. 2005;396:414-24. doi: 10.1016/S0076-6879(05)96035-7. Methods Enzymol. 2005. PMID: 16291250
However, macrophages can survive the toxicity of ONOO- by replenishing the depleted GSH level and by inducing HO-1 expression. In macrophages exposed to conditions overproducing O2-, NO, or ONOO-, the cellular level of GSH decreased rapidly, and when excessive, cell …
However, macrophages can survive the toxicity of ONOO- by replenishing the depleted GSH level and by inducing HO-1 expression. In mac …
108 results