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Page 1
Bone morphogenic protein and its application in trauma cases: a current concept update.
Vaibhav B, Nilesh P, Vikram S, Anshul C. Vaibhav B, et al. Injury. 2007 Nov;38(11):1227-35. doi: 10.1016/j.injury.2006.12.012. Epub 2007 Feb 20. Injury. 2007. PMID: 17307180 Review.
Animal studies and limited human studies have proven their efficacy as an alternative or enhancer of autologus bone graft in bone regeneration. The action of BMP is mediated through receptor kinases and transcription factors called Smads that regulate the expression of tar …
Animal studies and limited human studies have proven their efficacy as an alternative or enhancer of autologus bone graft in bone regenerati …
Computational Design, Synthesis, and Bioevaluation of 2-(Pyrimidin-4-yl)oxazole-4-carboxamide Derivatives: Dual Inhibition of EGFRWT and EGFRT790M with ADMET Profiling.
Raghunath Khedkar N, Sindkhedkar M, Joseph A. Raghunath Khedkar N, et al. Bioorg Chem. 2024 Feb;143:107027. doi: 10.1016/j.bioorg.2023.107027. Epub 2023 Dec 10. Bioorg Chem. 2024. PMID: 38096682
The ongoing research in cancer treatment underscores the significance of dual epidermal growth factor receptor (EGFR) kinase inhibitors targeting both mutant and wild-type variants. In this study, employing in silico fragment-based drug design (FBDD) and computational anal …
The ongoing research in cancer treatment underscores the significance of dual epidermal growth factor receptor (EGFR) kinase inhibito …
A novel mTOR inhibitor is efficacious in a murine model of colitis.
Bhonde MR, Gupte RD, Dadarkar SD, Jadhav MG, Tannu AA, Bhatt P, Bhatia DR, Desai NK, Deore V, Yewalkar N, Vishwakarma RA, Sharma S, Kumar S, Dagia NM. Bhonde MR, et al. Am J Physiol Gastrointest Liver Physiol. 2008 Dec;295(6):G1237-45. doi: 10.1152/ajpgi.90537.2008. Epub 2008 Oct 16. Am J Physiol Gastrointest Liver Physiol. 2008. PMID: 18927209 Free article.
Several compounds that possess antiproliferative properties and/or inhibit cytokine production exhibit a therapeutic effect in murine models of colitis. Mammalian target of rapamycin (mTOR), a protein kinase regulating cell proliferation, is implicated in colon carcinogene …
Several compounds that possess antiproliferative properties and/or inhibit cytokine production exhibit a therapeutic effect in murine models …
A preferential p110alpha/gamma PI3K inhibitor attenuates experimental inflammation by suppressing the production of proinflammatory mediators in a NF-kappaB-dependent manner.
Dagia NM, Agarwal G, Kamath DV, Chetrapal-Kunwar A, Gupte RD, Jadhav MG, Dadarkar SS, Trivedi J, Kulkarni-Almeida AA, Kharas F, Fonseca LC, Kumar S, Bhonde MR. Dagia NM, et al. Am J Physiol Cell Physiol. 2010 Apr;298(4):C929-41. doi: 10.1152/ajpcell.00461.2009. Epub 2010 Jan 20. Am J Physiol Cell Physiol. 2010. PMID: 20089935 Free article.
The production of proinflammatory cytokines is controlled at the gene level by the activity of transcription factors, such as NF-kappaB. Phosphatidylinositol 3-kinase (PI3K), a lipid kinase, is known to induce the activation of NF-kappaB. ...
The production of proinflammatory cytokines is controlled at the gene level by the activity of transcription factors, such as NF-kappaB. Pho …