A novel mTOR inhibitor is efficacious in a murine model of colitis.
Bhonde MR, Gupte RD, Dadarkar SD, Jadhav MG, Tannu AA, Bhatt P, Bhatia DR, Desai NK, Deore V, Yewalkar N, Vishwakarma RA, Sharma S, Kumar S, Dagia NM.
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Am J Physiol Gastrointest Liver Physiol. 2008 Dec;295(6):G1237-45. doi: 10.1152/ajpgi.90537.2008. Epub 2008 Oct 16.
Am J Physiol Gastrointest Liver Physiol. 2008.
PMID: 18927209
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Several compounds that possess antiproliferative properties and/or inhibit cytokine production exhibit a therapeutic effect in murine models of colitis. Mammalian target of rapamycin (mTOR), a protein kinase regulating cell proliferation, is implicated in colon carcinogene …
Several compounds that possess antiproliferative properties and/or inhibit cytokine production exhibit a therapeutic effect in murine models …