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Page 1
Inhibitory effects of the antiangiogenic agent TNP-470 on establishment and growth of hematogenous metastasis of human pancreatic carcinoma in SCID beige mice in vivo.
Kawarada Y, Ishikura H, Kishimoto T, Saito K, Takahashi T, Kato H, Yoshiki T. Kawarada Y, et al. Pancreas. 1997 Oct;15(3):251-7. doi: 10.1097/00006676-199710000-00006. Pancreas. 1997. PMID: 9336788
One million PCI-43 cells, a human pancreas carcinoma cell line, were injected into the spleen of SCID beige mice, then TNP-470 at 30 mg/kg was administered subcutaneously every other day. ...Suppression of proliferation and an increase in apoptosis were evident in metastat …
One million PCI-43 cells, a human pancreas carcinoma cell line, were injected into the spleen of SCID beige mice, then TNP-470 at 30 …
In vivo antitumor activity of Sindbis viral vectors.
Tseng JC, Levin B, Hirano T, Yee H, Pampeno C, Meruelo D. Tseng JC, et al. J Natl Cancer Inst. 2002 Dec 4;94(23):1790-802. doi: 10.1093/jnci/94.23.1790. J Natl Cancer Inst. 2002. PMID: 12464651
Apoptosis was analyzed by TUNEL (terminal deoxynucleotidyl transferase [TdT]-mediated dUTP nick end labeling) staining. C.B-17-SCID beige mice, which lack natural killer (NK) cells, were used to assess the importance of NK cells in antitumor efficacy of Sindbis vira …
Apoptosis was analyzed by TUNEL (terminal deoxynucleotidyl transferase [TdT]-mediated dUTP nick end labeling) staining. C.B-17-SCID …
A Pharmacological Strategy Using Stemofoline for more Efficacious Chemotherapeutic Treatments Against Human Multidrug Resistant Leukemic Cells.
Umsumarng S, Mapoung S, Yodkeeree S, Pyne SG, Limtrakul Dejkriengkraikul P. Umsumarng S, et al. Asian Pac J Cancer Prev. 2018 Dec 25;19(12):3533-3543. doi: 10.31557/APJCP.2018.19.12.3533. Asian Pac J Cancer Prev. 2018. PMID: 30583680 Free PMC article.
The combination treatment of 50 mg/kg of STF strongly enhanced the anti-tumor activity of DOX in SCID-beige mice bearing K562/Adr xenografts without additional toxicity when compared to the single treatment groups. ...
The combination treatment of 50 mg/kg of STF strongly enhanced the anti-tumor activity of DOX in SCID-beige mice bearing K562/Adr xen …
The Drosophila BEACH family protein, blue cheese, links lysosomal axon transport with motor neuron degeneration.
Lim A, Kraut R. Lim A, et al. J Neurosci. 2009 Jan 28;29(4):951-63. doi: 10.1523/JNEUROSCI.2582-08.2009. J Neurosci. 2009. PMID: 19176804 Free PMC article.
A role in lysosomal trafficking is suggested by the homology of Bchs with the vesicle trafficking-associated BEACH (Beige and Chediak-Higashi) domain protein family (Wang et al., 2002; De Lozanne, 2003) and by its genetic interaction with a lysosomal transport pathway (Sim …
A role in lysosomal trafficking is suggested by the homology of Bchs with the vesicle trafficking-associated BEACH (Beige and Chediak …
Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer.
Stephan S, Datta K, Wang E, Li J, Brekken RA, Parangi S, Thorpe PE, Mukhopadhyay D. Stephan S, et al. Clin Cancer Res. 2004 Oct 15;10(20):6993-7000. doi: 10.1158/1078-0432.CCR-04-0808. Clin Cancer Res. 2004. PMID: 15501979
EXPERIMENTAL DESIGN: Human pancreatic cancer AsPC-1 cells were orthotopically injected into severe combined immunodeficient/beige mice to evaluate primary tumor growth and liver metastasis after treatment with rapamycin alone or in combination with anti-vascular endothelia …
EXPERIMENTAL DESIGN: Human pancreatic cancer AsPC-1 cells were orthotopically injected into severe combined immunodeficient/beige mic …
Cyclosporine a mediates pathogenesis of aggressive cutaneous squamous cell carcinoma by augmenting epithelial-mesenchymal transition: role of TGFβ signaling pathway.
Walsh SB, Xu J, Xu H, Kurundkar AR, Maheshwari A, Grizzle WE, Timares L, Huang CC, Kopelovich L, Elmets CA, Athar M. Walsh SB, et al. Mol Carcinog. 2011 Jul;50(7):516-27. doi: 10.1002/mc.20744. Epub 2011 Feb 9. Mol Carcinog. 2011. PMID: 21308804 Free PMC article.
Similar results were obtained when these tumors were grown in SCID-beige mice or in immuno-competent mice inoculated with syngeinic tumor cells. ...
Similar results were obtained when these tumors were grown in SCID-beige mice or in immuno-competent mice inoculated with syngeinic t …
Aging of human epidermis: reversal of aging changes correlates with reversal of keratinocyte fas expression and apoptosis.
Gilhar A, Ullmann Y, Karry R, Shalaginov R, Assy B, Serafimovich S, Kalish RS. Gilhar A, et al. J Gerontol A Biol Sci Med Sci. 2004 May;59(5):411-5. doi: 10.1093/gerona/59.5.b411. J Gerontol A Biol Sci Med Sci. 2004. PMID: 15123749
Skin from aged participants (n = 14; mean 70.7 years), and young participants (n = 14; mean 23.4 years) was grafted to beige SCID mice, and epidermal thickness, proliferation (Ki-67 expression), apoptosis (TUNEL [Tdt-mediated dUTP nick end labeling] reaction below g …
Skin from aged participants (n = 14; mean 70.7 years), and young participants (n = 14; mean 23.4 years) was grafted to beige SCID mic …
NK cell activation and tumor infiltration are involved in the antitumor mechanism of Virulizin.
Cao MY, Lee Y, Feng N, Li H, Du C, Miao D, Li J, Lee V, Jin H, Wang M, Gu X, Wright JA, Young AH. Cao MY, et al. Cancer Immunol Immunother. 2005 Mar;54(3):229-42. doi: 10.1007/s00262-004-0582-0. Epub 2004 Sep 17. Cancer Immunol Immunother. 2005. PMID: 15378281 Free PMC article.
In addition, Virulizin resulted in an increase in the number of NK cells in the spleens, and NK cells isolated from the spleen exhibited increased cytotoxicity to tumor cells in vitro. In NK cell-deficient SCID-beige mice, the antitumor activity of Virulizin was compromise …
In addition, Virulizin resulted in an increase in the number of NK cells in the spleens, and NK cells isolated from the spleen exhibited inc …
Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma.
Christensen JG, Zou HY, Arango ME, Li Q, Lee JH, McDonnell SR, Yamazaki S, Alton GR, Mroczkowski B, Los G. Christensen JG, et al. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3314-22. doi: 10.1158/1535-7163.MCT-07-0365. Mol Cancer Ther. 2007. PMID: 18089725
The induction of apoptosis was confirmed using terminal deoxyribonucleotide transferase-mediated nick-end labeling and Annexin V staining (IC(50) values, 25-50 nmol/L). P.o. administration of PF-2341066 to severe combined immunodeficient-Beige mice bearing Karpas299 …
The induction of apoptosis was confirmed using terminal deoxyribonucleotide transferase-mediated nick-end labeling and Annexin V stai …
Suppression of angiogenesis, tumorigenicity, and metastasis by human prostate cancer cells engineered to produce interferon-beta.
Dong Z, Greene G, Pettaway C, Dinney CP, Eue I, Lu W, Bucana CD, Balbay MD, Bielenberg D, Fidler IJ. Dong Z, et al. Cancer Res. 1999 Feb 15;59(4):872-9. Cancer Res. 1999. PMID: 10029078
PC-3M-IFN-beta cells produced small tumors (3-5 mm in diameter) in nude mice treated with anti-asialo GM1 antibodies and in severe combined immunodeficient/Beige mice. Immunohistochemical staining revealed that PC-3M-IFN-beta tumors were homogeneously infiltrated by macrop …
PC-3M-IFN-beta cells produced small tumors (3-5 mm in diameter) in nude mice treated with anti-asialo GM1 antibodies and in severe combined …