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Year Number of Results
1996 1
2003 1
2005 1
2006 1
2008 1
2009 1
2010 2
2011 2
2012 4
2013 2
2014 5
2015 4
2016 8
2017 8
2018 15
2019 12
2020 10
2021 12
2022 12
2023 8
2024 6

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101 results

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Page 1
Receptor tyrosine kinase activation: From the ligand perspective.
Trenker R, Jura N. Trenker R, et al. Curr Opin Cell Biol. 2020 Apr;63:174-185. doi: 10.1016/j.ceb.2020.01.016. Epub 2020 Feb 27. Curr Opin Cell Biol. 2020. PMID: 32114309 Free PMC article. Review.
Receptor tyrosine kinases (RTKs) are single-span transmembrane receptors in which relatively conserved intracellular kinase domains are coupled to divergent extracellular modules. The extracellular domains initiate receptor signaling upon binding to either soluble o …
Receptor tyrosine kinases (RTKs) are single-span transmembrane receptors in which relatively conserved intracellular kinase domains a …
Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface.
Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N. Diwanji D, et al. Nature. 2021 Dec;600(7888):339-343. doi: 10.1038/s41586-021-04084-z. Epub 2021 Nov 10. Nature. 2021. PMID: 34759323 Free PMC article.
We show that the dimerization arm of NRG1beta-bound HER3 is unresolved because the apo HER2 monomer does not undergo a ligand-induced conformational change needed to establish a HER3 dimerization arm-binding pocket. In a structure of the oncogenic extracellular domain muta …
We show that the dimerization arm of NRG1beta-bound HER3 is unresolved because the apo HER2 monomer does not undergo a ligand-induced confor …
Quercetin induces lipid domain-dependent permeability.
Leite NB, Martins DB, Alvares DS, Cabrera MPDS. Leite NB, et al. Chem Phys Lipids. 2022 Jan;242:105160. doi: 10.1016/j.chemphyslip.2021.105160. Epub 2021 Nov 20. Chem Phys Lipids. 2022. PMID: 34808124 Free article.
Nevertheless, the presence of sphingomyelin in the ternary system led to a more heterogeneous bilayer with the formation of micrometric and probably also nanometric domains, which coalesce in the presence of quercetin. This observation together with increased permeability …
Nevertheless, the presence of sphingomyelin in the ternary system led to a more heterogeneous bilayer with the formation of micrometric and …
CTBP1 and CTBP2 mutations underpinning neurological disorders: a systematic review.
Acosta-Baena N, Tejada-Moreno JA, Arcos-Burgos M, Villegas-Lanau CA. Acosta-Baena N, et al. Neurogenetics. 2022 Oct;23(4):231-240. doi: 10.1007/s10048-022-00700-w. Epub 2022 Nov 4. Neurogenetics. 2022. PMID: 36331689 Free PMC article. Review.
These mutations were de novo in 13 cases and one case of maternal germinal mosaicism. Two variants are in the same domain of the protein: Pro-Leu-Asp-Leu-Ser (PLDLS) C terminal. Patients with these mutations exhibit a phenotype with intellectual disability, HADDTS s …
These mutations were de novo in 13 cases and one case of maternal germinal mosaicism. Two variants are in the same domain of the p …
Switching on BTK-One Domain at a Time.
Agnew C, Jura N. Agnew C, et al. Structure. 2017 Oct 3;25(10):1469-1470. doi: 10.1016/j.str.2017.09.012. Epub 2017 Oct 3. Structure. 2017. PMID: 28978404 Free article.
BTK kinase activity is controlled by multiple inhibitory domains, whose coordinated mechanism of action is poorly understood. ...
BTK kinase activity is controlled by multiple inhibitory domains, whose coordinated mechanism of action is poorly understood. ...
Structural Basis for the Non-catalytic Functions of Protein Kinases.
Kung JE, Jura N. Kung JE, et al. Structure. 2016 Jan 5;24(1):7-24. doi: 10.1016/j.str.2015.10.020. Structure. 2016. PMID: 26745528 Free PMC article. Review.
Protein kinases are known primarily for their ability to phosphorylate protein substrates, which constitutes an essential biological process. Recently, compelling evidence has accumulated that the functions of many protein kinases extend beyond phosphorylatio …
Protein kinases are known primarily for their ability to phosphorylate protein substrates, which constitutes an essential biol …
Biomolecular Condensates: Structure, Functions, Methods of Research.
Gorsheneva NA, Sopova JV, Azarov VV, Grizel AV, Rubel AA. Gorsheneva NA, et al. Biochemistry (Mosc). 2024 Jan;89(Suppl 1):S205-S223. doi: 10.1134/S0006297924140116. Biochemistry (Mosc). 2024. PMID: 38621751 Review.
In this review, we discuss variety of biomolecular condensates and their functions in live cells, describe their structure variants, highlight domain and primary sequence organization of the constituent proteins and nucleic acids. ...
In this review, we discuss variety of biomolecular condensates and their functions in live cells, describe their structure variants, highlig …
Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization.
Agnew C, Ayaz P, Kashima R, Loving HS, Ghatpande P, Kung JE, Underbakke ES, Shan Y, Shaw DE, Hata A, Jura N. Agnew C, et al. Nat Commun. 2021 Aug 16;12(1):4950. doi: 10.1038/s41467-021-25248-5. Nat Commun. 2021. PMID: 34400635 Free PMC article.
Upon ligand binding, bone morphogenetic protein (BMP) receptors form active tetrameric complexes, comprised of two type I and two type II receptors, which then transmit signals to SMAD proteins. ...Formation of this dimer is essential for ligand-induced receptor signaling …
Upon ligand binding, bone morphogenetic protein (BMP) receptors form active tetrameric complexes, comprised of two type I and two typ …
A Novel Interaction Between RAD23A/B and Y-family DNA Polymerases.
Ashton NW, Jaiswal N, Moreno NC, Semenova IV, D'Orlando DA, Latancia MT, McIntyre J, Woodgate R, Bezsonova I. Ashton NW, et al. J Mol Biol. 2023 Dec 15;435(24):168353. doi: 10.1016/j.jmb.2023.168353. Epub 2023 Nov 5. J Mol Biol. 2023. PMID: 37935254 Free PMC article.
We initially focus on the interaction between RAD23A and Pol iota, and through a series of biochemical, cell-based, and structural assays, find that the RAD23A ubiquitin-binding domains (UBA1 and UBA2) interact with separate sites within the Pol iota catalytic domain …
We initially focus on the interaction between RAD23A and Pol iota, and through a series of biochemical, cell-based, and structural assays, f …
Cholesterol and its derivatives in Sonic Hedgehog signaling and cancer.
Riobo NA. Riobo NA. Curr Opin Pharmacol. 2012 Dec;12(6):736-41. doi: 10.1016/j.coph.2012.07.002. Epub 2012 Jul 23. Curr Opin Pharmacol. 2012. PMID: 22832232 Free PMC article. Review.
Cholesterol and related lipids are intricately linked to HH signaling: from the role of cholesterol in HH biosynthesis to the modulation of HH signal reception and transduction by other sterols, passing by the phylogenetic relationships among many components of the HH pathway tha …
Cholesterol and related lipids are intricately linked to HH signaling: from the role of cholesterol in HH biosynthesis to the modulation of …
101 results