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1986 1
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2007 3
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2010 3
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2012 4
2013 2
2014 1
2015 2
2017 5
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2019 5
2020 10
2021 6
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2023 12
2024 6

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72 results

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Page 1
IL-6 promotes metastasis of non-small-cell lung cancer by up-regulating TIM-4 via NF-κB.
Liu W, Wang H, Bai F, Ding L, Huang Y, Lu C, Chen S, Li C, Yue X, Liang X, Ma C, Xu L, Gao L. Liu W, et al. Cell Prolif. 2020 Mar;53(3):e12776. doi: 10.1111/cpr.12776. Epub 2020 Feb 5. Cell Prolif. 2020. PMID: 32020709 Free PMC article.
OBJECTIVES: Interleukin-6 (IL-6) is critical for the development of non-small-cell lung cancer (NSCLC). Recently, we identified T-cell immunoglobulin domain and mucin domain 4 (TIM-4) as a new pro-growth player in NSCLC progression. ...
OBJECTIVES: Interleukin-6 (IL-6) is critical for the development of non-small-cell lung cancer (NSCLC). Recently, we identified T-cell immun …
REGgamma Mitigates Radiation-Induced Enteritis by Preserving Mucin Secretion and Sustaining Microbiome Homeostasis.
Zhu X, Li Y, Tian X, Jing Y, Wang Z, Yue L, Li J, Wu L, Zhou X, Yu Z, Zhang Y, Guan F, Yang M, Zhang B. Zhu X, et al. Am J Pathol. 2024 Jun;194(6):975-988. doi: 10.1016/j.ajpath.2024.02.008. Epub 2024 Feb 27. Am J Pathol. 2024. PMID: 38423356
Interestingly, although administration of broad-spectrum antibiotics did not alter the goblet cell numbers or mucin 2 (MUC2) secretion, it effectively attenuated inflammation levels in the ileum of irradiated REGgamma absent mice, bringing them down to the wild-type levels …
Interestingly, although administration of broad-spectrum antibiotics did not alter the goblet cell numbers or mucin 2 (MUC2) secretio …
Identification of a small-molecule Tim-3 inhibitor to potentiate T cell-mediated antitumor immunotherapy in preclinical mouse models.
Ma S, Tian Y, Peng J, Chen C, Peng X, Zhao F, Li Z, Li M, Zhao F, Sheng X, Zong R, Li Y, Zhang J, Yu M, Zhu Q, Tian X, Li Y, Neckenig MR, Liu H, Zhan P, Yue X, Wu Z, Gao L, Liang X, Liu X, Li C, Ma C. Ma S, et al. Sci Transl Med. 2023 Nov 15;15(722):eadg6752. doi: 10.1126/scitranslmed.adg6752. Epub 2023 Nov 15. Sci Transl Med. 2023. PMID: 37967204
T cell immunoglobulin and mucin-containing molecule 3 (Tim-3), expressed in dysfunctional and exhausted T cells, has been widely acknowledged as a promising immune checkpoint target for tumor immunotherapy. ...
T cell immunoglobulin and mucin-containing molecule 3 (Tim-3), expressed in dysfunctional and exhausted T cells, has been widely ackn …
Deciphering Protein O-GalNAcylation: Method Development and Disease Implication.
Yue S, Wang X, Ge W, Li J, Yang C, Zhou Z, Zhang P, Yang X, Xiao W, Yang S. Yue S, et al. ACS Omega. 2023 May 24;8(22):19223-19236. doi: 10.1021/acsomega.3c01653. eCollection 2023 Jun 6. ACS Omega. 2023. PMID: 37305274 Free PMC article. Review.
Mucin-type O-glycosylation is an important protein post-translational modification that is abundantly expressed on cell surface proteins. ...Dysregulation of mucin O-glycosylation may impair mucosal protection against pathogens that can invade cells to trigger infec …
Mucin-type O-glycosylation is an important protein post-translational modification that is abundantly expressed on cell surface prote …
Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages.
Wang Y, Wang Y, Ding L, Ren X, Wang B, Wang L, Zhao S, Yue X, Wu Z, Li C, Liang X, Ma C, Gao L. Wang Y, et al. Cell Rep. 2022 Nov 29;41(9):111738. doi: 10.1016/j.celrep.2022.111738. Cell Rep. 2022. PMID: 36450259 Free article.
Intervention of host cholesterol homeostasis has emerged as a promising strategy for antiviral therapy. T cell immunoglobulin and mucin domain-containing molecule 4 (Tim-4) is indispensable in maintaining the homeostasis of macrophages. ...
Intervention of host cholesterol homeostasis has emerged as a promising strategy for antiviral therapy. T cell immunoglobulin and mucin …
A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts.
Zindl CL, Witte SJ, Laufer VA, Gao M, Yue Z, Janowski KM, Cai B, Frey BF, Silberger DJ, Harbour SN, Singer JR, Turner H, Lund FE, Vallance BA, Rosenberg AF, Schoeb TR, Chen JY, Hatton RD, Weaver CT. Zindl CL, et al. Immunity. 2022 Mar 8;55(3):494-511.e11. doi: 10.1016/j.immuni.2022.02.003. Immunity. 2022. PMID: 35263568 Free PMC article.
This reflected a requirement for T cell-derived IL-22 for the expression of a host-protective transcriptomic program that included AMPs, neutrophil-recruiting chemokines, and mucin-related molecules, and it restricted IFNgamma-induced proinflammatory genes. ...
This reflected a requirement for T cell-derived IL-22 for the expression of a host-protective transcriptomic program that included AMPs, neu …
Akkermansia muciniphila plays critical roles in host health.
Zhao Q, Yu J, Hao Y, Zhou H, Hu Y, Zhang C, Zheng H, Wang X, Zeng F, Hu J, Gu L, Wang Z, Zhao F, Yue C, Zhou P, Zhang H, Huang N, Wu W, Zhou Y, Li J. Zhao Q, et al. Crit Rev Microbiol. 2023 Feb;49(1):82-100. doi: 10.1080/1040841X.2022.2037506. Epub 2022 May 21. Crit Rev Microbiol. 2023. PMID: 35603929 Review.
Akkermansia muciniphila, an intestinal microorganism, belongs to Verrucomicrobia, one of the most abundant microorganisms in the mammalian gut. It is a mucin-degrading bacterium that can colonise intestines of mammals such as humans and mice by utilising mucin as th …
Akkermansia muciniphila, an intestinal microorganism, belongs to Verrucomicrobia, one of the most abundant microorganisms in the mammalian g …
Cystic Neoplasms of the Pancreas: Differential Diagnosis and Radiology Correlation.
Hu F, Hu Y, Wang D, Ma X, Yue Y, Tang W, Liu W, Wu P, Peng W, Tong T. Hu F, et al. Front Oncol. 2022 Mar 1;12:860740. doi: 10.3389/fonc.2022.860740. eCollection 2022. Front Oncol. 2022. PMID: 35299739 Free PMC article. Review.
., solid pseudopapillary neoplasms (SPNs), intraductal papillary mucinous neoplasms (IPMNs), and mucinous cystic neoplasms (MCNs)]. ...
., solid pseudopapillary neoplasms (SPNs), intraductal papillary mucinous neoplasms (IPMNs), and mucinous cystic neoplasms (MC …
Targeting MUC15 Protein in Cancer: Molecular Mechanisms and Therapeutic Perspectives.
Zhang S, Zhang W, Xiao Y, Qin T, Yue Y, Qian W, Shen X, Ma Q, Wang Z. Zhang S, et al. Curr Cancer Drug Targets. 2020;20(9):647-653. doi: 10.2174/1568009620666200601140639. Curr Cancer Drug Targets. 2020. PMID: 32479243 Review.
MUC15, a member of the mucin family, is a heavily glycosylated transmembrane protein with the primary functions of lubricating surfaces, establishing a selective molecular barrier at the epithelium and mediating signal transduction. ...
MUC15, a member of the mucin family, is a heavily glycosylated transmembrane protein with the primary functions of lubricating surfac …
TIM-4 orchestrates mitochondrial homeostasis to promote lung cancer progression via ANXA2/PI3K/AKT/OPA1 axis.
Wang Y, Wang Y, Liu W, Ding L, Zhang X, Wang B, Tong Z, Yue X, Li C, Xu L, Wu Z, Liang X, Ma C, Gao L. Wang Y, et al. Cell Death Dis. 2023 Feb 20;14(2):141. doi: 10.1038/s41419-023-05678-3. Cell Death Dis. 2023. PMID: 36806050 Free PMC article.
Mitochondrial function and homeostasis are critical to the proliferation of lung cancer cells. T-cell immunoglobulin and mucin domain-containing molecule 4 (TIM-4) promotes the development and progression of lung cancer. ...
Mitochondrial function and homeostasis are critical to the proliferation of lung cancer cells. T-cell immunoglobulin and mucin domain …
72 results