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Year Number of Results
1967 1
1991 1
1992 2
1995 1
2000 1
2001 1
2002 3
2003 4
2004 4
2005 3
2006 4
2007 8
2008 10
2009 9
2010 12
2011 6
2012 12
2013 14
2014 12
2015 22
2016 19
2017 25
2018 16
2019 29
2020 29
2021 36
2022 38
2023 30
2024 13

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316 results

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Page 1
Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial.
Bartsch R, Berghoff AS, Furtner J, Marhold M, Bergen ES, Roider-Schur S, Starzer AM, Forstner H, Rottenmanner B, Dieckmann K, Bago-Horvath Z, Haslacher H, Widhalm G, Ilhan-Mutlu A, Minichsdorfer C, Fuereder T, Szekeres T, Oehler L, Gruenberger B, Singer CF, Weltermann A, Puhr R, Preusser M. Bartsch R, et al. Nat Med. 2022 Sep;28(9):1840-1847. doi: 10.1038/s41591-022-01935-8. Epub 2022 Aug 8. Nat Med. 2022. PMID: 35941372 Free PMC article. Clinical Trial.
Two patients (13.3%) had a complete intracranial response, nine (60%) had a partial intracranial response and three (20%) had stable disease as the best intracranial response, with a best overall intracranial response rate of 73.3% (95% confidential interval 48.1-89.1%), t …
Two patients (13.3%) had a complete intracranial response, nine (60%) had a partial intracranial response and three (20%) had stable …
Integrated multi-omics reveals anaplerotic rewiring in methylmalonyl-CoA mutase deficiency.
Forny P, Bonilla X, Lamparter D, Shao W, Plessl T, Frei C, Bingisser A, Goetze S, van Drogen A, Harshman K, Pedrioli PGA, Howald C, Poms M, Traversi F, Bürer C, Cherkaoui S, Morscher RJ, Simmons L, Forny M, Xenarios I, Aebersold R, Zamboni N, Rätsch G, Dermitzakis ET, Wollscheid B, Baumgartner MR, Froese DS. Forny P, et al. Nat Metab. 2023 Jan;5(1):80-95. doi: 10.1038/s42255-022-00720-8. Epub 2023 Jan 26. Nat Metab. 2023. PMID: 36717752 Free PMC article.
The relevance of these disturbances is evidenced by multi-organ metabolomics of a hemizygous Mmut mouse model as well as through identification of physical interactions between MMUT and glutamine anaplerotic enzymes. Using stable-isotope tracing, we find that treatment wit …
The relevance of these disturbances is evidenced by multi-organ metabolomics of a hemizygous Mmut mouse model as well as through identificat …
Genome maintenance meets mechanobiology.
Spegg V, Altmeyer M. Spegg V, et al. Chromosoma. 2024 Jan;133(1):15-36. doi: 10.1007/s00412-023-00807-5. Epub 2023 Aug 15. Chromosoma. 2024. PMID: 37581649 Free PMC article. Review.
Genome stability is key for healthy cells in healthy organisms, and deregulated maintenance of genome integrity is a hallmark of aging and of age-associated diseases including cancer and neurodegeneration. To maintain a stable genome, genome surveillance and repair pathway …
Genome stability is key for healthy cells in healthy organisms, and deregulated maintenance of genome integrity is a hallmark of aging and o …
Physiological Functions of Intracellular Protein Degradation.
McShane E, Selbach M. McShane E, et al. Annu Rev Cell Dev Biol. 2022 Oct 6;38:241-262. doi: 10.1146/annurev-cellbio-120420-091943. Epub 2022 May 19. Annu Rev Cell Dev Biol. 2022. PMID: 35587265 Review.
While cellular proteins were initially thought to be stable, research over the last decades has firmly established that intracellular protein degradation is an active and highly regulated process: Lysosomal, proteasomal, and mitochondrial degradation systems were identifie …
While cellular proteins were initially thought to be stable, research over the last decades has firmly established that intracellular …
Quantitative Comparison of Proteomes Using SILAC.
Deng J, Erdjument-Bromage H, Neubert TA. Deng J, et al. Curr Protoc Protein Sci. 2019 Feb;95(1):e74. doi: 10.1002/cpps.74. Epub 2018 Sep 20. Curr Protoc Protein Sci. 2019. PMID: 30238645 Free PMC article. Review.
Stable isotope labeling by amino acids in cell culture (SILAC) has become very popular as a quantitative proteomic method since it was firstly introduced by Matthias Mann's group in 2002. ...
Stable isotope labeling by amino acids in cell culture (SILAC) has become very popular as a quantitative proteomic method since it wa …
Toxin⁻Antitoxin Systems in Bacillus subtilis.
Brantl S, Müller P. Brantl S, et al. Toxins (Basel). 2019 May 9;11(5):262. doi: 10.3390/toxins11050262. Toxins (Basel). 2019. PMID: 31075979 Free PMC article. Review.
Toxin-antitoxin (TA) systems were originally discovered as plasmid maintenance systems in a multitude of free-living bacteria, but were afterwards found to also be widespread in bacterial chromosomes. TA loci comprise two genes, one coding for a stable toxin whose overexpr …
Toxin-antitoxin (TA) systems were originally discovered as plasmid maintenance systems in a multitude of free-living bacteria, but were afte …
Prognosis of patients with hepatocellular carcinoma treated with immunotherapy - development and validation of the CRAFITY score.
Scheiner B, Pomej K, Kirstein MM, Hucke F, Finkelmeier F, Waidmann O, Himmelsbach V, Schulze K, von Felden J, Fründt TW, Stadler M, Heinzl H, Shmanko K, Spahn S, Radu P, Siebenhüner AR, Mertens JC, Rahbari NN, Kütting F, Waldschmidt DT, Ebert MP, Teufel A, De Dosso S, Pinato DJ, Pressiani T, Meischl T, Balcar L, Müller C, Mandorfer M, Reiberger T, Trauner M, Personeni N, Rimassa L, Bitzer M, Trojan J, Weinmann A, Wege H, Dufour JF, Peck-Radosavljevic M, Vogel A, Pinter M. Scheiner B, et al. J Hepatol. 2022 Feb;76(2):353-363. doi: 10.1016/j.jhep.2021.09.035. Epub 2021 Oct 12. J Hepatol. 2022. PMID: 34648895 Free article.
Additionally, best radiological response (complete response/partial response/stable disease/progressive disease) was significantly better in patients with lower CRAFITY score (CRAFITY-low: 9%/20%/52%/20% vs. ...
Additionally, best radiological response (complete response/partial response/stable disease/progressive disease) was significantly be …
Robustness during Aging-Molecular Biological and Physiological Aspects.
Barth E, Sieber P, Stark H, Schuster S. Barth E, et al. Cells. 2020 Aug 8;9(8):1862. doi: 10.3390/cells9081862. Cells. 2020. PMID: 32784503 Free PMC article. Review.
However, there are certain aspects that remain surprisingly stable and keep the organism robust. Here, we present and discuss various properties of robust behavior during human and animal aging, including physiological and molecular biological features, such as the hematoc …
However, there are certain aspects that remain surprisingly stable and keep the organism robust. Here, we present and discuss various …
25th Annual Computational Neuroscience Meeting: CNS-2016.
Sharpee TO, Destexhe A, Kawato M, Sekulić V, Skinner FK, Wójcik DK, Chintaluri C, Cserpán D, Somogyvári Z, Kim JK, Kilpatrick ZP, Bennett MR, Josić K, Elices I, Arroyo D, Levi R, Rodriguez FB, Varona P, Hwang E, Kim B, Han HB, Kim T, McKenna JT, Brown RE, McCarley RW, Choi JH, Rankin J, Popp PO, Rinzel J, Tabas A, Rupp A, Balaguer-Ballester E, Maturana MI, Grayden DB, Cloherty SL, Kameneva T, Ibbotson MR, Meffin H, Koren V, Lochmann T, Dragoi V, Obermayer K, Psarrou M, Schilstra M, Davey N, Torben-Nielsen B, Steuber V, Ju H, Yu J, Hines ML, Chen L, Yu Y, Kim J, Leahy W, Shlizerman E, Birgiolas J, Gerkin RC, Crook SM, Viriyopase A, Memmesheimer RM, Gielen S, Dabaghian Y, DeVito J, Perotti L, Kim AJ, Fenk LM, Cheng C, Maimon G, Zhao C, Widmer Y, Sprecher S, Senn W, Halnes G, Mäki-Marttunen T, Keller D, Pettersen KH, Andreassen OA, Einevoll GT, Yamada Y, Steyn-Ross ML, Alistair Steyn-Ross D, Mejias JF, Murray JD, Kennedy H, Wang XJ, Kruscha A, Grewe J, Benda J, Lindner B, Badel L, Ohta K, Tsuchimoto Y, Kazama H, Kahng B, Tam ND, Pollonini L, Zouridakis G, Soh J, Kim D, Yoo M, Palmer SE, Culmone V, Bojak I, Ferrario A, Merrison-Hort R, Borisyuk R, Kim CS, Tezuka T, Joo P, Rho YA, Burt… See abstract for full author list ➔ Sharpee TO, et al. BMC Neurosci. 2016 Aug 18;17 Suppl 1(Suppl 1):54. doi: 10.1186/s12868-016-0283-6. BMC Neurosci. 2016. PMID: 27534393 Free PMC article.
Schiff P68 STDP improves speech recognition capabilities in spiking recurrent circuits parameterized via differential evolution Markov Chain Monte Carlo Richard Veale, Matthias Scheutz P69 Bidirectional transformation between dominant cortical neural activities and phase d …
Schiff P68 STDP improves speech recognition capabilities in spiking recurrent circuits parameterized via differential evolution Markov Chain …
Stable and reusable Ni-based nanoparticles for general and selective hydrogenation of nitriles to amines.
Ma Z, Chandrashekhar VG, Zhou B, Alenad AM, Rockstroh N, Bartling S, Beller M, Jagadeesh RV. Ma Z, et al. Chem Sci. 2022 Sep 2;13(36):10914-10922. doi: 10.1039/d2sc02961h. eCollection 2022 Sep 21. Chem Sci. 2022. PMID: 36320707 Free PMC article.
By calcination of a template material generated from Ni(ii)nitrate and colloidal silica under air and subsequent reduction in the presence of molecular hydrogen the optimal catalyst is prepared. The prepared supported nanoparticles are stable, can be conveniently used and …
By calcination of a template material generated from Ni(ii)nitrate and colloidal silica under air and subsequent reduction in the presence o …
316 results