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Targeting DNA methylation with small molecules: what's next?
Erdmann A, Halby L, Fahy J, Arimondo PB. Erdmann A, et al. J Med Chem. 2015 Mar 26;58(6):2569-83. doi: 10.1021/jm500843d. Epub 2014 Dec 4. J Med Chem. 2015. PMID: 25406944 Review.
DNA methylation is a mammalian epigenetic mark that is involved in defining where and when genes are expressed, both in normal cells and in the context of diseases. ...
DNA methylation is a mammalian epigenetic mark that is involved in defining where and when genes are expressed, both in normal cells …
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19.
ISARIC Clinical Characterization Group; Garcia-Gallo E, Merson L, Kennon K, Kelly S, Citarella BW, Fryer DV, Shrapnel S, Lee J, Duque S, Fuentes YV, Balan V, Smith S, Wei J, Gonçalves BP, Russell CD, Sigfrid L, Dagens A, Olliaro PL, Baruch J, Kartsonaki C, Dunning J, Rojek A, Rashan A, Beane A, Murthy S, Reyes LF. ISARIC Clinical Characterization Group, et al. Sci Data. 2022 Jul 30;9(1):454. doi: 10.1038/s41597-022-01534-9. Sci Data. 2022. PMID: 35908040 Free PMC article.
Incidence of central venous catheter hub contamination.
Holroyd JL, Vasilopoulos T, Rice MJ, Rand KH, Fahy BG. Holroyd JL, et al. J Crit Care. 2017 Jun;39:162-168. doi: 10.1016/j.jcrc.2017.02.035. Epub 2017 Feb 27. J Crit Care. 2017. PMID: 28259730
Midwifery students experience of teamwork projects involving mark-related peer feedback.
Hastie CR, Fahy KM, Parratt JA, Grace S. Hastie CR, et al. Women Birth. 2016 Jun;29(3):252-9. doi: 10.1016/j.wombi.2015.11.008. Epub 2015 Dec 23. Women Birth. 2016. PMID: 26725516
AIM: To report on students' experiences of engaging in team based assignments which involved mark-related peer feedback. METHODS: Stories of midwifery students' experiences were collected from 17 participants across the three years of the degree. ...
AIM: To report on students' experiences of engaging in team based assignments which involved mark-related peer feedback. METHODS: Sto …
IL1RL1 asthma risk variants regulate airway type 2 inflammation.
Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, Lachowicz-Scroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay MA, Sheldon RT, Peters MC, Nocka KH, Fahy JV, Seibold MA. Gordon ED, et al. JCI Insight. 2016 Sep 8;1(14):e87871. doi: 10.1172/jci.insight.87871. JCI Insight. 2016. PMID: 27699235 Free PMC article.
We find that two single nucleotide polymorphisms (SNPs) in IL1RL1 - rs1420101 and rs11685480 - are strongly associated with plasma sST2 levels, though neither is an expression quantitative trait locus (eQTL) in whole blood. Rather, rs1420101 and rs11685480 mark eQTLs in ai …
We find that two single nucleotide polymorphisms (SNPs) in IL1RL1 - rs1420101 and rs11685480 - are strongly associated with plasma sST2 leve …
Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma.
Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Fajt ML, Wenzel SE, Israel E, Levy BD, Fahy JV. Lachowicz-Scroggins ME, et al. Am J Respir Crit Care Med. 2019 May 1;199(9):1076-1085. doi: 10.1164/rccm.201810-1869OC. Am J Respir Crit Care Med. 2019. PMID: 30888839 Free PMC article.
Conclusions: High extracellular DNA concentrations in sputum mark a subset of patients with more severe asthma who have NETs and markers of inflammasome activation in their airways....
Conclusions: High extracellular DNA concentrations in sputum mark a subset of patients with more severe asthma who have NETs and mark …