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Year Number of Results
1989 1
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1998 1
2003 5
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2006 6
2007 1
2008 3
2009 4
2010 1
2011 2
2012 1
2013 1
2014 2
2015 5
2016 3
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2018 3
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2020 3
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2023 4
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57 results

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Page 1
Targeted prodrug approaches for hormone refractory prostate cancer.
Aloysius H, Hu L. Aloysius H, et al. Med Res Rev. 2015 May;35(3):554-85. doi: 10.1002/med.21333. Epub 2014 Dec 22. Med Res Rev. 2015. PMID: 25529338 Review.
In order to improve the tumor selectivity of chemotherapeutics, various targeted prodrug approaches have been explored. Antibody-directed enzyme prodrug therapy (ADEPT) and gene-directed enzyme prodrug therapy (GDEPT) strategies leverage tumor-specific antige …
In order to improve the tumor selectivity of chemotherapeutics, various targeted prodrug approaches have been explored. Antibody-dire …
Pharmacology of ifosfamide.
Furlanut M, Franceschi L. Furlanut M, et al. Oncology. 2003;65 Suppl 2:2-6. doi: 10.1159/000073350. Oncology. 2003. PMID: 14586139 Review.
It is an oxazaphosphorine derivative with a structural formula similar to that of cyclophosphamide. As a prodrug it requires activation in the liver by a cytochrome mixed-function oxidase system. ...
It is an oxazaphosphorine derivative with a structural formula similar to that of cyclophosphamide. As a prodrug it requires activati …
Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system.
Lee JB, Zgair A, Malec J, Kim TH, Kim MG, Ali J, Qin C, Feng W, Chiang M, Gao X, Voronin G, Garces AE, Lau CL, Chan TH, Hume A, McIntosh TM, Soukarieh F, Al-Hayali M, Cipolla E, Collins HM, Heery DM, Shin BS, Yoo SD, Kagan L, Stocks MJ, Bradshaw TD, Fischer PM, Gershkovich P. Lee JB, et al. J Control Release. 2018 Sep 28;286:10-19. doi: 10.1016/j.jconrel.2018.07.022. Epub 2018 Jul 18. J Control Release. 2018. PMID: 30016732 Free PMC article.
Most of the approaches previously adopted were based on very bulky prodrug moieties such as those mimicking triglycerides (TG). We now report a study in which a lipophilic prodrug approach was used to efficiently deliver bexarotene (BEX) and retinoic acid (RA) to th …
Most of the approaches previously adopted were based on very bulky prodrug moieties such as those mimicking triglycerides (TG). We no …
Multifaceted Beneficial Effects of Erdosteine: More than a Mucolytic Agent.
Cazzola M, Page C, Rogliani P, Calzetta L, Matera MG. Cazzola M, et al. Drugs. 2020 Nov;80(17):1799-1809. doi: 10.1007/s40265-020-01412-x. Drugs. 2020. PMID: 33025535 Free PMC article. Review.
It belongs to the thiol-based family of drugs that are known to also possess potentially important antioxidant and anti-inflammatory properties, and exhibit antibacterial activity against a variety of medically important bacterial species. Erdosteine is a prodrug that is m …
It belongs to the thiol-based family of drugs that are known to also possess potentially important antioxidant and anti-inflammatory propert …
The Concept of an Ideal Antibiotic: Implications for Drug Design.
Gajdács M. Gajdács M. Molecules. 2019 Mar 3;24(5):892. doi: 10.3390/molecules24050892. Molecules. 2019. PMID: 30832456 Free PMC article. Review.
Based on 150 references, the aim of this review is to summarize current advances regarding the challenges of antibiotic drug discovery and the specific attributes of an ideal antibacterial drug (a prodrug or generally reactive compound with no specific target, broad-spectr …
Based on 150 references, the aim of this review is to summarize current advances regarding the challenges of antibiotic drug discovery and t …
Recent trends in targeted anticancer prodrug and conjugate design.
Singh Y, Palombo M, Sinko PJ. Singh Y, et al. Curr Med Chem. 2008;15(18):1802-26. doi: 10.2174/092986708785132997. Curr Med Chem. 2008. PMID: 18691040 Free PMC article. Review.
Classical prodrug and conjugate design have focused on the development of prodrugs that can overcome physicochemical (e.g., solubility, chemical instability) or biopharmaceutical problems (e.g., bioavailability, toxicity) associated with common anticancer drugs. The …
Classical prodrug and conjugate design have focused on the development of prodrugs that can overcome physicochemical (e.g., so …
5-Fluorouracil Conversion Pathway Mutations in Gastric Cancer.
Biagioni A, Staderini F, Peri S, Versienti G, Schiavone N, Cianchi F, Papucci L, Magnelli L. Biagioni A, et al. Biology (Basel). 2020 Sep 2;9(9):265. doi: 10.3390/biology9090265. Biology (Basel). 2020. PMID: 32887417 Free PMC article.
We demonstrated that mutations in such ways were associated with a poor prognosis and reduced overall survival, often caused by a deletion in the TYMP gene and amplification in TYMS. The use of prodrugs and dihydropyrimidine dehydrogenase (DPD) inhibitors, which normally c …
We demonstrated that mutations in such ways were associated with a poor prognosis and reduced overall survival, often caused by a deletion i …
Prodrug and conjugate drug delivery strategies for improving HIV/AIDS therapy.
Palombo MS, Singh Y, Sinko PJ. Palombo MS, et al. J Drug Deliv Sci Technol. 2009;19(1):3-14. doi: 10.1016/s1773-2247(09)50001-9. J Drug Deliv Sci Technol. 2009. PMID: 20717488 Free PMC article.
HIV attacks host immune cells namely macrophages and CD4(+)T-cells and sequesters itself into sanctuary and reservoir sites such as the lymphoid tissues, testes, and brain. Initial drug delivery efforts with prodrugs and drug conjugates focused on improving the physicochem …
HIV attacks host immune cells namely macrophages and CD4(+)T-cells and sequesters itself into sanctuary and reservoir sites such as the lymp …
Breast intraductal nanoformulations for treating ductal carcinoma in situ II: Dose de-escalation using a slow releasing/slow bioconverting prodrug strategy.
Al-Zubaydi F, Gao D, Kakkar D, Li S, Holloway J, Szekely Z, Chan N, Kumar S, Sabaawy HE, Love S, Sinko PJ. Al-Zubaydi F, et al. Drug Deliv Transl Res. 2022 Jan;12(1):240-256. doi: 10.1007/s13346-021-00903-y. Epub 2021 Feb 15. Drug Deliv Transl Res. 2022. PMID: 33590464
Direct esterification CPDs were not sufficiently stable so self-immolative CPDs were formulated in NSs and NPs. Prodrug release was evaluated from poly(lactic-co-glycolic acid) NPs, and CPD4 demonstrated the slowest release rate with the rank order of CPD2 (R = methyl) &gt …
Direct esterification CPDs were not sufficiently stable so self-immolative CPDs were formulated in NSs and NPs. Prodrug release was e …
Enhancing Pt(IV) Complexes' Anticancer Activity upon Encapsulation in Stimuli-Responsive Nanocages.
Sancho-Albero M, Facchetti G, Panini N, Meroni M, Bello E, Rimoldi I, Zucchetti M, Frapolli R, De Cola L. Sancho-Albero M, et al. Adv Healthc Mater. 2023 Jul;12(17):e2202932. doi: 10.1002/adhm.202202932. Epub 2023 Mar 28. Adv Healthc Mater. 2023. PMID: 36908188 Free article.
Herein, a strategy is presented to stabilize, transport, and intracellularly release a platinum(IV) (Pt(IV) ) prodrug using a breakable nanocarrier. Its reduction, and therefore activation as an anticancer drug, is promoted by the presence of glutathione in neoplastic cell …
Herein, a strategy is presented to stabilize, transport, and intracellularly release a platinum(IV) (Pt(IV) ) prodrug using a breakab …
57 results