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Intranasal Insulin for Alzheimer's Disease.
Hallschmid M. Hallschmid M. CNS Drugs. 2021 Jan;35(1):21-37. doi: 10.1007/s40263-020-00781-x. Epub 2021 Jan 30. CNS Drugs. 2021. PMID: 33515428 Free PMC article. Review.
Brain insulin signaling contributes to memory function and might be a viable target in the prevention and treatment of memory impairments including Alzheimer's disease. This short narrative review explores the potential of central nervous system (CNS) insulin …
Brain insulin signaling contributes to memory function and might be a viable target in the prevention and treatment of memory impairments in …
Olfactory Training.
Kronenbuerger M, Pilgramm M. Kronenbuerger M, et al. 2022 Oct 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2022 Oct 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 33620818 Free Books & Documents.
Furthermore, impaired olfaction may be a warning sign for common neurodegenerative disorders, such as Alzheimer's dementia and Parkinson disease. The most common causes of olfactory decline are sinonasal disease, viral infection, and nasofacial trauma. …
Furthermore, impaired olfaction may be a warning sign for common neurodegenerative disorders, such as Alzheimer's dementia and …
Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis.
Bridel C, van Wieringen WN, Zetterberg H, Tijms BM, Teunissen CE; and the NFL Group; Alvarez-Cermeño JC, Andreasson U, Axelsson M, Bäckström DC, Bartos A, Bjerke M, Blennow K, Boxer A, Brundin L, Burman J, Christensen T, Fialová L, Forsgren L, Frederiksen JL, Gisslén M, Gray E, Gunnarsson M, Hall S, Hansson O, Herbert MK, Jakobsson J, Jessen-Krut J, Janelidze S, Johannsson G, Jonsson M, Kappos L, Khademi M, Khalil M, Kuhle J, Landén M, Leinonen V, Logroscino G, Lu CH, Lycke J, Magdalinou NK, Malaspina A, Mattsson N, Meeter LH, Mehta SR, Modvig S, Olsson T, Paterson RW, Pérez-Santiago J, Piehl F, Pijnenburg YAL, Pyykkö OT, Ragnarsson O, Rojas JC, Romme Christensen J, Sandberg L, Scherling CS, Schott JM, Sellebjerg FT, Simone IL, Skillbäck T, Stilund M, Sundström P, Svenningsson A, Tortelli R, Tortorella C, Trentini A, Troiano M, Turner MR, van Swieten JC, Vågberg M, Verbeek MM, Villar LM, Visser PJ, Wallin A, Weiss A, Wikkelsø C, Wild EJ. Bridel C, et al. JAMA Neurol. 2019 Sep 1;76(9):1035-1048. doi: 10.1001/jamaneurol.2019.1534. JAMA Neurol. 2019. PMID: 31206160 Free PMC article.
Highest levels were observed in cognitively impaired HIV-positive individuals (iHIV), amyotrophic lateral sclerosis, frontotemporal dementia (FTD), and Huntington disease. In 33.3% of diagnoses, including HC, multiple sclerosis, Alzheimer disease (AD), and Pa …
Highest levels were observed in cognitively impaired HIV-positive individuals (iHIV), amyotrophic lateral sclerosis, frontotemporal dementia …
Regulatory T cells decrease C3-positive reactive astrocytes in Alzheimer-like pathology.
Stym-Popper G, Matta K, Chaigneau T, Rupra R, Demetriou A, Fouquet S, Dansokho C, Toly-Ndour C, Dorothée G. Stym-Popper G, et al. J Neuroinflammation. 2023 Mar 8;20(1):64. doi: 10.1186/s12974-023-02702-3. J Neuroinflammation. 2023. PMID: 36890536 Free PMC article.
BACKGROUND: Increasing evidence supports a key role for peripheral immune processes in the pathophysiology of Alzheimer's disease (AD), highlighting an intricate interplay between brain resident glial cells and both innate and adaptive peripheral immune effec …
BACKGROUND: Increasing evidence supports a key role for peripheral immune processes in the pathophysiology of Alzheimer's d …
Transcranial direct current stimulation as an additional treatment to selective serotonin reuptake inhibitors in adults with major depressive disorder in Germany (DepressionDC): a triple-blind, randomised, sham-controlled, multicentre trial.
Burkhardt G, Kumpf U, Crispin A, Goerigk S, Andre E, Plewnia C, Brendel B, Fallgatter A, Langguth B, Abdelnaim M, Hebel T, Normann C, Frase L, Zwanzger P, Diemer J, Kammer T, Schönfeldt-Lecuona C, Kamp D, Bajbouj M, Behler N, Wilkening A, Nenov-Matt T, Dechantsreiter E, Keeser D, Bulubas L, Palm U, Blankenstein C, Mansmann U, Falkai P, Brunoni AR, Hasan A, Padberg F. Burkhardt G, et al. Lancet. 2023 Aug 12;402(10401):545-554. doi: 10.1016/S0140-6736(23)00640-2. Epub 2023 Jul 3. Lancet. 2023. PMID: 37414064
Converging roles of PSENEN/PEN2 and CLN3 in the autophagy-lysosome system.
Klein M, Kaleem A, Oetjen S, Wünkhaus D, Binkle L, Schilling S, Gjorgjieva M, Scholz R, Gruber-Schoffnegger D, Storch S, Kins S, Drewes G, Hoffmeister-Ullerich S, Kuhl D, Hermey G. Klein M, et al. Autophagy. 2022 Sep;18(9):2068-2085. doi: 10.1080/15548627.2021.2016232. Epub 2021 Dec 29. Autophagy. 2022. PMID: 34964690 Free PMC article.
Mutations in components of the gamma-secretase underlie familial Alzheimer disease. In addition to its proteolytic activity, supplementary, gamma-secretase independent, functions in the macroautophagy/autophagy-lysosome system have been proposed. ...Our study strong …
Mutations in components of the gamma-secretase underlie familial Alzheimer disease. In addition to its proteolytic activity, s …
[Molecular genetic markers of Alzheimer dementia].
Németh A, Urbanics K, Tariska P, Kramer J, Füst G, Dinya E, Abel T, Romics L, Pados G, Manfred H, et al. Németh A, et al. Orv Hetil. 1995 Sep 3;136(36):1931-5. Orv Hetil. 1995. PMID: 7675432 Review. Hungarian.
Alzheimer's dementia (AD) is a progressive neurodegenerative disease which is one of the most common forms of dementia in the above 65 years old age group. ...However, definitive diagnosis is proved only by neurohistological findings. The etiology of the d …
Alzheimer's dementia (AD) is a progressive neurodegenerative disease which is one of the most common forms of dementia …
A novel process driving Alzheimer's disease validated in a mouse model: Therapeutic potential.
Greenfield SA, Cole GM, Coen CW, Frautschy S, Singh RP, Mekkittikul M, Garcia-Ratés S, Morrill P, Hollings O, Passmore M, Hasan S, Carty N, Bison S, Piccoli L, Carletti R, Tacconi S, Chalidou A, Pedercini M, Kroecher T, Astner H, Gerrard PA. Greenfield SA, et al. Alzheimers Dement (N Y). 2022 Apr 5;8(1):e12274. doi: 10.1002/trc2.12274. eCollection 2022. Alzheimers Dement (N Y). 2022. PMID: 35415206 Free PMC article.
INTRODUCTION: The neuronal mechanism driving Alzheimer's disease (AD) is incompletely understood. METHODS: Immunohistochemistry, pharmacology, biochemistry, and behavioral testing are employed in two pathological contexts-AD and a transgenic mouse model-to in …
INTRODUCTION: The neuronal mechanism driving Alzheimer's disease (AD) is incompletely understood. METHODS: Immunohistoc …
Quantitative EEG in Alzheimer's disease: cognitive state, resting state and association with disease severity.
Garn H, Waser M, Deistler M, Schmidt R, Dal-Bianco P, Ransmayr G, Zeitlhofer J, Schmidt H, Seiler S, Sanin G, Caravias G, Santer P, Grossegger D, Fruehwirt W, Benke T. Garn H, et al. Int J Psychophysiol. 2014 Sep;93(3):390-7. doi: 10.1016/j.ijpsycho.2014.06.003. Epub 2014 Jun 14. Int J Psychophysiol. 2014. PMID: 24933410
BACKGROUND: Quantitative electroencephalogram (qEEG) recorded during cognitive tasks has been shown to differentiate between patients with Alzheimer's disease (AD) and healthy individuals. However, the association between various qEEG markers recorded during …
BACKGROUND: Quantitative electroencephalogram (qEEG) recorded during cognitive tasks has been shown to differentiate between patients with …
17 results