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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1952 1
1956 1
1960 1
1964 1
1968 1
1969 2
1970 3
1971 6
1972 34
1973 63
1974 55
1975 90
1976 113
1977 111
1978 89
1979 92
1980 98
1981 121
1982 129
1983 115
1984 148
1985 157
1986 144
1987 148
1988 130
1989 175
1990 207
1991 208
1992 203
1993 224
1994 196
1995 184
1996 215
1997 197
1998 188
1999 222
2000 188
2001 201
2002 207
2003 193
2004 207
2005 254
2006 239
2007 252
2008 243
2009 245
2010 286
2011 310
2012 278
2013 278
2014 306
2015 312
2016 282
2017 244
2018 263
2019 259
2020 274
2021 278
2022 191
2023 179
2024 58

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9,363 results

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Page 1
Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain.
Chuapoco MR, Flytzanis NC, Goeden N, Christopher Octeau J, Roxas KM, Chan KY, Scherrer J, Winchester J, Blackburn RJ, Campos LJ, Man KNM, Sun J, Chen X, Lefevre A, Singh VP, Arokiaraj CM, Shay TF, Vendemiatti J, Jang MJ, Mich JK, Bishaw Y, Gore BB, Omstead V, Taskin N, Weed N, Levi BP, Ting JT, Miller CT, Deverman BE, Pickel J, Tian L, Fox AS, Gradinaru V. Chuapoco MR, et al. Nat Nanotechnol. 2023 Oct;18(10):1241-1251. doi: 10.1038/s41565-023-01419-x. Epub 2023 Jul 10. Nat Nanotechnol. 2023. PMID: 37430038 Free PMC article.
Here we report on AAV.CAP-Mac, an engineered variant identified by screening in adult marmosets and newborn macaques, which has improved delivery efficiency in the brains of multiple non-human primate species: marmoset, rhesus macaque and green monkey. CAP-Mac is ne …
Here we report on AAV.CAP-Mac, an engineered variant identified by screening in adult marmosets and newborn macaques, which has impro …
Airway T cells are a correlate of i.v. Bacille Calmette-Guerin-mediated protection against tuberculosis in rhesus macaques.
Darrah PA, Zeppa JJ, Wang C, Irvine EB, Bucsan AN, Rodgers MA, Pokkali S, Hackney JA, Kamath M, White AG, Borish HJ, Frye LJ, Tomko J, Kracinovsky K, Lin PL, Klein E, Scanga CA, Alter G, Fortune SM, Lauffenburger DA, Flynn JL, Seder RA, Maiello P, Roederer M. Darrah PA, et al. Cell Host Microbe. 2023 Jun 14;31(6):962-977.e8. doi: 10.1016/j.chom.2023.05.006. Epub 2023 Jun 1. Cell Host Microbe. 2023. PMID: 37267955
However, recent work revealed that intravenous (i.v.) BCG administration yielded greater protection in macaques. Here, we perform a dose-ranging study of i.v. BCG vaccination in macaques to generate a range of immune responses and define correlates of protect …
However, recent work revealed that intravenous (i.v.) BCG administration yielded greater protection in macaques. Here, we perform a …
Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques.
Tong D, Zhang M, Yang Y, Xia H, Tong H, Zhang H, Zeng W, Liu M, Wu Y, Ma H, Hu X, Liu W, Cai Y, Yao Y, Yao Y, Liu K, Shan S, Li Y, Gao G, Guo W, Peng Y, Chen S, Rao J, Zhao J, Min J, Zhu Q, Zheng Y, Liu L, Shan C, Zhong K, Qiu Z, Jin T, Chiu S, Yuan Z, Xue T. Tong D, et al. Protein Cell. 2022 Jul 15;14(1):69-73. doi: 10.1093/procel/pwac020. eCollection 2023 Jan. Protein Cell. 2022. PMID: 36726759 Free PMC article. No abstract available.
Long-acting lenacapavir acts as an effective preexposure prophylaxis in a rectal SHIV challenge macaque model.
Bekerman E, Yant SR, VanderVeen L, Hansen D, Lu B, Rowe W, Wang K, Callebaut C. Bekerman E, et al. J Clin Invest. 2023 Aug 15;133(16):e167818. doi: 10.1172/JCI167818. J Clin Invest. 2023. PMID: 37384413 Free PMC article.
Here, we assessed the efficacy of LEN for PrEP using a single high-dose simian-human immunodeficiency virus (SHIV) rectal challenge macaque model. ...A high-dose SHIV inoculum for the PrEP efficacy evaluation was identified via virus titration in untreated …
Here, we assessed the efficacy of LEN for PrEP using a single high-dose simian-human immunodeficiency virus (SHIV) rectal challenge …
Single-dose VSV-based vaccine protects cynomolgus macaques from disease after Tai Forest virus infection.
Fletcher P, O'Donnell KL, Doratt BM, Malherbe DC, Clancy CS, Rhoderick JF, Feldmann F, Hanley PW, Ksiazek TG, Geisbert TW, Messaoudi I, Marzi A. Fletcher P, et al. Emerg Microbes Infect. 2023 Dec;12(2):2239950. doi: 10.1080/22221751.2023.2239950. Emerg Microbes Infect. 2023. PMID: 37470396 Free PMC article.
We developed a vesicular stomatitis virus (VSV)-based vaccine expressing the TAFV glycoprotein as the viral antigen and assessed it for protective efficacy in nonhuman primates (NHPs). Following a single high-dose vaccination, NHPs developed antigen-specific binding and ne …
We developed a vesicular stomatitis virus (VSV)-based vaccine expressing the TAFV glycoprotein as the viral antigen and assessed it for prot …
Infection of the maternal-fetal interface and vertical transmission following low-dose inoculation of pregnant rhesus macaques (Macaca mulatta) with an African-lineage Zika virus.
Koenig MR, Mitzey AM, Morgan TK, Zeng X, Simmons HA, Mejia A, Leyva Jaimes F, Keding LT, Crooks CM, Weiler AM, Bohm EK, Aliota MT, Friedrich TC, Mohr EL, Golos TG. Koenig MR, et al. PLoS One. 2023 May 4;18(5):e0284964. doi: 10.1371/journal.pone.0284964. eCollection 2023. PLoS One. 2023. PMID: 37141276 Free PMC article.
The low inoculating dose used in this study suggests a low minimal infectious dose for rhesus macaques. Vertical transmission with a low dose in macaques further supports the high epidemic potential of African ZIKV strains....
The low inoculating dose used in this study suggests a low minimal infectious dose for rhesus macaques. Vertical transm …
Defining the Cynomolgus Macaque (Macaca fascicularis) Animal Model for Aerosolized Venezuelan Equine Encephalitis: Importance of Challenge Dose and Viral Subtype.
Burke CW, Gardner CL, Goodson AI, Piper AE, Erwin-Cohen RA, White CE, Glass PJ. Burke CW, et al. Viruses. 2023 Nov 29;15(12):2351. doi: 10.3390/v15122351. Viruses. 2023. PMID: 38140592 Free PMC article.
The sporadic outbreaks present a challenge for testing medical countermeasures (MCMs) in humans; therefore, well-defined animal models are needed for FDA Animal Rule licensure. The cynomolgus macaque (CM) model has been studied extensively at high challenge doses of the VE …
The sporadic outbreaks present a challenge for testing medical countermeasures (MCMs) in humans; therefore, well-defined animal models are n …
Accelerated DNA vaccine regimen provides protection against Crimean-Congo hemorrhagic fever virus challenge in a macaque model.
Hawman DW, Meade-White K, Leventhal S, Appelberg S, Ahlén G, Nikouyan N, Clancy C, Smith B, Hanley P, Lovaglio J, Mirazimi A, Sällberg M, Feldmann H. Hawman DW, et al. Mol Ther. 2023 Feb 1;31(2):387-397. doi: 10.1016/j.ymthe.2022.09.016. Epub 2022 Oct 3. Mol Ther. 2023. PMID: 36184852 Free PMC article.
Currently, there are no widely approved vaccines for CCHFV. We have previously reported significant efficacy of a three-dose DNA-based vaccination regimen for CCHFV in cynomolgus macaques (Macaca fasicularis). ...We found that a two-dose vaccination re …
Currently, there are no widely approved vaccines for CCHFV. We have previously reported significant efficacy of a three-dose DNA-base …
Ad26.COV2.S and SARS-CoV-2 spike protein ferritin nanoparticle vaccine protect against SARS-CoV-2 Omicron BA.5 challenge in macaques.
Yu J, Thomas PV, Sciacca M, Wu C, Liu J, He X, Miller J, Hachmann NP, Surve N, McMahan K, Jacob-Dolan C, Powers O, Hall K, Barrett J, Hope D, Mazurek CR, Murdza T, Chang WC, Golub E, Rees PA, Peterson CE, Hajduczki A, Chen WH, Martinez EJ, Hussin E, Lange C, Gong H, Matyas GR, Rao M, Suthar M, Boursiquot M, Cook A, Pessaint L, Lewis MG, Andersen H, Bolton DL, Michael NL, Joyce MG, Modjarrad K, Barouch DH. Yu J, et al. Cell Rep Med. 2023 Apr 18;4(4):101018. doi: 10.1016/j.xcrm.2023.101018. Epub 2023 Mar 27. Cell Rep Med. 2023. PMID: 37023746 Free PMC article.
We report the immunogenicity and protective efficacy of vaccine regimens consisting of the vector-based Ad26.COV2.S vaccine and the adjuvanted spike ferritin nanoparticle (SpFN) vaccine against a high-dose, mismatched Omicron BA.5 challenge in macaques. The SpFNx3 a …
We report the immunogenicity and protective efficacy of vaccine regimens consisting of the vector-based Ad26.COV2.S vaccine and the adjuvant …
Comparative Aspects of Ricin Toxicity by Inhalation.
Stoll A, Shenton DP, Green AC, Holley JL. Stoll A, et al. Toxins (Basel). 2023 Apr 13;15(4):281. doi: 10.3390/toxins15040281. Toxins (Basel). 2023. PMID: 37104219 Free PMC article. Review.
The pathogenesis of ricin toxicity following inhalation has been investigated in many animal models, including the non-human primate (predominantly the rhesus macaque), pig, rabbit and rodent. The toxicity and associated pathology described in animal models are broadly sim …
The pathogenesis of ricin toxicity following inhalation has been investigated in many animal models, including the non-human primate (predom …
9,363 results